Advanced

Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory

Brakebusch, Cord; Seidenbecher, Constanze I.; Asztély, Fredrik LU ; Rauch, Uwe LU ; Matthies, Henry; Meyer, Hannelore; Krug, Manfred; Böckers, Tobias M.; Zhou, Xiaohong LU and Kreutz, Michael R., et al. (2002) In Molecular and Cellular Biology 22(21). p.7417-7427
Abstract
Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has been suggested to play a role in central nervous system fiber tract development. To study the role of brevican in the development and function of the brain, we generated mice lacking a functional brevican gene. These mice are viable and fertile and have a normal life span. Brain anatomy was normal, although alterations in the expression of neurocan were detected. Perineuronal nets formed but appeared to be less prominent in mutant than in wild-type mice. Brevican-deficient mice showed significant deficits in the maintenance of hippocampal... (More)
Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has been suggested to play a role in central nervous system fiber tract development. To study the role of brevican in the development and function of the brain, we generated mice lacking a functional brevican gene. These mice are viable and fertile and have a normal life span. Brain anatomy was normal, although alterations in the expression of neurocan were detected. Perineuronal nets formed but appeared to be less prominent in mutant than in wild-type mice. Brevican-deficient mice showed significant deficits in the maintenance of hippocampal long-term potentiation (LTP). However, no obvious impairment of excitatory and inhibitory synaptic transmission was found, suggesting a complex cause for the LTP defect. Detailed behavioral analysis revealed no statistically significant deficits in learning and memory. These data indicate that brevican is not crucial for brain development but has restricted structural and functional roles. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular and Cellular Biology
volume
22
issue
21
pages
7417 - 7427
publisher
American Society for Microbiology
external identifiers
  • pmid:12370289
  • wos:000178586900006
  • scopus:0036838079
ISSN
0270-7306
DOI
10.1128/MCB.22.21.7417-7427.2002
language
English
LU publication?
yes
id
11c62805-7f8e-441f-9e27-c21cba861c45 (old id 141942)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12370289&query_hl=130
date added to LUP
2007-07-06 09:07:14
date last changed
2017-08-06 03:44:55
@article{11c62805-7f8e-441f-9e27-c21cba861c45,
  abstract     = {Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has been suggested to play a role in central nervous system fiber tract development. To study the role of brevican in the development and function of the brain, we generated mice lacking a functional brevican gene. These mice are viable and fertile and have a normal life span. Brain anatomy was normal, although alterations in the expression of neurocan were detected. Perineuronal nets formed but appeared to be less prominent in mutant than in wild-type mice. Brevican-deficient mice showed significant deficits in the maintenance of hippocampal long-term potentiation (LTP). However, no obvious impairment of excitatory and inhibitory synaptic transmission was found, suggesting a complex cause for the LTP defect. Detailed behavioral analysis revealed no statistically significant deficits in learning and memory. These data indicate that brevican is not crucial for brain development but has restricted structural and functional roles.},
  author       = {Brakebusch, Cord and Seidenbecher, Constanze I. and Asztély, Fredrik and Rauch, Uwe and Matthies, Henry and Meyer, Hannelore and Krug, Manfred and Böckers, Tobias M. and Zhou, Xiaohong and Kreutz, Michael R. and Montag, Dirk and Gundelfinger, Eckart D. and Fässler, Reinhard},
  issn         = {0270-7306},
  language     = {eng},
  number       = {21},
  pages        = {7417--7427},
  publisher    = {American Society for Microbiology},
  series       = {Molecular and Cellular Biology},
  title        = {Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory},
  url          = {http://dx.doi.org/10.1128/MCB.22.21.7417-7427.2002},
  volume       = {22},
  year         = {2002},
}