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Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack.

Eriksson Linsmeier, Cecilia LU ; Prinz, Christelle LU ; Pettersson, Lina LU ; Caroff, Philippe LU ; Samuelson, Lars LU ; Schouenborg, Jens LU ; Montelius, Lars LU and Danielsen, Nils LU (2009) In Nano Letters 9(12). p.4184-4190
Abstract
We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nano Letters
volume
9
issue
12
pages
4184 - 4190
publisher
The American Chemical Society
external identifiers
  • wos:000272395400039
  • pmid:19845389
  • scopus:71949096139
ISSN
1530-6992
DOI
10.1021/nl902413x
language
English
LU publication?
yes
id
193b7c91-23e3-4253-8c90-04c3dfdc49e8 (old id 1500121)
date added to LUP
2009-11-04 12:45:29
date last changed
2017-01-01 06:07:38
@article{193b7c91-23e3-4253-8c90-04c3dfdc49e8,
  abstract     = {We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.},
  author       = {Eriksson Linsmeier, Cecilia and Prinz, Christelle and Pettersson, Lina and Caroff, Philippe and Samuelson, Lars and Schouenborg, Jens and Montelius, Lars and Danielsen, Nils},
  issn         = {1530-6992},
  language     = {eng},
  number       = {12},
  pages        = {4184--4190},
  publisher    = {The American Chemical Society},
  series       = {Nano Letters},
  title        = {Nanowire Biocompatibility in the Brain - Looking for a Needle in a 3D Stack.},
  url          = {http://dx.doi.org/10.1021/nl902413x},
  volume       = {9},
  year         = {2009},
}