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Wall shear stress variations in a 90-degree bifurcation in 3D pulsating flows.

Evegren, Philip LU ; Fuchs, Laszlo LU and Revstedt, Johan LU (2010) In Medical Engineering & Physics1994-01-01+01:00 32. p.189-202
Abstract
The exact role of fluid mechanics in the patho-physiological process of atherosclerosis has been a research topic over many years, yet without clear conclusive result. One has observed that morphological manifestations of the disease are found at some well-defined locations: certain vessel bifurcations and in curvatures. The flow in these regions is characterized by unsteadiness and often separation. Currently there are no complete theories that can explain the process since the different components in the process are not fully understood. Here we carry out detailed computations of the unsteady flow in an arterial segment typical to location of early appearance of arterial lesions. We study the wall shear stress (WSS) field variations near... (More)
The exact role of fluid mechanics in the patho-physiological process of atherosclerosis has been a research topic over many years, yet without clear conclusive result. One has observed that morphological manifestations of the disease are found at some well-defined locations: certain vessel bifurcations and in curvatures. The flow in these regions is characterized by unsteadiness and often separation. Currently there are no complete theories that can explain the process since the different components in the process are not fully understood. Here we carry out detailed computations of the unsteady flow in an arterial segment typical to location of early appearance of arterial lesions. We study the wall shear stress (WSS) field variations near a junction with the purpose of identifying fluid-mechanical parameters that can be related to sites of atheroslcerosis. The results show that regions associated with atherosclerosis experience highly elevated temporal- and spatial-derivatives of the WSS, also at less commonly known locations. Thus, large derivatives in time and space do not seem unique for the most common areas of atherosclerosis. Differences in WSS character between these locations are identified as differences in the time period of back flow as well as differences in the magnitude of the WSS derivatives. The data is presented in a way that facilitates understanding of the variations in WSS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Medical Engineering & Physics1994-01-01+01:00
volume
32
pages
189 - 202
publisher
Elsevier
external identifiers
  • wos:000276189800011
  • pmid:20034837
  • scopus:75749092904
ISSN
1873-4030
DOI
10.1016/j.medengphy.2009.11.008
language
English
LU publication?
yes
id
c963036b-e8ae-40f6-946e-96b5d806ffc1 (old id 1523313)
date added to LUP
2010-01-12 08:00:50
date last changed
2018-05-29 10:11:06
@article{c963036b-e8ae-40f6-946e-96b5d806ffc1,
  abstract     = {The exact role of fluid mechanics in the patho-physiological process of atherosclerosis has been a research topic over many years, yet without clear conclusive result. One has observed that morphological manifestations of the disease are found at some well-defined locations: certain vessel bifurcations and in curvatures. The flow in these regions is characterized by unsteadiness and often separation. Currently there are no complete theories that can explain the process since the different components in the process are not fully understood. Here we carry out detailed computations of the unsteady flow in an arterial segment typical to location of early appearance of arterial lesions. We study the wall shear stress (WSS) field variations near a junction with the purpose of identifying fluid-mechanical parameters that can be related to sites of atheroslcerosis. The results show that regions associated with atherosclerosis experience highly elevated temporal- and spatial-derivatives of the WSS, also at less commonly known locations. Thus, large derivatives in time and space do not seem unique for the most common areas of atherosclerosis. Differences in WSS character between these locations are identified as differences in the time period of back flow as well as differences in the magnitude of the WSS derivatives. The data is presented in a way that facilitates understanding of the variations in WSS.},
  author       = {Evegren, Philip and Fuchs, Laszlo and Revstedt, Johan},
  issn         = {1873-4030},
  language     = {eng},
  pages        = {189--202},
  publisher    = {Elsevier},
  series       = {Medical Engineering & Physics1994-01-01+01:00},
  title        = {Wall shear stress variations in a 90-degree bifurcation in 3D pulsating flows.},
  url          = {http://dx.doi.org/10.1016/j.medengphy.2009.11.008},
  volume       = {32},
  year         = {2010},
}