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Motilin concentrations in relation to gastro intestinal dysmotility in diabetes mellitus.

Pendleton, Hillevi LU ; Ekman, Rolf; Olsson, Rolf LU ; Ekberg, Olle LU and Ohlsson, Bodil LU (2009) In European Journal of Internal Medicine 20(6). p.654-659
Abstract
AIM: Dysmotility in the upper gastro intestinal (GI) tract are common problems in diabetics. Many peptides are involved in the regulation of the motility. The aim of this study was to examine whether plasma levels of motilin were related to dysfunction in the oesophagus and stomach in a well-defined diabetic patient group. METHODS: Nineteen patients with symptoms from the GI tract who had been examined with oesophageal manometry, gastric emptying scintigraphy and deep-breathing test were included. They received a fat-rich meal, after which blood samples were collected and analysed for motilin concentrations. RESULTS: Symptoms of abdominal fullness and gastro oesophageal reflux significantly associated with delayed gastric emptying, whereas... (More)
AIM: Dysmotility in the upper gastro intestinal (GI) tract are common problems in diabetics. Many peptides are involved in the regulation of the motility. The aim of this study was to examine whether plasma levels of motilin were related to dysfunction in the oesophagus and stomach in a well-defined diabetic patient group. METHODS: Nineteen patients with symptoms from the GI tract who had been examined with oesophageal manometry, gastric emptying scintigraphy and deep-breathing test were included. They received a fat-rich meal, after which blood samples were collected and analysed for motilin concentrations. RESULTS: Symptoms of abdominal fullness and gastro oesophageal reflux significantly associated with delayed gastric emptying, whereas no symptom correlated to oesophageal dysmotility. Plasma levels of motilin were increased after the fat-rich meal (p=0.000), with no difference between the groups. Abnormal manometry was characterized by aperistalsis and/or simultaneous contractions. The percentage of simultaneous contractions correlated to basic and peak motilin values (r(s)=0.898, p=0.006 and r(s)=0.842, p=0.017, respectively). Gastric emptying did not influence motilin concentrations. CONCLUSION: Plasma motilin concentrations vary with abnormalities of oesophageal motility in diabetics, but not with abnormalities of gastric emptying. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Internal Medicine
volume
20
issue
6
pages
654 - 659
publisher
Elsevier
external identifiers
  • wos:000271359100021
  • pmid:19782932
  • scopus:70349299842
ISSN
1879-0828
DOI
10.1016/j.ejim.2009.05.015
language
English
LU publication?
yes
id
9c0e54f6-b40a-4de9-80c1-aa94bab1330b (old id 1483153)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19782932?dopt=Abstract
date added to LUP
2012-01-18 13:54:08
date last changed
2017-01-01 04:28:58
@article{9c0e54f6-b40a-4de9-80c1-aa94bab1330b,
  abstract     = {AIM: Dysmotility in the upper gastro intestinal (GI) tract are common problems in diabetics. Many peptides are involved in the regulation of the motility. The aim of this study was to examine whether plasma levels of motilin were related to dysfunction in the oesophagus and stomach in a well-defined diabetic patient group. METHODS: Nineteen patients with symptoms from the GI tract who had been examined with oesophageal manometry, gastric emptying scintigraphy and deep-breathing test were included. They received a fat-rich meal, after which blood samples were collected and analysed for motilin concentrations. RESULTS: Symptoms of abdominal fullness and gastro oesophageal reflux significantly associated with delayed gastric emptying, whereas no symptom correlated to oesophageal dysmotility. Plasma levels of motilin were increased after the fat-rich meal (p=0.000), with no difference between the groups. Abnormal manometry was characterized by aperistalsis and/or simultaneous contractions. The percentage of simultaneous contractions correlated to basic and peak motilin values (r(s)=0.898, p=0.006 and r(s)=0.842, p=0.017, respectively). Gastric emptying did not influence motilin concentrations. CONCLUSION: Plasma motilin concentrations vary with abnormalities of oesophageal motility in diabetics, but not with abnormalities of gastric emptying.},
  author       = {Pendleton, Hillevi and Ekman, Rolf and Olsson, Rolf and Ekberg, Olle and Ohlsson, Bodil},
  issn         = {1879-0828},
  language     = {eng},
  number       = {6},
  pages        = {654--659},
  publisher    = {Elsevier},
  series       = {European Journal of Internal Medicine},
  title        = {Motilin concentrations in relation to gastro intestinal dysmotility in diabetes mellitus.},
  url          = {http://dx.doi.org/10.1016/j.ejim.2009.05.015},
  volume       = {20},
  year         = {2009},
}