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Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging.

Heiberg, Einar LU ; Engblom, Henrik LU ; Engvall, Jan; Hedström, Erik LU ; Ugander, Martin LU and Arheden, Håkan LU (2005) In Scandinavian Cardiovascular Journal 39(5). p.267-275
Abstract
Objective. Accurate and reproducible assessment of myocardial infarction is important for treatment planning in patients with ischemic heart disease. This study describes a novel method to quantify myocardial infarction by semi-automatic delineation of hyperenhanced myocardium in delayed contrast enhanced (DE) magnetic resonance (MR) images. Design. The proposed method automatically detects the hyperenhanced tissue by first determining the signal intensity of non-enhanced myocardium. A fast level set algorithm was used to limit the heterogeneity of the hyperenhanced regions, and to exclude small regions that constitute noise rather than infarction. The method was evaluated in 40 patients; 20 with acute infarction and 20 with chronic healed... (More)
Objective. Accurate and reproducible assessment of myocardial infarction is important for treatment planning in patients with ischemic heart disease. This study describes a novel method to quantify myocardial infarction by semi-automatic delineation of hyperenhanced myocardium in delayed contrast enhanced (DE) magnetic resonance (MR) images. Design. The proposed method automatically detects the hyperenhanced tissue by first determining the signal intensity of non-enhanced myocardium. A fast level set algorithm was used to limit the heterogeneity of the hyperenhanced regions, and to exclude small regions that constitute noise rather than infarction. The method was evaluated in 40 patients; 20 with acute infarction and 20 with chronic healed infarction using scanners from two different manufacturers. Infarct size measured by the proposed semi-automatic method was compared with manual measurements from three experienced observers. The software used is freely available for research purposes at http://segment.heiberg.se. Results. The difference in infarct size between semi-automatic quantification and the mean of the three observers was 6.1±6.6 ml (mean±SD), and the interobserver variability (SD) was 4.2 ml. Conclusions. The method presented is a highly automated method for analyzing myocardial viability from DE-MR images. The bias of the method is acceptable and the variability is in the same order of magnitude as the interobserver variability for manual delineations. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MRI, myocardial infarction, quantification, viability
in
Scandinavian Cardiovascular Journal
volume
39
issue
5
pages
267 - 275
publisher
Taylor & Francis
external identifiers
  • pmid:16269396
  • wos:000233674900003
  • scopus:32144435734
ISSN
1651-2006
DOI
10.1080/14017430500340543
language
English
LU publication?
yes
id
26fcd802-ce2a-4c9b-aeba-48b3967711b4 (old id 148154)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16269396&dopt=Abstract
date added to LUP
2007-07-23 10:53:48
date last changed
2017-10-22 04:44:30
@article{26fcd802-ce2a-4c9b-aeba-48b3967711b4,
  abstract     = {Objective. Accurate and reproducible assessment of myocardial infarction is important for treatment planning in patients with ischemic heart disease. This study describes a novel method to quantify myocardial infarction by semi-automatic delineation of hyperenhanced myocardium in delayed contrast enhanced (DE) magnetic resonance (MR) images. Design. The proposed method automatically detects the hyperenhanced tissue by first determining the signal intensity of non-enhanced myocardium. A fast level set algorithm was used to limit the heterogeneity of the hyperenhanced regions, and to exclude small regions that constitute noise rather than infarction. The method was evaluated in 40 patients; 20 with acute infarction and 20 with chronic healed infarction using scanners from two different manufacturers. Infarct size measured by the proposed semi-automatic method was compared with manual measurements from three experienced observers. The software used is freely available for research purposes at http://segment.heiberg.se. Results. The difference in infarct size between semi-automatic quantification and the mean of the three observers was 6.1±6.6 ml (mean±SD), and the interobserver variability (SD) was 4.2 ml. Conclusions. The method presented is a highly automated method for analyzing myocardial viability from DE-MR images. The bias of the method is acceptable and the variability is in the same order of magnitude as the interobserver variability for manual delineations.},
  author       = {Heiberg, Einar and Engblom, Henrik and Engvall, Jan and Hedström, Erik and Ugander, Martin and Arheden, Håkan},
  issn         = {1651-2006},
  keyword      = {MRI,myocardial infarction,quantification,viability},
  language     = {eng},
  number       = {5},
  pages        = {267--275},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {Semi-automatic quantification of myocardial infarction from delayed contrast enhanced magnetic resonance imaging.},
  url          = {http://dx.doi.org/10.1080/14017430500340543},
  volume       = {39},
  year         = {2005},
}