Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate
(2009) In Journal of Dispersion Science and Technology 30(6). p.920-928- Abstract
- The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1424986
- author
- Lundberg, Dan LU ; Lafitte, Géraldine LU ; Ljusberg, Helena LU ; Lennernaes, Pernilla and Thuresson, Krister LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- self-emulsifying drug-delivery system, mucin, microemulsion, Bioavailability, cationic amphiphile
- in
- Journal of Dispersion Science and Technology
- volume
- 30
- issue
- 6
- pages
- 920 - 928
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000266436200022
- scopus:70449411604
- ISSN
- 0193-2691
- DOI
- 10.1080/01932690802646264
- language
- English
- LU publication?
- yes
- id
- f05469b5-bb4e-4011-afb3-b025ae1bafa2 (old id 1424986)
- date added to LUP
- 2016-04-01 13:53:08
- date last changed
- 2022-04-22 00:10:45
@article{f05469b5-bb4e-4011-afb3-b025ae1bafa2, abstract = {{The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.}}, author = {{Lundberg, Dan and Lafitte, Géraldine and Ljusberg, Helena and Lennernaes, Pernilla and Thuresson, Krister}}, issn = {{0193-2691}}, keywords = {{self-emulsifying drug-delivery system; mucin; microemulsion; Bioavailability; cationic amphiphile}}, language = {{eng}}, number = {{6}}, pages = {{920--928}}, publisher = {{Taylor & Francis}}, series = {{Journal of Dispersion Science and Technology}}, title = {{Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate}}, url = {{http://dx.doi.org/10.1080/01932690802646264}}, doi = {{10.1080/01932690802646264}}, volume = {{30}}, year = {{2009}}, }