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Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Buechner, Frederike L.; Bueno-de-Mesquita, H. Bas; Ros, Martine M.; Kampman, Ellen; Egevad, Lars; Overvad, Kim; Raaschou-Nielsen, Ole; Tjonneland, Anne; Roswall, Nina and Clavel-Chapelon, Francoise, et al. (2009) In International Journal of Cancer 125(11). p.2643-2651
Abstract
Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of... (More)
Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow-up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95-1.01). Borderline statistically significant lower bladder cancer risks were found among fever smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87-1.00 with increments of 100 g/day; calibrate HR = 0.92 95%CI 0.79-1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82-0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk. (c) 2009 UICC (Less)
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publication status
published
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keywords
bladder cancer, fruit, vegetables, EPIC
in
International Journal of Cancer
volume
125
issue
11
pages
2643 - 2651
publisher
John Wiley & Sons
external identifiers
  • wos:000271516500019
  • scopus:70350731128
ISSN
0020-7136
DOI
10.1002/ijc.24582
language
English
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yes
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036b8473-af29-49e0-862c-c964b3d4741c (old id 1520127)
date added to LUP
2009-12-28 10:08:40
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2017-01-01 04:23:19
@article{036b8473-af29-49e0-862c-c964b3d4741c,
  abstract     = {Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow-up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95-1.01). Borderline statistically significant lower bladder cancer risks were found among fever smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87-1.00 with increments of 100 g/day; calibrate HR = 0.92 95%CI 0.79-1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82-0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk. (c) 2009 UICC},
  author       = {Buechner, Frederike L. and Bueno-de-Mesquita, H. Bas and Ros, Martine M. and Kampman, Ellen and Egevad, Lars and Overvad, Kim and Raaschou-Nielsen, Ole and Tjonneland, Anne and Roswall, Nina and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Touillaud, Marina and Chang-Claude, Jenny and Kaaks, Rudolf and Boeing, Heiner and Weikert, Steffen and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Palli, Domenico and Sieri, Sabina and Vineis, Paolo and Tumino, Rosario and Panico, Salvatore and Vrieling, Alina and Peeters, Petra H. M. and van Gils, Carla H. and Lund, Eiliv and Gram, Inger T. and Engeset, Dagrun and Martinez, Carmen and Gonzalez, Carlos A. and Larranaga, Nerea and Ardanaz, Eva and Navarro, Carmen and Rodriguez, Laudina and Manjer, Jonas and Ehrnström, Roy and Hallmans, Goran and Ljungberg, Borje and Allen, Naomi E. and Roddam, Andrew W. and Bingham, Sheila and Khaw, Kay-Tee and Slimani, Nadia and Boffetta, Paolo and Jenab, Mazda and Mouw, Traci and Michaud, Dominique S. and Kiemeney, Lambertus A. L. M. and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {bladder cancer,fruit,vegetables,EPIC},
  language     = {eng},
  number       = {11},
  pages        = {2643--2651},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.24582},
  volume       = {125},
  year         = {2009},
}