Advanced

Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate

Lundberg, Dan LU ; Lafitte, Géraldine LU ; Ljusberg, Helena LU ; Lennernaes, Pernilla and Thuresson, Krister LU (2009) In Journal of Dispersion Science and Technology 30(6). p.920-928
Abstract
The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
self-emulsifying drug-delivery system, mucin, microemulsion, Bioavailability, cationic amphiphile
in
Journal of Dispersion Science and Technology
volume
30
issue
6
pages
920 - 928
publisher
Taylor & Francis
external identifiers
  • wos:000266436200022
  • scopus:70449411604
ISSN
0193-2691
DOI
10.1080/01932690802646264
language
English
LU publication?
yes
id
f05469b5-bb4e-4011-afb3-b025ae1bafa2 (old id 1424986)
date added to LUP
2009-07-02 16:49:41
date last changed
2017-01-01 05:55:59
@article{f05469b5-bb4e-4011-afb3-b025ae1bafa2,
  abstract     = {The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.},
  author       = {Lundberg, Dan and Lafitte, Géraldine and Ljusberg, Helena and Lennernaes, Pernilla and Thuresson, Krister},
  issn         = {0193-2691},
  keyword      = {self-emulsifying drug-delivery system,mucin,microemulsion,Bioavailability,cationic amphiphile},
  language     = {eng},
  number       = {6},
  pages        = {920--928},
  publisher    = {Taylor & Francis},
  series       = {Journal of Dispersion Science and Technology},
  title        = {Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate},
  url          = {http://dx.doi.org/10.1080/01932690802646264},
  volume       = {30},
  year         = {2009},
}