Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.
Singh, Birendra LU ; Brant, Marta LU ; Kilian, Mogens ; Hallström, Björn LU and Riesbeck, Kristian LU
(2010)
In Journal of Infectious Diseases
201.
p.414-419
- Abstract
- Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1523385
- author
- Singh, Birendra
LU
; Brant, Marta
LU
; Kilian, Mogens
; Hallström, Björn
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Infectious Diseases
- volume
- 201
- pages
- 414 - 419
- publisher
- Oxford University Press
- external identifiers
-
- wos:000273441000015
- pmid:20028233
- scopus:75649102522
- pmid:20028233
- ISSN
- 1537-6613
- DOI
- 10.1086/649782
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Cell and Organism Biology (Closed 2011.) (011002100), Clinical Microbiology, Malmö (013011000)
- id
- b3ec66de-5530-414e-b39b-a9a23d30bf84 (old id 1523385)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20028233?dopt=Abstract
- date added to LUP
- 2016-04-04 09:34:27
- date last changed
- 2022-01-29 18:32:32
@article{b3ec66de-5530-414e-b39b-a9a23d30bf84,
abstract = {{Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.}},
author = {{Singh, Birendra and Brant, Marta and Kilian, Mogens and Hallström, Björn and Riesbeck, Kristian}},
issn = {{1537-6613}},
language = {{eng}},
pages = {{414--419}},
publisher = {{Oxford University Press}},
series = {{Journal of Infectious Diseases}},
title = {{Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.}},
url = {{http://dx.doi.org/10.1086/649782}},
doi = {{10.1086/649782}},
volume = {{201}},
year = {{2010}},
}