Erectile dysfunction in healthy subjects predicts reduced coronary flow velocity reserve.
Borgquist, Rasmus LU
; Gudmundsson, Petri
; Winter, Reidar
LU
; Nilsson, Peter
LU
and Willenheimer, Ronnie
LU
(2006)
In International Journal of Cardiology
112(2).
p.166-170
- Abstract
- Background: Erectile dysfunction is associated with, and may be the first sign of coronary artery disease. We aimed to assess whether men with erectile dysfunction but without cardiovascular disease have reduced coronary flow reserve, as a sign of early coronary atherosclerosis. Methods: We investigated 12 men aged 68-73 years with erectile dysfunction, and 12 age-matched controls. Erectile function was evaluated using the validated IIEF-5 questionnaire. A score <= 18 (of 25) was defined as erectile dysfunction and >= 21 was considered non-nal. Patients with neurological or psychological reasons for erectile dysfunction were excluded, as were patients with symptoms of or prescribed medication for cardiovascular disease, hypertension... (More)
- Background: Erectile dysfunction is associated with, and may be the first sign of coronary artery disease. We aimed to assess whether men with erectile dysfunction but without cardiovascular disease have reduced coronary flow reserve, as a sign of early coronary atherosclerosis. Methods: We investigated 12 men aged 68-73 years with erectile dysfunction, and 12 age-matched controls. Erectile function was evaluated using the validated IIEF-5 questionnaire. A score <= 18 (of 25) was defined as erectile dysfunction and >= 21 was considered non-nal. Patients with neurological or psychological reasons for erectile dysfunction were excluded, as were patients with symptoms of or prescribed medication for cardiovascular disease, hypertension or diabetes. Coronary flow velocity reserve was measured non-invasively by Doppler in the left anterior descending artery, before and during adenosine infusion. Results: Coronary flow velocity reserve was significantly reduced in subjects with erectile dysfunction: 2.36 versus 3.19; P=0.024. In logistic regression analysis, compared to control subjects, men with erectile dysfunction had significantly increased risk of reduced coronary flow velocity reserve (<= 3.0): odds ratio 15.4, P = 0.02. In multivariate analysis, adjusting for age, tobacco use, systolic blood pressure, heart rate and body mass index, erectile dysfunction was the only significant predictor of reduced coronary flow velocity reserve, P=0.016. Conclusions: Men with erectile dysfunction but without diabetes or clinical cardiovascular disease have early signs of coronary artery disease. Our findings suggest that a cardiac risk evaluation may be indicated in men with suspected vasculogenic erectile dysfunction, and these individuals should be considered for primary prevention measures regarding cardiovascular disease risk factors. (c) 2005 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/148141
- author
- Borgquist, Rasmus
LU
; Gudmundsson, Petri
; Winter, Reidar
LU
; Nilsson, Peter
LU
and Willenheimer, Ronnie
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- coronary, ischemic heart disease, echocardiography, microcirculation, risk factors
- in
- International Journal of Cardiology
- volume
- 112
- issue
- 2
- pages
- 166 - 170
- publisher
- Elsevier
- external identifiers
-
- wos:000241275600005
- pmid:16271777
- scopus:33748448621
- ISSN
- 0167-5273
- DOI
- 10.1016/j.ijcard.2005.08.035
- language
- English
- LU publication?
- yes
- id
- bba932c3-a032-4ee0-84e8-dc6d55f003af (old id 148141)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16271777&dopt=Abstract
- date added to LUP
- 2016-04-01 11:38:02
- date last changed
- 2022-01-26 07:54:20
@article{bba932c3-a032-4ee0-84e8-dc6d55f003af,
abstract = {{Background: Erectile dysfunction is associated with, and may be the first sign of coronary artery disease. We aimed to assess whether men with erectile dysfunction but without cardiovascular disease have reduced coronary flow reserve, as a sign of early coronary atherosclerosis. Methods: We investigated 12 men aged 68-73 years with erectile dysfunction, and 12 age-matched controls. Erectile function was evaluated using the validated IIEF-5 questionnaire. A score <= 18 (of 25) was defined as erectile dysfunction and >= 21 was considered non-nal. Patients with neurological or psychological reasons for erectile dysfunction were excluded, as were patients with symptoms of or prescribed medication for cardiovascular disease, hypertension or diabetes. Coronary flow velocity reserve was measured non-invasively by Doppler in the left anterior descending artery, before and during adenosine infusion. Results: Coronary flow velocity reserve was significantly reduced in subjects with erectile dysfunction: 2.36 versus 3.19; P=0.024. In logistic regression analysis, compared to control subjects, men with erectile dysfunction had significantly increased risk of reduced coronary flow velocity reserve (<= 3.0): odds ratio 15.4, P = 0.02. In multivariate analysis, adjusting for age, tobacco use, systolic blood pressure, heart rate and body mass index, erectile dysfunction was the only significant predictor of reduced coronary flow velocity reserve, P=0.016. Conclusions: Men with erectile dysfunction but without diabetes or clinical cardiovascular disease have early signs of coronary artery disease. Our findings suggest that a cardiac risk evaluation may be indicated in men with suspected vasculogenic erectile dysfunction, and these individuals should be considered for primary prevention measures regarding cardiovascular disease risk factors. (c) 2005 Elsevier Ireland Ltd. All rights reserved.}},
author = {{Borgquist, Rasmus and Gudmundsson, Petri and Winter, Reidar and Nilsson, Peter and Willenheimer, Ronnie}},
issn = {{0167-5273}},
keywords = {{coronary; ischemic heart disease; echocardiography; microcirculation; risk factors}},
language = {{eng}},
number = {{2}},
pages = {{166--170}},
publisher = {{Elsevier}},
series = {{International Journal of Cardiology}},
title = {{Erectile dysfunction in healthy subjects predicts reduced coronary flow velocity reserve.}},
url = {{https://lup.lub.lu.se/search/files/2570839/625167.pdf}},
doi = {{10.1016/j.ijcard.2005.08.035}},
volume = {{112}},
year = {{2006}},
}