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Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling

Koch, Philipp; Kokaia, Zaal LU ; Lindvall, Olle LU and Bruestle, Oliver (2009) In Lancet Neurology 8(9). p.819-829
Abstract
The increasing availability of human pluripotent stem cells provides new prospects for neural-replacement strategies and disease-related basic research. With almost unlimited potential for self-renewal, the use of human embryonic stem cells (ESCs) bypasses the restricted supply and expandability of primary cells that has been a major bottleneck in previous neural transplantation approaches. Translation of developmental patterning and cell-type specification techniques to human ESC cultures enables in vitro generation of various neuronal and glial cell types. The derivation of stably proliferating neural stem cells from human ESCs further facilitates standardisation and circumvents the problem of batch-to-batch variations commonly... (More)
The increasing availability of human pluripotent stem cells provides new prospects for neural-replacement strategies and disease-related basic research. With almost unlimited potential for self-renewal, the use of human embryonic stem cells (ESCs) bypasses the restricted supply and expandability of primary cells that has been a major bottleneck in previous neural transplantation approaches. Translation of developmental patterning and cell-type specification techniques to human ESC cultures enables in vitro generation of various neuronal and glial cell types. The derivation of stably proliferating neural stem cells from human ESCs further facilitates standardisation and circumvents the problem of batch-to-batch variations commonly encountered in "run-through" protocols, which promote terminal differentiation of pluripotent stem cells into somatic cell types without defined intermediate precursor stages. The advent of cell reprogramming offers an opportunity to translate these advances to induced pluripotent stem cells, thereby enabling the generation of neurons and glia from individual patients. Eventually, reprogramming could provide a supply of autologous neural cells for transplantation, and could lead to the establishment of cellular model systems of neurological diseases. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Lancet Neurology
volume
8
issue
9
pages
819 - 829
publisher
Lancet Ltd
external identifiers
  • wos:000269241700010
  • scopus:68249090535
ISSN
1474-4465
language
English
LU publication?
yes
id
f368ab70-949c-4be1-afe6-c522695f4f10 (old id 1476199)
date added to LUP
2009-09-29 13:03:08
date last changed
2017-08-27 04:06:34
@article{f368ab70-949c-4be1-afe6-c522695f4f10,
  abstract     = {The increasing availability of human pluripotent stem cells provides new prospects for neural-replacement strategies and disease-related basic research. With almost unlimited potential for self-renewal, the use of human embryonic stem cells (ESCs) bypasses the restricted supply and expandability of primary cells that has been a major bottleneck in previous neural transplantation approaches. Translation of developmental patterning and cell-type specification techniques to human ESC cultures enables in vitro generation of various neuronal and glial cell types. The derivation of stably proliferating neural stem cells from human ESCs further facilitates standardisation and circumvents the problem of batch-to-batch variations commonly encountered in "run-through" protocols, which promote terminal differentiation of pluripotent stem cells into somatic cell types without defined intermediate precursor stages. The advent of cell reprogramming offers an opportunity to translate these advances to induced pluripotent stem cells, thereby enabling the generation of neurons and glia from individual patients. Eventually, reprogramming could provide a supply of autologous neural cells for transplantation, and could lead to the establishment of cellular model systems of neurological diseases.},
  author       = {Koch, Philipp and Kokaia, Zaal and Lindvall, Olle and Bruestle, Oliver},
  issn         = {1474-4465},
  language     = {eng},
  number       = {9},
  pages        = {819--829},
  publisher    = {Lancet Ltd},
  series       = {Lancet Neurology},
  title        = {Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling},
  volume       = {8},
  year         = {2009},
}