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Chapter 28 future perspective in peripheral nerve reconstruction.

Dahlin, Lars LU ; Johansson, Fredrik LU ; Lindwall, Charlotta LU and Kanje, Martin LU (2009) In International Review of Neurobiology 87. p.507-530
Abstract
Nerve injuries induce severe disability and suffering for patients. Profound alterations in nerve trunks, neurons, and the central nervous system are induced rapidly after injury. This includes activation of intracellular signal transduction mechanisms aiming at the transfer of the cells into a regenerative state through the induction of the appropriate gene programs. The understanding of the neurobiological mechanisms that occur after injury can be used to design modern strategies for reconstruction after nerve injuries. Signal transduction mechanisms for instance may be targets for pharmacological intervention to stimulate nerve regeneration. Nerve injuries, particularly where there is a defect between the severed nerve trunks like in... (More)
Nerve injuries induce severe disability and suffering for patients. Profound alterations in nerve trunks, neurons, and the central nervous system are induced rapidly after injury. This includes activation of intracellular signal transduction mechanisms aiming at the transfer of the cells into a regenerative state through the induction of the appropriate gene programs. The understanding of the neurobiological mechanisms that occur after injury can be used to design modern strategies for reconstruction after nerve injuries. Signal transduction mechanisms for instance may be targets for pharmacological intervention to stimulate nerve regeneration. Nerve injuries, particularly where there is a defect between the severed nerve trunks like in brachial plexus lesions, remain a challenge for the surgeon. Reconstruction of nerve injuries with a defect requires utilization of graft material, which can be of various designs. Application of autologous nerve grafts and use of nerve transfers are the most common clinical solutions to overcome problems with nerve defects. In this chapter we discuss the future perspective of nerve reconstruction with focus on signal transduction mechanisms and new avenues to bridge nerve defects using nanomodified graft surfaces. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Review of Neurobiology
volume
87
pages
507 - 530
publisher
Elsevier
external identifiers
  • WOS:000269657600028
  • Scopus:70349787495
ISSN
0074-7742
DOI
10.1016/S0074-7742(09)87028-1
language
English
LU publication?
yes
id
db167681-270e-486d-9f7b-2768806a2fca (old id 1469697)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19682657?dopt=Abstract
date added to LUP
2009-09-03 13:47:34
date last changed
2017-01-01 07:51:59
@article{db167681-270e-486d-9f7b-2768806a2fca,
  abstract     = {Nerve injuries induce severe disability and suffering for patients. Profound alterations in nerve trunks, neurons, and the central nervous system are induced rapidly after injury. This includes activation of intracellular signal transduction mechanisms aiming at the transfer of the cells into a regenerative state through the induction of the appropriate gene programs. The understanding of the neurobiological mechanisms that occur after injury can be used to design modern strategies for reconstruction after nerve injuries. Signal transduction mechanisms for instance may be targets for pharmacological intervention to stimulate nerve regeneration. Nerve injuries, particularly where there is a defect between the severed nerve trunks like in brachial plexus lesions, remain a challenge for the surgeon. Reconstruction of nerve injuries with a defect requires utilization of graft material, which can be of various designs. Application of autologous nerve grafts and use of nerve transfers are the most common clinical solutions to overcome problems with nerve defects. In this chapter we discuss the future perspective of nerve reconstruction with focus on signal transduction mechanisms and new avenues to bridge nerve defects using nanomodified graft surfaces.},
  author       = {Dahlin, Lars and Johansson, Fredrik and Lindwall, Charlotta and Kanje, Martin},
  issn         = {0074-7742},
  language     = {eng},
  pages        = {507--530},
  publisher    = {Elsevier},
  series       = {International Review of Neurobiology},
  title        = {Chapter 28 future perspective in peripheral nerve reconstruction.},
  url          = {http://dx.doi.org/10.1016/S0074-7742(09)87028-1},
  volume       = {87},
  year         = {2009},
}