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Uterine Remodeling During Pregnancy - Studies on the Effect of Heparin/Heparan Sulfate

Åkerud, Anna LU (2009) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2009:83.
Abstract
During pregnancy, the uterine tissues must go through a major transformation to be able to first hold the growing fetus and then, at term, expel it through the opened birth canal (cervix). It is a requirement for successful labor that there is adequate cervical softening combined with effective myometrial contractions. This is accomplished by an extensive remodeling of the extracellular matrix in both the cervix and the uterus, executed by different types of cells and mediators in a complex interplay. The overall purpose of this project was to investigate mechanisms controlling the remodeling of the uterus and cervix before parturition.

This thesis demonstrates that fibroblasts with an active pro-inflammatory phenotype are... (More)
During pregnancy, the uterine tissues must go through a major transformation to be able to first hold the growing fetus and then, at term, expel it through the opened birth canal (cervix). It is a requirement for successful labor that there is adequate cervical softening combined with effective myometrial contractions. This is accomplished by an extensive remodeling of the extracellular matrix in both the cervix and the uterus, executed by different types of cells and mediators in a complex interplay. The overall purpose of this project was to investigate mechanisms controlling the remodeling of the uterus and cervix before parturition.

This thesis demonstrates that fibroblasts with an active pro-inflammatory phenotype are important for the transformation of the uterine cervix preceding labor. Moreover, heparan sulfate proteoglycans appear to be central for the remodeling of the cervix and uterus before parturition, as shown by the finding that heparin fragments can be used in a clinical setting to prevent protracted labor. (Less)
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author
supervisor
opponent
  • Spillmann, Dorothe, Department of Medical Biochemistry and Microbiology, Uppsala University
organization
publishing date
type
Thesis
publication status
published
subject
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2009:83
pages
120 pages
publisher
Department of Experimental Medical Science, Lund Univeristy
defense location
Segerfalkssalen
defense date
2009-09-24 09:00
ISSN
1652-8220
ISBN
978-91-86253-71-4
language
English
LU publication?
yes
id
59756f06-8d32-465a-a3b1-4c893ade4307 (old id 1466514)
date added to LUP
2009-08-28 11:57:41
date last changed
2016-09-19 08:44:49
@phdthesis{59756f06-8d32-465a-a3b1-4c893ade4307,
  abstract     = {During pregnancy, the uterine tissues must go through a major transformation to be able to first hold the growing fetus and then, at term, expel it through the opened birth canal (cervix). It is a requirement for successful labor that there is adequate cervical softening combined with effective myometrial contractions. This is accomplished by an extensive remodeling of the extracellular matrix in both the cervix and the uterus, executed by different types of cells and mediators in a complex interplay. The overall purpose of this project was to investigate mechanisms controlling the remodeling of the uterus and cervix before parturition. <br/><br>
This thesis demonstrates that fibroblasts with an active pro-inflammatory phenotype are important for the transformation of the uterine cervix preceding labor. Moreover, heparan sulfate proteoglycans appear to be central for the remodeling of the cervix and uterus before parturition, as shown by the finding that heparin fragments can be used in a clinical setting to prevent protracted labor.},
  author       = {Åkerud, Anna},
  isbn         = {978-91-86253-71-4},
  issn         = {1652-8220},
  language     = {eng},
  pages        = {120},
  publisher    = {Department of Experimental Medical Science, Lund Univeristy},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Uterine Remodeling During Pregnancy - Studies on the Effect of Heparin/Heparan Sulfate},
  volume       = {2009:83},
  year         = {2009},
}