Advanced

Circulating Interferon-gamma and White Matter Brain Damage in Preterm Infants.

Pupp, Ingrid LU ; Harling, Solveig; Berg, Ann-Cathrine LU ; Cilio, Corrado LU ; Hellström-Westas, Lena LU and Ley, David LU (2005) In Pediatric Research 58(5). p.946-952
Abstract
The fetal inflammatory response has been suggested as causal in neonatal morbidity. Serial levels of circulating cytokines were evaluated in 74 infants with a mean gestational age (GA) of 27.1 wk. Pro-inflammatory and modulatory (IL-4, IL-10) cytokines were analyzed from cord blood, and at 6, 24, and 72 h postnatal age. Measure of cytokine burden over time was assessed by calculating the area under curve (AUC) for analyzed levels (0-72 h). Premature rupture of membranes (PROM) was associated with higher levels of IL-2 at birth and at 6 h, of IFN-gamma at 6 and 24 h postnatal age and of TNF-alpha at 6 and 24 h. Levels of IFN-gamma at 6, 24, and 72 It were increased in infants developing white matter brain damage (WMD) compared with those... (More)
The fetal inflammatory response has been suggested as causal in neonatal morbidity. Serial levels of circulating cytokines were evaluated in 74 infants with a mean gestational age (GA) of 27.1 wk. Pro-inflammatory and modulatory (IL-4, IL-10) cytokines were analyzed from cord blood, and at 6, 24, and 72 h postnatal age. Measure of cytokine burden over time was assessed by calculating the area under curve (AUC) for analyzed levels (0-72 h). Premature rupture of membranes (PROM) was associated with higher levels of IL-2 at birth and at 6 h, of IFN-gamma at 6 and 24 h postnatal age and of TNF-alpha at 6 and 24 h. Levels of IFN-gamma at 6, 24, and 72 It were increased in infants developing white matter brain damage (WMD) compared with those without WMD. Infants with arterial hypotension requiring dopamine treatment had an increase in IL-6 with a peak at 6 It of age. Severe intraventricular hemorrhage (IVH) was associated with increase in AUC, whereas WMD was associated with increase in AUC. A fetal immune response with increased postnatal levels of IFN-gamma was associated with development of WMD. PROM was associated with a T-helper I cytokine response with increased levels of IFN-gamma. Type of inflammatory response appears of importance for subsequent morbidity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
58
issue
5
pages
946 - 952
publisher
International Pediatric Foundation Inc.
external identifiers
  • pmid:16183810
  • wos:000232779000022
  • scopus:27144507441
ISSN
1530-0447
DOI
10.1203/01.PDR.0000182592.76702.E8
language
English
LU publication?
yes
id
78129ffa-5c7b-44da-8487-445337f62fff (old id 143437)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16183810&dopt=Abstract
date added to LUP
2007-07-23 10:46:54
date last changed
2017-09-24 03:41:26
@article{78129ffa-5c7b-44da-8487-445337f62fff,
  abstract     = {The fetal inflammatory response has been suggested as causal in neonatal morbidity. Serial levels of circulating cytokines were evaluated in 74 infants with a mean gestational age (GA) of 27.1 wk. Pro-inflammatory and modulatory (IL-4, IL-10) cytokines were analyzed from cord blood, and at 6, 24, and 72 h postnatal age. Measure of cytokine burden over time was assessed by calculating the area under curve (AUC) for analyzed levels (0-72 h). Premature rupture of membranes (PROM) was associated with higher levels of IL-2 at birth and at 6 h, of IFN-gamma at 6 and 24 h postnatal age and of TNF-alpha at 6 and 24 h. Levels of IFN-gamma at 6, 24, and 72 It were increased in infants developing white matter brain damage (WMD) compared with those without WMD. Infants with arterial hypotension requiring dopamine treatment had an increase in IL-6 with a peak at 6 It of age. Severe intraventricular hemorrhage (IVH) was associated with increase in AUC, whereas WMD was associated with increase in AUC. A fetal immune response with increased postnatal levels of IFN-gamma was associated with development of WMD. PROM was associated with a T-helper I cytokine response with increased levels of IFN-gamma. Type of inflammatory response appears of importance for subsequent morbidity.},
  author       = {Pupp, Ingrid and Harling, Solveig and Berg, Ann-Cathrine and Cilio, Corrado and Hellström-Westas, Lena and Ley, David},
  issn         = {1530-0447},
  language     = {eng},
  number       = {5},
  pages        = {946--952},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {Circulating Interferon-gamma and White Matter Brain Damage in Preterm Infants.},
  url          = {http://dx.doi.org/10.1203/01.PDR.0000182592.76702.E8},
  volume       = {58},
  year         = {2005},
}