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Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

Persson, Bertil R LU ; Baureus Koch, Catrin LU ; Grafström, Gustav LU ; Ceberg, Crister LU ; Munck af Rosenschöld, Per LU ; Widegren, Bengt LU and Salford, Leif LU (2008) 1st International Conference on Biomedical Engineering and Informatics In BMEI 2008: Proceedings International Conference on BioMedical Engineering and Informatics, vol 2 p.243-247
Abstract
Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05)... (More)
Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
BMEI 2008: Proceedings International Conference on BioMedical Engineering and Informatics, vol 2
pages
243 - 247
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
1st International Conference on Biomedical Engineering and Informatics
external identifiers
  • WOS:000257001500048
  • Scopus:51649122272
ISBN
978-0-7695-3118-2
DOI
10.1109/BMEI.2008.345
language
English
LU publication?
yes
id
d7a364b9-4489-4668-973e-83e0ff2e97d8 (old id 1406835)
date added to LUP
2009-06-04 09:47:32
date last changed
2017-01-01 08:07:32
@inproceedings{d7a364b9-4489-4668-973e-83e0ff2e97d8,
  abstract     = {Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p &lt; 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.},
  author       = {Persson, Bertil R and Baureus Koch, Catrin and Grafström, Gustav and Ceberg, Crister and Munck af Rosenschöld, Per and Widegren, Bengt and Salford, Leif},
  booktitle    = {BMEI 2008: Proceedings International Conference on BioMedical Engineering and Informatics, vol 2},
  isbn         = {978-0-7695-3118-2},
  language     = {eng},
  pages        = {243--247},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  title        = {Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells},
  url          = {http://dx.doi.org/10.1109/BMEI.2008.345},
  year         = {2008},
}