Absolute quantification of cerebral blood flow: correlation between dynamic susceptibility contrast MRI and model-free arterial spin labeling.
Knutsson, Linda LU
; van Westen, Danielle
LU
; Petersen, Esben T
; Markenroth Bloch, Karin
LU
; Holtås, Stig
LU
; Ståhlberg, Freddy
LU
and Wirestam, Ronnie
LU
(2010)
In Magnetic Resonance Imaging
28(1).
p.1-7
- Abstract
- PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous... (More)
- PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous output function time integral obtained from the sagittal sinus. RESULTS: In GM, the average DSC-MRI CBF estimate was 150+/-45 ml/(min 100 g) (mean+/-SD) while the corresponding ASL CBF was 44+/-10 ml/(min 100 g). The linear correlation between GM CBF estimates obtained by DSC-MRI and ASL was r=.89, and observed DSC-to-ASL CBF ratios differed by less than 3% between GM and tumor regions. CONCLUSIONS: A satisfactory positive linear correlation between the CBF estimates obtained by model-free ASL and DSC-MRI was observed, and DSC-to-ASL CBF ratios showed no obvious tissue dependence. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1469537
- author
- Knutsson, Linda
LU
; van Westen, Danielle
LU
; Petersen, Esben T
; Markenroth Bloch, Karin
LU
; Holtås, Stig
LU
; Ståhlberg, Freddy
LU
and Wirestam, Ronnie
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Magnetic Resonance Imaging
- volume
- 28
- issue
- 1
- pages
- 1 - 7
- publisher
- Elsevier
- external identifiers
-
- wos:000276648600001
- pmid:19695822
- scopus:71049115166
- pmid:19695822
- ISSN
- 1873-5894
- DOI
- 10.1016/j.mri.2009.06.006
- project
- MRI brain perfusion quantification at 3 tesla using arterial spin labeling
- Optimisation and Validation of Dynamic Susceptibility Contrast MRI
- language
- English
- LU publication?
- yes
- id
- 7fb8a699-97cb-4671-be72-cc0aa32ca088 (old id 1469537)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19695822?dopt=Abstract
- date added to LUP
- 2016-04-04 08:32:19
- date last changed
- 2022-05-16 21:24:19
@article{7fb8a699-97cb-4671-be72-cc0aa32ca088,
abstract = {{PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous output function time integral obtained from the sagittal sinus. RESULTS: In GM, the average DSC-MRI CBF estimate was 150+/-45 ml/(min 100 g) (mean+/-SD) while the corresponding ASL CBF was 44+/-10 ml/(min 100 g). The linear correlation between GM CBF estimates obtained by DSC-MRI and ASL was r=.89, and observed DSC-to-ASL CBF ratios differed by less than 3% between GM and tumor regions. CONCLUSIONS: A satisfactory positive linear correlation between the CBF estimates obtained by model-free ASL and DSC-MRI was observed, and DSC-to-ASL CBF ratios showed no obvious tissue dependence.}},
author = {{Knutsson, Linda and van Westen, Danielle and Petersen, Esben T and Markenroth Bloch, Karin and Holtås, Stig and Ståhlberg, Freddy and Wirestam, Ronnie}},
issn = {{1873-5894}},
language = {{eng}},
number = {{1}},
pages = {{1--7}},
publisher = {{Elsevier}},
series = {{Magnetic Resonance Imaging}},
title = {{Absolute quantification of cerebral blood flow: correlation between dynamic susceptibility contrast MRI and model-free arterial spin labeling.}},
url = {{http://dx.doi.org/10.1016/j.mri.2009.06.006}},
doi = {{10.1016/j.mri.2009.06.006}},
volume = {{28}},
year = {{2010}},
}