Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging.
Heiberg, Einar LU ; Engblom, Henrik LU ; Engvall, Jan ; Hedström, Erik LU
; Ugander, Martin
LU
and Arheden, Håkan
LU
(2005)
In Scandinavian Cardiovascular Journal
39(5).
p.267-275
- Abstract
- Objective. Accurate and reproducible assessment of myocardial infarction is important for treatment planning in patients with ischemic heart disease. This study describes a novel method to quantify myocardial infarction by semi-automatic delineation of hyperenhanced myocardium in delayed contrast enhanced (DE) magnetic resonance (MR) images. Design. The proposed method automatically detects the hyperenhanced tissue by first determining the signal intensity of non-enhanced myocardium. A fast level set algorithm was used to limit the heterogeneity of the hyperenhanced regions, and to exclude small regions that constitute noise rather than infarction. The method was evaluated in 40 patients; 20 with acute infarction and 20 with chronic healed... (More)
- Objective. Accurate and reproducible assessment of myocardial infarction is important for treatment planning in patients with ischemic heart disease. This study describes a novel method to quantify myocardial infarction by semi-automatic delineation of hyperenhanced myocardium in delayed contrast enhanced (DE) magnetic resonance (MR) images. Design. The proposed method automatically detects the hyperenhanced tissue by first determining the signal intensity of non-enhanced myocardium. A fast level set algorithm was used to limit the heterogeneity of the hyperenhanced regions, and to exclude small regions that constitute noise rather than infarction. The method was evaluated in 40 patients; 20 with acute infarction and 20 with chronic healed infarction using scanners from two different manufacturers. Infarct size measured by the proposed semi-automatic method was compared with manual measurements from three experienced observers. The software used is freely available for research purposes at http://segment.heiberg.se. Results. The difference in infarct size between semi-automatic quantification and the mean of the three observers was 6.1±6.6 ml (mean±SD), and the interobserver variability (SD) was 4.2 ml. Conclusions. The method presented is a highly automated method for analyzing myocardial viability from DE-MR images. The bias of the method is acceptable and the variability is in the same order of magnitude as the interobserver variability for manual delineations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/148154
- author
- Heiberg, Einar
LU
; Engblom, Henrik
LU
; Engvall, Jan
; Hedström, Erik
LU
; Ugander, Martin
LU
and Arheden, Håkan
LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- MRI, myocardial infarction, quantification, viability
- in
- Scandinavian Cardiovascular Journal
- volume
- 39
- issue
- 5
- pages
- 267 - 275
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:16269396
- wos:000233674900003
- scopus:32144435734
- ISSN
- 1651-2006
- DOI
- 10.1080/14017430500340543
- language
- English
- LU publication?
- yes
- id
- 26fcd802-ce2a-4c9b-aeba-48b3967711b4 (old id 148154)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16269396&dopt=Abstract
- date added to LUP
- 2016-04-01 16:43:55
- date last changed
- 2023-01-05 01:50:27
@article{26fcd802-ce2a-4c9b-aeba-48b3967711b4,
abstract = {{Objective. Accurate and reproducible assessment of myocardial infarction is important for treatment planning in patients with ischemic heart disease. This study describes a novel method to quantify myocardial infarction by semi-automatic delineation of hyperenhanced myocardium in delayed contrast enhanced (DE) magnetic resonance (MR) images. Design. The proposed method automatically detects the hyperenhanced tissue by first determining the signal intensity of non-enhanced myocardium. A fast level set algorithm was used to limit the heterogeneity of the hyperenhanced regions, and to exclude small regions that constitute noise rather than infarction. The method was evaluated in 40 patients; 20 with acute infarction and 20 with chronic healed infarction using scanners from two different manufacturers. Infarct size measured by the proposed semi-automatic method was compared with manual measurements from three experienced observers. The software used is freely available for research purposes at http://segment.heiberg.se. Results. The difference in infarct size between semi-automatic quantification and the mean of the three observers was 6.1±6.6 ml (mean±SD), and the interobserver variability (SD) was 4.2 ml. Conclusions. The method presented is a highly automated method for analyzing myocardial viability from DE-MR images. The bias of the method is acceptable and the variability is in the same order of magnitude as the interobserver variability for manual delineations.}},
author = {{Heiberg, Einar and Engblom, Henrik and Engvall, Jan and Hedström, Erik and Ugander, Martin and Arheden, Håkan}},
issn = {{1651-2006}},
keywords = {{MRI; myocardial infarction; quantification; viability}},
language = {{eng}},
number = {{5}},
pages = {{267--275}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Cardiovascular Journal}},
title = {{Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging.}},
url = {{http://dx.doi.org/10.1080/14017430500340543}},
doi = {{10.1080/14017430500340543}},
volume = {{39}},
year = {{2005}},
}