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Noninvasive monitoring of brain temperature during mild hypothermia

Weis, Jan ; Covaciu, Lucian ; Rubertsson, Sten ; Allers, Mats ; Lunderquist, Anders LU and Ahlstrom, Hakan (2009) In Magnetic Resonance Imaging 27(7). p.923-932
Abstract
The main purpose of this study was to verify the feasibility of brain temperature mapping with high-spatial- and reduced-spectral-resolution magnetic resonance spectroscopic imaging (MRSI). A secondary goal was to determine the temperature coefficient of water chemical shift in the brain with and without internal spectral reference. The accuracy of the proposed MRSI method was verified using a water and vegetable oil phantom. Selective decrease of the brain temperature of pigs was induced by intranasal cooling. Temperature reductions between 2 degrees C and 4 degrees C were achieved within 20 min. The relative changes in temperature during the cooling process were monitored using MRSI. The reference temperature was measured with... (More)
The main purpose of this study was to verify the feasibility of brain temperature mapping with high-spatial- and reduced-spectral-resolution magnetic resonance spectroscopic imaging (MRSI). A secondary goal was to determine the temperature coefficient of water chemical shift in the brain with and without internal spectral reference. The accuracy of the proposed MRSI method was verified using a water and vegetable oil phantom. Selective decrease of the brain temperature of pigs was induced by intranasal cooling. Temperature reductions between 2 degrees C and 4 degrees C were achieved within 20 min. The relative changes in temperature during the cooling process were monitored using MRSI. The reference temperature was measured with MR-compatible fiber-optic probes. Single-voxel H-1 MRS was used for measurement of absolute brain temperature at baseline and at the end of cooling. The temperature coefficient of the water chemical shift of brain tissue measured by MRSI without internal reference was -0.0192 +/- 0.0019 ppm/degrees C. The temperature coefficients of the water chemical shift relative to N-acetylaspartate, choline-containing compounds and creatine were -0.0096 +/- 0.0009, -0.0083 +/- 0.0007 and -0.0091 +/- 0.0011 ppm/degrees C, respectively. The results of this study indicate that MRSI with high spatial and reduced spectral resolutions is a reliable tool for monitoring long-term temperature changes in the brain. (C) 2009 Elsevier Inc. All rights reserved. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Temperature mapping, Selective brain cooling, Hypothermia, Spectroscopy, Spectroscopic imaging
in
Magnetic Resonance Imaging
volume
27
issue
7
pages
923 - 932
publisher
Elsevier
external identifiers
  • wos:000269613000005
  • scopus:68349141237
ISSN
1873-5894
DOI
10.1016/j.mri.2009.01.011
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)
id
eba26eec-ba2c-4d08-8143-18ff20a4e12d (old id 1475072)
date added to LUP
2016-04-01 12:21:57
date last changed
2021-09-01 02:04:31
@article{eba26eec-ba2c-4d08-8143-18ff20a4e12d,
  abstract     = {The main purpose of this study was to verify the feasibility of brain temperature mapping with high-spatial- and reduced-spectral-resolution magnetic resonance spectroscopic imaging (MRSI). A secondary goal was to determine the temperature coefficient of water chemical shift in the brain with and without internal spectral reference. The accuracy of the proposed MRSI method was verified using a water and vegetable oil phantom. Selective decrease of the brain temperature of pigs was induced by intranasal cooling. Temperature reductions between 2 degrees C and 4 degrees C were achieved within 20 min. The relative changes in temperature during the cooling process were monitored using MRSI. The reference temperature was measured with MR-compatible fiber-optic probes. Single-voxel H-1 MRS was used for measurement of absolute brain temperature at baseline and at the end of cooling. The temperature coefficient of the water chemical shift of brain tissue measured by MRSI without internal reference was -0.0192 +/- 0.0019 ppm/degrees C. The temperature coefficients of the water chemical shift relative to N-acetylaspartate, choline-containing compounds and creatine were -0.0096 +/- 0.0009, -0.0083 +/- 0.0007 and -0.0091 +/- 0.0011 ppm/degrees C, respectively. The results of this study indicate that MRSI with high spatial and reduced spectral resolutions is a reliable tool for monitoring long-term temperature changes in the brain. (C) 2009 Elsevier Inc. All rights reserved.},
  author       = {Weis, Jan and Covaciu, Lucian and Rubertsson, Sten and Allers, Mats and Lunderquist, Anders and Ahlstrom, Hakan},
  issn         = {1873-5894},
  language     = {eng},
  number       = {7},
  pages        = {923--932},
  publisher    = {Elsevier},
  series       = {Magnetic Resonance Imaging},
  title        = {Noninvasive monitoring of brain temperature during mild hypothermia},
  url          = {http://dx.doi.org/10.1016/j.mri.2009.01.011},
  doi          = {10.1016/j.mri.2009.01.011},
  volume       = {27},
  year         = {2009},
}