Toxicity and Dose Response of Intra-Abdominally Administered Poly-L-alpha-Lysine and Poly-L-Glutamate for Postoperative Adhesion Protection.
(2010) In European Surgical Research 44(1). p.17-22- Abstract
- Background/Aims: Two differently charged polypeptides, poly-L-lysine (PL) and poly-L-glutamate (PG), have previously been shown to reduce postoperative intra-abdominal adhesions. This study aims to investigate the possible toxic effects and to establish a lowest effective antiadhesive dose. Methods: 152 mice were investigated with a well-known adhesion model and given different concentrations of the two differently charged polypeptides as well as only the cationic PL. Results: For the first time, a probable toxic level of PL given intraperitoneally (40 mg/kg) and the lowest significant concentration of PL and PG for antiadhesive purposes (1.6 mg/kg) could be established. Conclusion: The gap between the possible toxicity level of PL and the... (More)
- Background/Aims: Two differently charged polypeptides, poly-L-lysine (PL) and poly-L-glutamate (PG), have previously been shown to reduce postoperative intra-abdominal adhesions. This study aims to investigate the possible toxic effects and to establish a lowest effective antiadhesive dose. Methods: 152 mice were investigated with a well-known adhesion model and given different concentrations of the two differently charged polypeptides as well as only the cationic PL. Results: For the first time, a probable toxic level of PL given intraperitoneally (40 mg/kg) and the lowest significant concentration of PL and PG for antiadhesive purposes (1.6 mg/kg) could be established. Conclusion: The gap between the possible toxicity level of PL and the lowest efficient antiadhesive dose is probably too narrow, and the shape and charge of PL warrant continuous research for another polycation in the concept of differently charged polypeptides used as antiadhesive agents. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511776
- author
- Isaksson, Karolin LU ; Åkerberg, Daniel LU ; Andersson, Roland LU and Tingstedt, Bobby LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Surgical Research
- volume
- 44
- issue
- 1
- pages
- 17 - 22
- publisher
- Karger
- external identifiers
-
- wos:000272599800003
- pmid:19923842
- scopus:70449623640
- pmid:19923842
- ISSN
- 0014-312X
- DOI
- 10.1159/000258654
- language
- English
- LU publication?
- yes
- id
- 6bf189aa-3d47-44c0-b37f-b272f9f80a85 (old id 1511776)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19923842?dopt=Abstract
- date added to LUP
- 2016-04-04 07:48:06
- date last changed
- 2022-01-29 02:38:10
@article{6bf189aa-3d47-44c0-b37f-b272f9f80a85, abstract = {{Background/Aims: Two differently charged polypeptides, poly-L-lysine (PL) and poly-L-glutamate (PG), have previously been shown to reduce postoperative intra-abdominal adhesions. This study aims to investigate the possible toxic effects and to establish a lowest effective antiadhesive dose. Methods: 152 mice were investigated with a well-known adhesion model and given different concentrations of the two differently charged polypeptides as well as only the cationic PL. Results: For the first time, a probable toxic level of PL given intraperitoneally (40 mg/kg) and the lowest significant concentration of PL and PG for antiadhesive purposes (1.6 mg/kg) could be established. Conclusion: The gap between the possible toxicity level of PL and the lowest efficient antiadhesive dose is probably too narrow, and the shape and charge of PL warrant continuous research for another polycation in the concept of differently charged polypeptides used as antiadhesive agents.}}, author = {{Isaksson, Karolin and Åkerberg, Daniel and Andersson, Roland and Tingstedt, Bobby}}, issn = {{0014-312X}}, language = {{eng}}, number = {{1}}, pages = {{17--22}}, publisher = {{Karger}}, series = {{European Surgical Research}}, title = {{Toxicity and Dose Response of Intra-Abdominally Administered Poly-L-alpha-Lysine and Poly-L-Glutamate for Postoperative Adhesion Protection.}}, url = {{https://lup.lub.lu.se/search/files/5152324/1515481.pdf}}, doi = {{10.1159/000258654}}, volume = {{44}}, year = {{2010}}, }