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Relationship Between Mild Primary Hyperparathyroidism and Left Ventricular Structure and Diastolic Performance

Birgander, Mats; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Willenheimer, Ronnie LU and Rydberg, Erik LU (2009) In The Endocrinologist 19(4). p.187-191
Abstract
Aim: This study aims to investigate cardiac structure and function in patients with asymptomatic primary hyperparathyroidism (pHPT) and if there is any relation to severity regarding serum levels of calcium (Ca) and parathyroid hormone. Methods and Results: We consecutively included 50 patients (mean age 62.9 +/- 11 years, 45 women) with clinically diagnosed pHPT. We prospectively recruited 50 healthy control subjects, matched for age and sex. Standard transthoracic echocardiographic examination was performed using the 4 standard views and structural parameters as well as left ventricular (LV) systolic and diastolic function was determined. Mean LV ejection fraction and atrioventricular plane displacement were on average normal and did not... (More)
Aim: This study aims to investigate cardiac structure and function in patients with asymptomatic primary hyperparathyroidism (pHPT) and if there is any relation to severity regarding serum levels of calcium (Ca) and parathyroid hormone. Methods and Results: We consecutively included 50 patients (mean age 62.9 +/- 11 years, 45 women) with clinically diagnosed pHPT. We prospectively recruited 50 healthy control subjects, matched for age and sex. Standard transthoracic echocardiographic examination was performed using the 4 standard views and structural parameters as well as left ventricular (LV) systolic and diastolic function was determined. Mean LV ejection fraction and atrioventricular plane displacement were on average normal and did not differ between patients and controls. However, pHPT patients had significantly greater LV mass (148 +/- 37 vs. 127 +/- 29 g, P = 0.002), LV end diastolic area (81 +/- 20 vs. 68 +/- 18 cm(2), p = 0.003), LV posterior wall diameter (8.9 +/- 1 vs. 8.1 +/- 1 min, P = 0.006), and LA size (21 +/- 3 vs. 19 +/- 2 mm, P < 0.001). A moderate to severe LV diastolic filling impairment was present in substantially more pHPT patients, compared with control subjects (36% vs. 4%, P < 0:001). Conclusion: Patients with asymptomatic pHPT showed LV structural changes and impaired LV diastolic function. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prognosis, echocardiography, heart failure, primary hyperparathyroidism
in
The Endocrinologist
volume
19
issue
4
pages
187 - 191
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000268054600012
  • scopus:68849101817
ISSN
1539-9192
DOI
10.1097/TEN.0b013e3181abe7a3
language
English
LU publication?
yes
id
e7958958-6394-4826-bb7f-bddb75361ebe (old id 1461712)
date added to LUP
2009-08-31 10:40:29
date last changed
2017-01-01 04:47:42
@article{e7958958-6394-4826-bb7f-bddb75361ebe,
  abstract     = {Aim: This study aims to investigate cardiac structure and function in patients with asymptomatic primary hyperparathyroidism (pHPT) and if there is any relation to severity regarding serum levels of calcium (Ca) and parathyroid hormone. Methods and Results: We consecutively included 50 patients (mean age 62.9 +/- 11 years, 45 women) with clinically diagnosed pHPT. We prospectively recruited 50 healthy control subjects, matched for age and sex. Standard transthoracic echocardiographic examination was performed using the 4 standard views and structural parameters as well as left ventricular (LV) systolic and diastolic function was determined. Mean LV ejection fraction and atrioventricular plane displacement were on average normal and did not differ between patients and controls. However, pHPT patients had significantly greater LV mass (148 +/- 37 vs. 127 +/- 29 g, P = 0.002), LV end diastolic area (81 +/- 20 vs. 68 +/- 18 cm(2), p = 0.003), LV posterior wall diameter (8.9 +/- 1 vs. 8.1 +/- 1 min, P = 0.006), and LA size (21 +/- 3 vs. 19 +/- 2 mm, P &lt; 0.001). A moderate to severe LV diastolic filling impairment was present in substantially more pHPT patients, compared with control subjects (36% vs. 4%, P &lt; 0:001). Conclusion: Patients with asymptomatic pHPT showed LV structural changes and impaired LV diastolic function.},
  author       = {Birgander, Mats and Bondeson, Anne-Greth and Bondeson, Lennart and Willenheimer, Ronnie and Rydberg, Erik},
  issn         = {1539-9192},
  keyword      = {prognosis,echocardiography,heart failure,primary hyperparathyroidism},
  language     = {eng},
  number       = {4},
  pages        = {187--191},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {The Endocrinologist},
  title        = {Relationship Between Mild Primary Hyperparathyroidism and Left Ventricular Structure and Diastolic Performance},
  url          = {http://dx.doi.org/10.1097/TEN.0b013e3181abe7a3},
  volume       = {19},
  year         = {2009},
}