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Concentrations of Metals, beta-Amyloid and Tau-Markers in Cerebrospinal Fluid in Patients with Alzheimer's Disease

Gerhardsson, Lars; Blennow, Kaj; Lundh, Thomas LU ; Londos, Elisabet LU and Minthon, Lennart LU (2009) In Dementia and Geriatric Cognitive Disorders 28(1). p.88-94
Abstract
Background/Aims: In this study, metal concentrations were related to the levels of well-known Alzheimer markers in cerebrospinal fluid (CSF), such as amyloid-beta (A beta), total tau (T-tau) and phosphorylated-tau (P-tau). Methods: Concentrations of 19 metals (Mg, Ca, V, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg and Pb by inductively coupled plasma-mass spectrometry) and the levels of A beta, T-tau and P-tau in CSF were determined (xMAP technology) in 264 patients with Alzheimer's disease ( AD), and in 54 healthy referents. Results: The AD subjects showed positive correlations between CSF-T-tau and CSF-P-tau versus CSF-Mn (r(s) = 0.22, p = 0.004; r(s) = 0.18, p = 0.021). CSF-T-tau, however, showed a negative correlation... (More)
Background/Aims: In this study, metal concentrations were related to the levels of well-known Alzheimer markers in cerebrospinal fluid (CSF), such as amyloid-beta (A beta), total tau (T-tau) and phosphorylated-tau (P-tau). Methods: Concentrations of 19 metals (Mg, Ca, V, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg and Pb by inductively coupled plasma-mass spectrometry) and the levels of A beta, T-tau and P-tau in CSF were determined (xMAP technology) in 264 patients with Alzheimer's disease ( AD), and in 54 healthy referents. Results: The AD subjects showed positive correlations between CSF-T-tau and CSF-P-tau versus CSF-Mn (r(s) = 0.22, p = 0.004; r(s) = 0.18, p = 0.021). CSF-T-tau, however, showed a negative correlation with CSF-Cs (r(s) = -0.17; p = 0.027). In subjects with severe AD, CSF-A beta showed a strong positive correlation with CSF-Cs (r(s) = 0.49; p = 0.026), while CSF-T-tau showed a strong negative correlation with CSF-Cs (r(s) = -0.49; p = 0.026). Also, CSF P-tau was negatively associated with CSF-Cs (r(s) = -0.41; p = 0.06). Conclusion: The different relationships between the CSF-levels of A beta and tau-markers versus the levels of CSF-Mn and CSF-Cs may be due to different binding affinity between these metals and metal binding proteins in the CSF and the surrounding brain. Copyright (c) 2009 S. Karger AG, Basel (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Tau-markers, beta-Amyloid, Metals, Alzheimer's disease, Cerebrospinal fluid
in
Dementia and Geriatric Cognitive Disorders
volume
28
issue
1
pages
88 - 94
publisher
Karger
external identifiers
  • wos:000269132700013
  • scopus:68349091417
ISSN
1420-8008
DOI
10.1159/000233353
language
English
LU publication?
yes
id
415934ac-f950-4d5b-83c2-f3491106c8d6 (old id 1477051)
date added to LUP
2009-09-23 15:47:15
date last changed
2017-05-28 03:30:18
@article{415934ac-f950-4d5b-83c2-f3491106c8d6,
  abstract     = {Background/Aims: In this study, metal concentrations were related to the levels of well-known Alzheimer markers in cerebrospinal fluid (CSF), such as amyloid-beta (A beta), total tau (T-tau) and phosphorylated-tau (P-tau). Methods: Concentrations of 19 metals (Mg, Ca, V, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg and Pb by inductively coupled plasma-mass spectrometry) and the levels of A beta, T-tau and P-tau in CSF were determined (xMAP technology) in 264 patients with Alzheimer's disease ( AD), and in 54 healthy referents. Results: The AD subjects showed positive correlations between CSF-T-tau and CSF-P-tau versus CSF-Mn (r(s) = 0.22, p = 0.004; r(s) = 0.18, p = 0.021). CSF-T-tau, however, showed a negative correlation with CSF-Cs (r(s) = -0.17; p = 0.027). In subjects with severe AD, CSF-A beta showed a strong positive correlation with CSF-Cs (r(s) = 0.49; p = 0.026), while CSF-T-tau showed a strong negative correlation with CSF-Cs (r(s) = -0.49; p = 0.026). Also, CSF P-tau was negatively associated with CSF-Cs (r(s) = -0.41; p = 0.06). Conclusion: The different relationships between the CSF-levels of A beta and tau-markers versus the levels of CSF-Mn and CSF-Cs may be due to different binding affinity between these metals and metal binding proteins in the CSF and the surrounding brain. Copyright (c) 2009 S. Karger AG, Basel},
  author       = {Gerhardsson, Lars and Blennow, Kaj and Lundh, Thomas and Londos, Elisabet and Minthon, Lennart},
  issn         = {1420-8008},
  keyword      = {Tau-markers,beta-Amyloid,Metals,Alzheimer's disease,Cerebrospinal fluid},
  language     = {eng},
  number       = {1},
  pages        = {88--94},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Concentrations of Metals, beta-Amyloid and Tau-Markers in Cerebrospinal Fluid in Patients with Alzheimer's Disease},
  url          = {http://dx.doi.org/10.1159/000233353},
  volume       = {28},
  year         = {2009},
}