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Cerebrospinal Fluid Total Tau Is Associated with Shorter Survival in Dementia with Lewy Bodies.

Boström, Fredrik LU ; Hansson, Oskar LU ; Blennow, Kaj; Gerhardsson, Lars LU ; Lundh, Thomas LU ; Minthon, Lennart LU ; Zetterberg, Henrik and Londos, Elisabet LU (2009) In Dementia and Geriatric Cognitive Disorders 28(4). p.314-319
Abstract
A pathology typical of dementia with Lewy bodies (DLB) has been demonstrated to increase mortality to a greater extent than the pathology of Alzheimer's disease (AD). However, mortality in DLB has also been shown to increase with concomitant AD pathology. Furthermore, in a recent publication, we showed that there is a robust and specific increase in CSF calcium and magnesium in DLB patients compared to both AD patients and controls. Thus, in order to explore the influence of CSF AD markers and trace element concentrations on mortality in DLB, we undertook a longitudinal prospective study of 47 clinically diagnosed DLB patients and 157 AD patients as well as 49 healthy volunteers. Both AD and DLB patients showed an increased mortality... (More)
A pathology typical of dementia with Lewy bodies (DLB) has been demonstrated to increase mortality to a greater extent than the pathology of Alzheimer's disease (AD). However, mortality in DLB has also been shown to increase with concomitant AD pathology. Furthermore, in a recent publication, we showed that there is a robust and specific increase in CSF calcium and magnesium in DLB patients compared to both AD patients and controls. Thus, in order to explore the influence of CSF AD markers and trace element concentrations on mortality in DLB, we undertook a longitudinal prospective study of 47 clinically diagnosed DLB patients and 157 AD patients as well as 49 healthy volunteers. Both AD and DLB patients showed an increased mortality compared to the healthy controls (relative risk: 10 and 8, respectively; p < 0.001). Increased levels of CSF total tau were associated with increased mortality among the DLB patients (p < 0.05), but not among the AD patients or controls. Gender, age, MMSE score, Abeta42 concentration and phosphorylated tau, and CSF trace element concentrations did not influence survival in the obtained models. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
28
issue
4
pages
314 - 319
publisher
Karger
external identifiers
  • wos:000271534800006
  • pmid:19844105
  • scopus:70350059779
ISSN
1420-8008
DOI
10.1159/000249145
language
English
LU publication?
yes
id
50d4088a-1aeb-409e-a43f-29941b3a12c6 (old id 1500160)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19844105?dopt=Abstract
date added to LUP
2009-11-03 12:48:54
date last changed
2017-08-20 04:35:19
@article{50d4088a-1aeb-409e-a43f-29941b3a12c6,
  abstract     = {A pathology typical of dementia with Lewy bodies (DLB) has been demonstrated to increase mortality to a greater extent than the pathology of Alzheimer's disease (AD). However, mortality in DLB has also been shown to increase with concomitant AD pathology. Furthermore, in a recent publication, we showed that there is a robust and specific increase in CSF calcium and magnesium in DLB patients compared to both AD patients and controls. Thus, in order to explore the influence of CSF AD markers and trace element concentrations on mortality in DLB, we undertook a longitudinal prospective study of 47 clinically diagnosed DLB patients and 157 AD patients as well as 49 healthy volunteers. Both AD and DLB patients showed an increased mortality compared to the healthy controls (relative risk: 10 and 8, respectively; p &lt; 0.001). Increased levels of CSF total tau were associated with increased mortality among the DLB patients (p &lt; 0.05), but not among the AD patients or controls. Gender, age, MMSE score, Abeta42 concentration and phosphorylated tau, and CSF trace element concentrations did not influence survival in the obtained models.},
  author       = {Boström, Fredrik and Hansson, Oskar and Blennow, Kaj and Gerhardsson, Lars and Lundh, Thomas and Minthon, Lennart and Zetterberg, Henrik and Londos, Elisabet},
  issn         = {1420-8008},
  language     = {eng},
  number       = {4},
  pages        = {314--319},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Cerebrospinal Fluid Total Tau Is Associated with Shorter Survival in Dementia with Lewy Bodies.},
  url          = {http://dx.doi.org/10.1159/000249145},
  volume       = {28},
  year         = {2009},
}