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Absolute quantification of cerebral blood flow: correlation between dynamic susceptibility contrast MRI and model-free arterial spin labeling.

Knutsson, Linda LU ; van Westen, Danielle LU ; Petersen, Esben T; Markenroth Bloch, Karin LU ; Holtås, Stig LU ; Ståhlberg, Freddy LU and Wirestam, Ronnie LU (2010) In Magnetic Resonance Imaging 28(1). p.1-7
Abstract
PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous... (More)
PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous output function time integral obtained from the sagittal sinus. RESULTS: In GM, the average DSC-MRI CBF estimate was 150+/-45 ml/(min 100 g) (mean+/-SD) while the corresponding ASL CBF was 44+/-10 ml/(min 100 g). The linear correlation between GM CBF estimates obtained by DSC-MRI and ASL was r=.89, and observed DSC-to-ASL CBF ratios differed by less than 3% between GM and tumor regions. CONCLUSIONS: A satisfactory positive linear correlation between the CBF estimates obtained by model-free ASL and DSC-MRI was observed, and DSC-to-ASL CBF ratios showed no obvious tissue dependence. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance Imaging
volume
28
issue
1
pages
1 - 7
publisher
Elsevier
external identifiers
  • wos:000276648600001
  • pmid:19695822
  • scopus:71049115166
ISSN
1873-5894
DOI
10.1016/j.mri.2009.06.006
language
English
LU publication?
yes
id
7fb8a699-97cb-4671-be72-cc0aa32ca088 (old id 1469537)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19695822?dopt=Abstract
date added to LUP
2009-09-03 15:23:15
date last changed
2018-06-10 04:49:42
@article{7fb8a699-97cb-4671-be72-cc0aa32ca088,
  abstract     = {PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous output function time integral obtained from the sagittal sinus. RESULTS: In GM, the average DSC-MRI CBF estimate was 150+/-45 ml/(min 100 g) (mean+/-SD) while the corresponding ASL CBF was 44+/-10 ml/(min 100 g). The linear correlation between GM CBF estimates obtained by DSC-MRI and ASL was r=.89, and observed DSC-to-ASL CBF ratios differed by less than 3% between GM and tumor regions. CONCLUSIONS: A satisfactory positive linear correlation between the CBF estimates obtained by model-free ASL and DSC-MRI was observed, and DSC-to-ASL CBF ratios showed no obvious tissue dependence.},
  author       = {Knutsson, Linda and van Westen, Danielle and Petersen, Esben T and Markenroth Bloch, Karin and Holtås, Stig and Ståhlberg, Freddy and Wirestam, Ronnie},
  issn         = {1873-5894},
  language     = {eng},
  number       = {1},
  pages        = {1--7},
  publisher    = {Elsevier},
  series       = {Magnetic Resonance Imaging},
  title        = {Absolute quantification of cerebral blood flow: correlation between dynamic susceptibility contrast MRI and model-free arterial spin labeling.},
  url          = {http://dx.doi.org/10.1016/j.mri.2009.06.006},
  volume       = {28},
  year         = {2010},
}