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Familial association of pancreatic cancer with other malignancies in Swedish families

Hiripi, E.; Bermejo, J. Lorenzo; Li, X.; Sundquist, Jan LU and Hemminki, Kari LU (2009) In British Journal of Cancer 101(10). p.1792-1797
Abstract
BACKGROUND: The aim of this study was to characterise the familial association of pancreatic cancer with other malignancies. METHODS: Relative risks (RRs) of pancreatic cancer according to family history of cancer were calculated using the updated Swedish Family-Cancer Database, which includes over 11.5 million individuals. Estimates were based on Poisson regression. RRs of tumours for individuals with a parental history of pancreatic cancer were also estimated. RESULTS: The risk of pancreatic cancer was elevated in individuals with a parental history of cancers of the liver (RR 1.41; 95% CI 1.10-1.81), kidney (RR 1.37; 95% CI 1.06-1.76), lung (RR 1.50; 95% CI 1.27-1.79) and larynx (RR 1.98; 95% CI 1.19-3.28). Associations were also found... (More)
BACKGROUND: The aim of this study was to characterise the familial association of pancreatic cancer with other malignancies. METHODS: Relative risks (RRs) of pancreatic cancer according to family history of cancer were calculated using the updated Swedish Family-Cancer Database, which includes over 11.5 million individuals. Estimates were based on Poisson regression. RRs of tumours for individuals with a parental history of pancreatic cancer were also estimated. RESULTS: The risk of pancreatic cancer was elevated in individuals with a parental history of cancers of the liver (RR 1.41; 95% CI 1.10-1.81), kidney (RR 1.37; 95% CI 1.06-1.76), lung (RR 1.50; 95% CI 1.27-1.79) and larynx (RR 1.98; 95% CI 1.19-3.28). Associations were also found between parental history of pancreatic cancer and cancers of the small intestine, colon, breast, lung, testis and cervix in offspring. There was an increased risk of pancreatic cancer associated with early-onset breast cancer in siblings. CONCLUSION: Pancreatic cancer aggregates in families with several types of cancer. Smoking may contribute to the familial aggregation of pancreatic and lung tumours, and the familial clustering of pancreatic and breast cancer could be partially explained by inherited mutations in the BRCA2 gene. British Journal of Cancer (2009) 101, 1792-1797. doi: 10.1038/sj.bjc.6605363 www.bjcancer.com Published online 13 October 2009 (C) 2009 Cancer Research UK (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
familial risk, pancreatic cancer, family history
in
British Journal of Cancer
volume
101
issue
10
pages
1792 - 1797
publisher
Nature Publishing Group
external identifiers
  • wos:000271666400018
  • scopus:70449519323
ISSN
1532-1827
DOI
10.1038/sj.bjc.6605363
language
English
LU publication?
yes
id
24d96050-b540-4017-aacd-468d34b70663 (old id 1519595)
date added to LUP
2009-12-28 11:51:22
date last changed
2017-12-17 03:24:13
@article{24d96050-b540-4017-aacd-468d34b70663,
  abstract     = {BACKGROUND: The aim of this study was to characterise the familial association of pancreatic cancer with other malignancies. METHODS: Relative risks (RRs) of pancreatic cancer according to family history of cancer were calculated using the updated Swedish Family-Cancer Database, which includes over 11.5 million individuals. Estimates were based on Poisson regression. RRs of tumours for individuals with a parental history of pancreatic cancer were also estimated. RESULTS: The risk of pancreatic cancer was elevated in individuals with a parental history of cancers of the liver (RR 1.41; 95% CI 1.10-1.81), kidney (RR 1.37; 95% CI 1.06-1.76), lung (RR 1.50; 95% CI 1.27-1.79) and larynx (RR 1.98; 95% CI 1.19-3.28). Associations were also found between parental history of pancreatic cancer and cancers of the small intestine, colon, breast, lung, testis and cervix in offspring. There was an increased risk of pancreatic cancer associated with early-onset breast cancer in siblings. CONCLUSION: Pancreatic cancer aggregates in families with several types of cancer. Smoking may contribute to the familial aggregation of pancreatic and lung tumours, and the familial clustering of pancreatic and breast cancer could be partially explained by inherited mutations in the BRCA2 gene. British Journal of Cancer (2009) 101, 1792-1797. doi: 10.1038/sj.bjc.6605363 www.bjcancer.com Published online 13 October 2009 (C) 2009 Cancer Research UK},
  author       = {Hiripi, E. and Bermejo, J. Lorenzo and Li, X. and Sundquist, Jan and Hemminki, Kari},
  issn         = {1532-1827},
  keyword      = {familial risk,pancreatic cancer,family history},
  language     = {eng},
  number       = {10},
  pages        = {1792--1797},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Familial association of pancreatic cancer with other malignancies in Swedish families},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6605363},
  volume       = {101},
  year         = {2009},
}