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The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.

Giwercman, Yvonne LU ; Abrahamsson, Per-Anders LU ; Giwercman, Aleksander LU ; Gadaleanu, Virgil and Ahlgren, Göran LU (2005) In European Urology 48(Jul 20). p.679-685
Abstract
Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN < 23 had a higher... (More)
Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN < 23 had a higher risk of dying from the disease than their counterparts with longer repeats. Conclusions: Men with CaP were more often genetically predisposed to a higher enzymatic activity in the turn over from T to DHT compared to the general population. In our population, androgen receptor genotype affected CaP outcome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
5 alpha-reductase, prostate cancer, polymorphism, androgen receptor
in
European Urology
volume
48
issue
Jul 20
pages
679 - 685
publisher
Elsevier
external identifiers
  • pmid:16039774
  • wos:000232257300020
  • scopus:24644440563
ISSN
1873-7560
DOI
10.1016/j.eururo.2005.06.011
language
English
LU publication?
yes
id
149d3dbb-a396-4794-898e-6280fde74a0c (old id 143185)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16039774&dopt=Abstract
date added to LUP
2007-07-20 12:07:37
date last changed
2017-10-01 04:36:19
@article{149d3dbb-a396-4794-898e-6280fde74a0c,
  abstract     = {Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN &lt; 23 had a higher risk of dying from the disease than their counterparts with longer repeats. Conclusions: Men with CaP were more often genetically predisposed to a higher enzymatic activity in the turn over from T to DHT compared to the general population. In our population, androgen receptor genotype affected CaP outcome.},
  author       = {Giwercman, Yvonne and Abrahamsson, Per-Anders and Giwercman, Aleksander and Gadaleanu, Virgil and Ahlgren, Göran},
  issn         = {1873-7560},
  keyword      = {5 alpha-reductase,prostate cancer,polymorphism,androgen receptor},
  language     = {eng},
  number       = {Jul 20},
  pages        = {679--685},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.},
  url          = {http://dx.doi.org/10.1016/j.eururo.2005.06.011},
  volume       = {48},
  year         = {2005},
}