Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells
Persson, Bertil R LU
; Baureus Koch, Catrin
LU
; Grafström, Gustav
LU
; Ceberg, Crister
LU
; Munck af Rosenschöld, Per
LU
; Widegren, Bengt
LU
and Salford, Leif
LU
(2008)
1st International Conference on Biomedical Engineering and Informatics
In BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
2.
p.243-247
- Abstract
- Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05)... (More)
- Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1406835
- author
- Persson, Bertil R
LU
; Baureus Koch, Catrin
LU
; Grafström, Gustav
LU
; Ceberg, Crister
LU
; Munck af Rosenschöld, Per
LU
; Widegren, Bengt
LU
and Salford, Leif
LU
- organization
- publishing date
- 2008
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- BioMedical Engineering and Informatics : New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 - New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
- series title
- BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
- volume
- 2
- article number
- 4549171
- pages
- 243 - 247
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- 1st International Conference on Biomedical Engineering and Informatics
- conference location
- Sanya, China
- conference dates
- 2008-05-27 - 2008-05-30
- external identifiers
-
- wos:000257001500048
- scopus:51649122272
- ISBN
- 9780769531182
- DOI
- 10.1109/BMEI.2008.345
- language
- English
- LU publication?
- yes
- id
- d7a364b9-4489-4668-973e-83e0ff2e97d8 (old id 1406835)
- date added to LUP
- 2016-04-04 12:12:37
- date last changed
- 2023-07-20 09:41:20
@inproceedings{d7a364b9-4489-4668-973e-83e0ff2e97d8,
abstract = {{Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.}},
author = {{Persson, Bertil R and Baureus Koch, Catrin and Grafström, Gustav and Ceberg, Crister and Munck af Rosenschöld, Per and Widegren, Bengt and Salford, Leif}},
booktitle = {{BioMedical Engineering and Informatics : New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008}},
isbn = {{9780769531182}},
language = {{eng}},
pages = {{243--247}},
publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
series = {{BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008}},
title = {{Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells}},
url = {{http://dx.doi.org/10.1109/BMEI.2008.345}},
doi = {{10.1109/BMEI.2008.345}},
volume = {{2}},
year = {{2008}},
}