The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.

Giwercman, Yvonne; Abrahamsson, Per-Anders; Giwercman, Aleksander; Gadaleanu, Virgil; Ahlgren, Göran

The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.

Mark

Giwercman, Yvonne ^LU ; Abrahamsson, Per-Anders ^LU ; Giwercman, Aleksander ^LU ; Gadaleanu, Virgil and Ahlgren, Göran ^LU (2005) In European Urology 48(Jul 20). p.679-685

Abstract: Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN < 23 had a higher... (More); Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN < 23 had a higher risk of dying from the disease than their counterparts with longer repeats. Conclusions: Men with CaP were more often genetically predisposed to a higher enzymatic activity in the turn over from T to DHT compared to the general population. In our population, androgen receptor genotype affected CaP outcome. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/143185

author

Giwercman, Yvonne ^LU ; Abrahamsson, Per-Anders ^LU ; Giwercman, Aleksander ^LU ; Gadaleanu, Virgil and Ahlgren, Göran ^LU

organization

publishing date

2005

type

Contribution to journal

publication status

published

subject

Urology and Nephrology

keywords

5 alpha-reductase, prostate cancer, polymorphism, androgen receptor

in

European Urology

volume

48

issue

Jul 20

pages

679 - 685

publisher

Elsevier

external identifiers

pmid:16039774
wos:000232257300020
scopus:24644440563

ISSN

1873-7560

DOI

10.1016/j.eururo.2005.06.011

language

English

LU publication?

yes

additional info

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Obstetrics and Gynaecology (013242700), Division of urological research (013243410), Molecular Reproductive Medicine (013241710), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Department of Translational Medicine (013017500)

id

149d3dbb-a396-4794-898e-6280fde74a0c (old id 143185)

alternative location

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16039774&dopt=Abstract

date added to LUP

2016-04-01 15:39:41

date last changed

2022-02-12 17:00:50

@article{149d3dbb-a396-4794-898e-6280fde74a0c,
  abstract     = {{Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN &lt; 23 had a higher risk of dying from the disease than their counterparts with longer repeats. Conclusions: Men with CaP were more often genetically predisposed to a higher enzymatic activity in the turn over from T to DHT compared to the general population. In our population, androgen receptor genotype affected CaP outcome.}},
  author       = {{Giwercman, Yvonne and Abrahamsson, Per-Anders and Giwercman, Aleksander and Gadaleanu, Virgil and Ahlgren, Göran}},
  issn         = {{1873-7560}},
  keywords     = {{5 alpha-reductase; prostate cancer; polymorphism; androgen receptor}},
  language     = {{eng}},
  number       = {{Jul 20}},
  pages        = {{679--685}},
  publisher    = {{Elsevier}},
  series       = {{European Urology}},
  title        = {{The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.}},
  url          = {{https://lup.lub.lu.se/search/files/4443473/624938.pdf}},
  doi          = {{10.1016/j.eururo.2005.06.011}},
  volume       = {{48}},
  year         = {{2005}},
}

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The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.