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Autoimmune kidney diseases.

Segelmark, Mårten LU and Hellmark, Thomas LU (2010) In Autoimmunity Reviews 9. p.366-371
Abstract
The second most common cause of chronic renal failure is glomerulonephritis, which is a collective term used for numerous diseases with the common denominator of histological renal inflammation emanating from the glomerular tuft. Whether all forms of glomerulonephritis should be considered as autoimmune disease is debatable, but immune mechanisms are important in all of them. This review focuses on four relatively well delineated forms of primary glomerulonephritis: Goodpastures or anti-GBM disease, IgA nephritis, membranous nephropathy and membranoproliferative glomerulonephritis. The autoantibodies are directed either to molecules within the glomeruli, such as the glomerular basement membrane in anti-GBM disease and to the podocytes in... (More)
The second most common cause of chronic renal failure is glomerulonephritis, which is a collective term used for numerous diseases with the common denominator of histological renal inflammation emanating from the glomerular tuft. Whether all forms of glomerulonephritis should be considered as autoimmune disease is debatable, but immune mechanisms are important in all of them. This review focuses on four relatively well delineated forms of primary glomerulonephritis: Goodpastures or anti-GBM disease, IgA nephritis, membranous nephropathy and membranoproliferative glomerulonephritis. The autoantibodies are directed either to molecules within the glomeruli, such as the glomerular basement membrane in anti-GBM disease and to the podocytes in membranous glomerulonephritis, or to components of the immune system such as C3 convertase in membranoproliferative glomerulonephritis and IgA in IgA nephritis. Differences in diagnostic practices and classification controversies obscure comparative epidemiological studies, but there seem to be huge differences between incidence rates between countries and over time, both genetic factors and infections seem to matter but strong indications for a role of other environmental factors are still lacking. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Autoimmunity Reviews
volume
9
pages
366 - 371
publisher
Elsevier
external identifiers
  • wos:000276470100019
  • pmid:19906361
  • scopus:77649231744
ISSN
1873-0183
DOI
10.1016/j.autrev.2009.11.007
language
English
LU publication?
yes
id
199bdd1c-ed0a-4d76-a05e-ebea16ec20d8 (old id 1512032)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19906361?dopt=Abstract
date added to LUP
2009-12-01 14:00:24
date last changed
2018-06-10 04:47:23
@article{199bdd1c-ed0a-4d76-a05e-ebea16ec20d8,
  abstract     = {The second most common cause of chronic renal failure is glomerulonephritis, which is a collective term used for numerous diseases with the common denominator of histological renal inflammation emanating from the glomerular tuft. Whether all forms of glomerulonephritis should be considered as autoimmune disease is debatable, but immune mechanisms are important in all of them. This review focuses on four relatively well delineated forms of primary glomerulonephritis: Goodpastures or anti-GBM disease, IgA nephritis, membranous nephropathy and membranoproliferative glomerulonephritis. The autoantibodies are directed either to molecules within the glomeruli, such as the glomerular basement membrane in anti-GBM disease and to the podocytes in membranous glomerulonephritis, or to components of the immune system such as C3 convertase in membranoproliferative glomerulonephritis and IgA in IgA nephritis. Differences in diagnostic practices and classification controversies obscure comparative epidemiological studies, but there seem to be huge differences between incidence rates between countries and over time, both genetic factors and infections seem to matter but strong indications for a role of other environmental factors are still lacking.},
  author       = {Segelmark, Mårten and Hellmark, Thomas},
  issn         = {1873-0183},
  language     = {eng},
  pages        = {366--371},
  publisher    = {Elsevier},
  series       = {Autoimmunity Reviews},
  title        = {Autoimmune kidney diseases.},
  url          = {http://dx.doi.org/10.1016/j.autrev.2009.11.007},
  volume       = {9},
  year         = {2010},
}