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Integrated system for interstitial photodynamic therapy

Andersson-Engels, Stefan LU ; Bendsöe, Niels LU ; Johansson, Thomas LU ; Pålsson, Sara LU ; Soto Thompson, Marcelo LU ; Stenram, Unne LU ; Svanberg, Katarina LU and Svanberg, Sune LU (2002) Conference on Advanced Optical Devices, Technologies, and Medical Applications 5123. p.293-302
Abstract
To develop PDT beyond treatment of thin superficial tumours, to also be an efficient treatment alternative for deeply located and/or thick tumours, a system based on interstitial illumination using multiple fibres has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumours and tumours in the oral cavity. In interstitial PDT one needs to use multiple fibres for light delivery in order to allow treatments of tumours larger than a few millimetres in diameter. Our system consists of a laser light source, a beam-splitting system dividing the light into three or six output fibres and a custom-made dosimetry programme. The concept is then to use these fibres not only for delivering the... (More)
To develop PDT beyond treatment of thin superficial tumours, to also be an efficient treatment alternative for deeply located and/or thick tumours, a system based on interstitial illumination using multiple fibres has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumours and tumours in the oral cavity. In interstitial PDT one needs to use multiple fibres for light delivery in order to allow treatments of tumours larger than a few millimetres in diameter. Our system consists of a laser light source, a beam-splitting system dividing the light into three or six output fibres and a custom-made dosimetry programme. The concept is then to use these fibres not only for delivering the treatment light but also to measure parameters of interest for the treatment outcome. The fluence rate of the light emitted by each fibre is measured at the positions of the other fibre tips. From these results the light dose at all positions could be recalculated. Changes in optical properties as well as bleaching and concentration of the photosensitizer during the treatment could be monitored and compensated for in the dosimetry. Tumours have been treated both in experimental studies and in patients with thick superficial Basal Cell Carcinomas. Almost all treated skin lesions responded with complete response. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
optical fibre, diode laser, interstitial photodynamic therapy, ALA, light dosimetry, Basal Cell Carcinoma
host publication
Advanced Optical Devices, Technologies, and Medical Applications
volume
5123
pages
293 - 302
publisher
SPIE
conference name
Conference on Advanced Optical Devices, Technologies, and Medical Applications
conference location
Riga, Latvia
conference dates
2002-08-19 - 2002-08-22
external identifiers
  • wos:000185350700042
  • scopus:0344081990
ISSN
0277-786X
1996-756X
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Atomic physics (011013005), Oncology, MV (013035000), Department of Clinical Sciences, Lund (013230000)
id
34775c42-484c-4741-869f-d2c8753cb13a (old id 1407040)
date added to LUP
2016-04-01 11:40:36
date last changed
2021-02-17 02:53:31
@inproceedings{34775c42-484c-4741-869f-d2c8753cb13a,
  abstract     = {To develop PDT beyond treatment of thin superficial tumours, to also be an efficient treatment alternative for deeply located and/or thick tumours, a system based on interstitial illumination using multiple fibres has been developed. Conditions that could benefit from such a treatment modality are for instance malignant brain tumours and tumours in the oral cavity. In interstitial PDT one needs to use multiple fibres for light delivery in order to allow treatments of tumours larger than a few millimetres in diameter. Our system consists of a laser light source, a beam-splitting system dividing the light into three or six output fibres and a custom-made dosimetry programme. The concept is then to use these fibres not only for delivering the treatment light but also to measure parameters of interest for the treatment outcome. The fluence rate of the light emitted by each fibre is measured at the positions of the other fibre tips. From these results the light dose at all positions could be recalculated. Changes in optical properties as well as bleaching and concentration of the photosensitizer during the treatment could be monitored and compensated for in the dosimetry. Tumours have been treated both in experimental studies and in patients with thick superficial Basal Cell Carcinomas. Almost all treated skin lesions responded with complete response.},
  author       = {Andersson-Engels, Stefan and Bendsöe, Niels and Johansson, Thomas and Pålsson, Sara and Soto Thompson, Marcelo and Stenram, Unne and Svanberg, Katarina and Svanberg, Sune},
  booktitle    = {Advanced Optical Devices, Technologies, and Medical Applications},
  issn         = {0277-786X},
  language     = {eng},
  pages        = {293--302},
  publisher    = {SPIE},
  title        = {Integrated system for interstitial photodynamic therapy},
  url          = {https://lup.lub.lu.se/search/ws/files/2590304/2366221.pdf},
  volume       = {5123},
  year         = {2002},
}