Ectopic Ependymal Cells in Striatum Accompany Neurogenesis in a Rat Model of Stroke.
Danilov, Alexandre LU ; Kokaia, Zaal LU
and Lindvall, Olle
LU
(2012)
In Neuroscience
214.
p.159-170
- Abstract
- Stroke-induced neurogenesis originates from a neural stem cell (NSC) niche in subventricular zone (SVZ). In mice, NSCs are concentrated in a so-called "neurogenic spot" in the lateral angle area of SVZ. We aimed to identify the "neurogenic spot" in the rat SVZ and to characterize the cellular changes in the ependymal cell compartment in this area at different time points after middle cerebral artery occlusion. The majority of ependymal cells outlining the ventricular wall did not proliferate, and their numbers in the "neurogenic spot" declined at six and sixteen weeks after stroke. Cells with the ultrastructural properties of ependymal cells were detected in the adjacent striatum. The number of these ectopic ependymal cells correlated... (More)
- Stroke-induced neurogenesis originates from a neural stem cell (NSC) niche in subventricular zone (SVZ). In mice, NSCs are concentrated in a so-called "neurogenic spot" in the lateral angle area of SVZ. We aimed to identify the "neurogenic spot" in the rat SVZ and to characterize the cellular changes in the ependymal cell compartment in this area at different time points after middle cerebral artery occlusion. The majority of ependymal cells outlining the ventricular wall did not proliferate, and their numbers in the "neurogenic spot" declined at six and sixteen weeks after stroke. Cells with the ultrastructural properties of ependymal cells were detected in the adjacent striatum. The number of these ectopic ependymal cells correlated positively with the magnitude of lateral ventriclar enlargement and negatively with the ependymal cell number in the "neurogenic spot". Ectopic ependymal cells were found along blood vessels, accumulated in the pericyst regions, and participated in scar formation but did not incorporate BrdU. We provide the first evidence for the occurrence of ectopic ependymal cells in the ischemic striatum following stroke. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2519065
- author
- Danilov, Alexandre
LU
; Kokaia, Zaal
LU
and Lindvall, Olle
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuroscience
- volume
- 214
- pages
- 159 - 170
- publisher
- Elsevier
- external identifiers
-
- wos:000305547500014
- pmid:22531371
- scopus:84861830466
- ISSN
- 1873-7544
- DOI
- 10.1016/j.neuroscience.2012.03.062
- language
- English
- LU publication?
- yes
- id
- 14ff5ae7-64f5-4c8e-82ec-ea90e3bdc180 (old id 2519065)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22531371?dopt=Abstract
- date added to LUP
- 2016-04-04 08:04:44
- date last changed
- 2022-02-20 21:13:08
@article{14ff5ae7-64f5-4c8e-82ec-ea90e3bdc180,
abstract = {{Stroke-induced neurogenesis originates from a neural stem cell (NSC) niche in subventricular zone (SVZ). In mice, NSCs are concentrated in a so-called "neurogenic spot" in the lateral angle area of SVZ. We aimed to identify the "neurogenic spot" in the rat SVZ and to characterize the cellular changes in the ependymal cell compartment in this area at different time points after middle cerebral artery occlusion. The majority of ependymal cells outlining the ventricular wall did not proliferate, and their numbers in the "neurogenic spot" declined at six and sixteen weeks after stroke. Cells with the ultrastructural properties of ependymal cells were detected in the adjacent striatum. The number of these ectopic ependymal cells correlated positively with the magnitude of lateral ventriclar enlargement and negatively with the ependymal cell number in the "neurogenic spot". Ectopic ependymal cells were found along blood vessels, accumulated in the pericyst regions, and participated in scar formation but did not incorporate BrdU. We provide the first evidence for the occurrence of ectopic ependymal cells in the ischemic striatum following stroke.}},
author = {{Danilov, Alexandre and Kokaia, Zaal and Lindvall, Olle}},
issn = {{1873-7544}},
language = {{eng}},
pages = {{159--170}},
publisher = {{Elsevier}},
series = {{Neuroscience}},
title = {{Ectopic Ependymal Cells in Striatum Accompany Neurogenesis in a Rat Model of Stroke.}},
url = {{http://dx.doi.org/10.1016/j.neuroscience.2012.03.062}},
doi = {{10.1016/j.neuroscience.2012.03.062}},
volume = {{214}},
year = {{2012}},
}