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Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.

Singh, Birendra LU ; Brant, Marta LU ; Kilian, Mogens; Hallström, Björn LU and Riesbeck, Kristian LU (2010) In Journal of Infectious Diseases 201. p.414-419
Abstract
Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
201
pages
414 - 419
publisher
Oxford University Press
external identifiers
  • WOS:000273441000015
  • PMID:20028233
  • Scopus:75649102522
ISSN
1537-6613
DOI
10.1086/649782
language
English
LU publication?
yes
id
b3ec66de-5530-414e-b39b-a9a23d30bf84 (old id 1523385)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20028233?dopt=Abstract
date added to LUP
2010-01-11 14:22:56
date last changed
2017-01-01 07:51:26
@article{b3ec66de-5530-414e-b39b-a9a23d30bf84,
  abstract     = {Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.},
  author       = {Singh, Birendra and Brant, Marta and Kilian, Mogens and Hallström, Björn and Riesbeck, Kristian},
  issn         = {1537-6613},
  language     = {eng},
  pages        = {414--419},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.},
  url          = {http://dx.doi.org/10.1086/649782},
  volume       = {201},
  year         = {2010},
}