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Cerebellar inhibition of inferior olivary transmission in the decerebrate ferret.

Svensson, Pär LU ; Bengtsson, Fredrik LU and Hesslow, Germund LU (2006) In Experimental Brain Research 168. p.241-253
Abstract
Stimulation around the superior cerebellar peduncle or within the deep cerebellar nuclei is known to inhibit the inferior olive with a very long latency. It has been suggested that this inhibition is mediated by the GABA-ergic nucleo-olivary pathway, but alternative explanations such as activation of an indirect excitatory pathway or a pathway via the red nucleus are possible. A long-latency inhibition via the nucleo-olivary pathway would have profound implications for cerebellar function and the present study was performed to test alternative explanations and to characterize the nucleo-olivary inhibition. Climbing fibre responses (CFRs), evoked by periorbital stimulation and recorded from the cerebellar cortex, could be inhibited by... (More)
Stimulation around the superior cerebellar peduncle or within the deep cerebellar nuclei is known to inhibit the inferior olive with a very long latency. It has been suggested that this inhibition is mediated by the GABA-ergic nucleo-olivary pathway, but alternative explanations such as activation of an indirect excitatory pathway or a pathway via the red nucleus are possible. A long-latency inhibition via the nucleo-olivary pathway would have profound implications for cerebellar function and the present study was performed to test alternative explanations and to characterize the nucleo-olivary inhibition. Climbing fibre responses (CFRs), evoked by periorbital stimulation and recorded from the cerebellar cortex, could be inhibited by stimulation of two distinct mesencephalic areas. One was located within the superior cerebellar peduncle and the other about 1 mm further ventrally. Inhibition evoked from either area occurred in the inferior olive and was independent of a red nucleus relay. Single Purkinje cell recordings revealed that inhibition from the ventral area was not secondary to olivary activation. It is concluded that stimulation of the ventral area activated nucleo-olivary fibres. The inhibition elicited by stimulation within the peduncle probably resulted from indirect activation on the nucleo-olivary fibres via antidromic activation of the interpositus nucleus. The time courses of the inhibition from the two areas were indistinguishable. The duration of the strongest inhibition was short and had a sharp peak at about 30 ms. It is suggested that the time course of the inhibition is important for temporal regulation of learned responses. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inferior olive, climbing fibre, deep cerebellar nuclei, Purkinje cell, nucleo-olivary, inhibition
in
Experimental Brain Research
volume
168
pages
241 - 253
publisher
Springer
external identifiers
  • pmid:16132968
  • wos:000233822700023
  • scopus:28644450803
  • pmid:16132968
ISSN
0014-4819
DOI
10.1007/s00221-005-0086-y
language
English
LU publication?
yes
id
6f07c982-b9a7-427b-88e1-934d2266b716 (old id 143955)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16132968&dopt=Abstract
date added to LUP
2016-04-01 12:37:44
date last changed
2022-02-11 17:33:34
@article{6f07c982-b9a7-427b-88e1-934d2266b716,
  abstract     = {{Stimulation around the superior cerebellar peduncle or within the deep cerebellar nuclei is known to inhibit the inferior olive with a very long latency. It has been suggested that this inhibition is mediated by the GABA-ergic nucleo-olivary pathway, but alternative explanations such as activation of an indirect excitatory pathway or a pathway via the red nucleus are possible. A long-latency inhibition via the nucleo-olivary pathway would have profound implications for cerebellar function and the present study was performed to test alternative explanations and to characterize the nucleo-olivary inhibition. Climbing fibre responses (CFRs), evoked by periorbital stimulation and recorded from the cerebellar cortex, could be inhibited by stimulation of two distinct mesencephalic areas. One was located within the superior cerebellar peduncle and the other about 1 mm further ventrally. Inhibition evoked from either area occurred in the inferior olive and was independent of a red nucleus relay. Single Purkinje cell recordings revealed that inhibition from the ventral area was not secondary to olivary activation. It is concluded that stimulation of the ventral area activated nucleo-olivary fibres. The inhibition elicited by stimulation within the peduncle probably resulted from indirect activation on the nucleo-olivary fibres via antidromic activation of the interpositus nucleus. The time courses of the inhibition from the two areas were indistinguishable. The duration of the strongest inhibition was short and had a sharp peak at about 30 ms. It is suggested that the time course of the inhibition is important for temporal regulation of learned responses.}},
  author       = {{Svensson, Pär and Bengtsson, Fredrik and Hesslow, Germund}},
  issn         = {{0014-4819}},
  keywords     = {{inferior olive; climbing fibre; deep cerebellar nuclei; Purkinje cell; nucleo-olivary; inhibition}},
  language     = {{eng}},
  pages        = {{241--253}},
  publisher    = {{Springer}},
  series       = {{Experimental Brain Research}},
  title        = {{Cerebellar inhibition of inferior olivary transmission in the decerebrate ferret.}},
  url          = {{http://dx.doi.org/10.1007/s00221-005-0086-y}},
  doi          = {{10.1007/s00221-005-0086-y}},
  volume       = {{168}},
  year         = {{2006}},
}