Ethnic Differences in Incidence of Type 1 Diabetes among Second-Generation Immigrants and Adoptees from Abroad.
(2010) In The Journal of clinical endocrinology and metabolism 95. p.847-850- Abstract
- Objective: The incidence of type 1 diabetes shows a large variation worldwide, but whether the causes are environmental or genetic has not been settled. We examine here the incidence of type 1 diabetes among second-generation immigrants and adoptees from abroad to disentangle genetic/ethnic vs. environmental influence, assuming adoptees from abroad have similar environmental exposures compared with the native Swedes, with the only difference in their genetic background. Methods: Second-generation immigrants and adoptees from abroad were retrieved from the MIGMED2 database, and they were followed up until the diagnosis of type 1 diabetes, death, or the end of study. Standardized incidence ratios (SIRs) were calculated for type 1 diabetes... (More)
- Objective: The incidence of type 1 diabetes shows a large variation worldwide, but whether the causes are environmental or genetic has not been settled. We examine here the incidence of type 1 diabetes among second-generation immigrants and adoptees from abroad to disentangle genetic/ethnic vs. environmental influence, assuming adoptees from abroad have similar environmental exposures compared with the native Swedes, with the only difference in their genetic background. Methods: Second-generation immigrants and adoptees from abroad were retrieved from the MIGMED2 database, and they were followed up until the diagnosis of type 1 diabetes, death, or the end of study. Standardized incidence ratios (SIRs) were calculated for type 1 diabetes among these immigrants compared with native Swedes. Results: A total of 1,050,569 children were defined as second-generation immigrants and the overall SIR of type 1 diabetes was significantly decreased. A decreased risk was observed for all countries of origin, with an exception for children with parents from Finland. A total of 51,557 children born in foreign countries were adopted by Swedes. Adoptees from Eastern Europe, Soviet countries, India, Pakistan, Afghanistan, East and Southeast Asia, Chile, and other Central and South American countries had a significantly decreased SIR. Conclusions: The decreased incidence of type 1 diabetes observed in some second-generation immigrants and adoptees from abroad strongly suggests that ethnic genetic heterogeneity could play an important role on type 1 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1523458
- author
- Ji, Jianguang
LU
; Hemminki, Kari LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 95
- pages
- 847 - 850
- publisher
- Oxford University Press
- external identifiers
-
- wos:000274298200048
- pmid:20022988
- scopus:76149138455
- pmid:20022988
- ISSN
- 1945-7197
- DOI
- 10.1210/jc.2009-1818
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Psychiatry/Primary Care/Public Health (013240500), Family medicine, psychiatric epidemiology and migration (013240037), Family medicine, cardiovascular epidemiology and lifestyle (013240038), Family Medicine (013241010)
- id
- 7215359e-68d1-4ff9-92db-39f9a6f060e6 (old id 1523458)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20022988?dopt=Abstract
- date added to LUP
- 2016-04-04 09:15:53
- date last changed
- 2022-01-29 17:06:05
@article{7215359e-68d1-4ff9-92db-39f9a6f060e6, abstract = {{Objective: The incidence of type 1 diabetes shows a large variation worldwide, but whether the causes are environmental or genetic has not been settled. We examine here the incidence of type 1 diabetes among second-generation immigrants and adoptees from abroad to disentangle genetic/ethnic vs. environmental influence, assuming adoptees from abroad have similar environmental exposures compared with the native Swedes, with the only difference in their genetic background. Methods: Second-generation immigrants and adoptees from abroad were retrieved from the MIGMED2 database, and they were followed up until the diagnosis of type 1 diabetes, death, or the end of study. Standardized incidence ratios (SIRs) were calculated for type 1 diabetes among these immigrants compared with native Swedes. Results: A total of 1,050,569 children were defined as second-generation immigrants and the overall SIR of type 1 diabetes was significantly decreased. A decreased risk was observed for all countries of origin, with an exception for children with parents from Finland. A total of 51,557 children born in foreign countries were adopted by Swedes. Adoptees from Eastern Europe, Soviet countries, India, Pakistan, Afghanistan, East and Southeast Asia, Chile, and other Central and South American countries had a significantly decreased SIR. Conclusions: The decreased incidence of type 1 diabetes observed in some second-generation immigrants and adoptees from abroad strongly suggests that ethnic genetic heterogeneity could play an important role on type 1 diabetes.}}, author = {{Ji, Jianguang and Hemminki, Kari and Sundquist, Jan and Sundquist, Kristina}}, issn = {{1945-7197}}, language = {{eng}}, pages = {{847--850}}, publisher = {{Oxford University Press}}, series = {{The Journal of clinical endocrinology and metabolism}}, title = {{Ethnic Differences in Incidence of Type 1 Diabetes among Second-Generation Immigrants and Adoptees from Abroad.}}, url = {{http://dx.doi.org/10.1210/jc.2009-1818}}, doi = {{10.1210/jc.2009-1818}}, volume = {{95}}, year = {{2010}}, }