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Metabolic fate of C-14-labelled chlorinated and non-chlorinated fatty acids in goldfish (Carassius auratus)

Björn van Praagh, Helena LU ; Ewald, Göran LU ; Sundin, P; Wesén, Clas LU ; Skramstad, J and Froyen, P (2004) In Fish Physiology & Biochemistry 30(1). p.13-20
Abstract
In order to study the metabolic fate of chlorinated fatty acids in fish, goldfish were fed either 9,10-dichlorostearic acid or oleic acid, chosen as the unchlorinated analogue, both radiolabelled at either the carboxyl (1st) or the terminal (18th) carbon of the fatty acid chain. By keeping the fish in hermetically closed aquaria, all the respired, assimilated and excreted radioactivity could be accounted for. Fish fed 9,10-dichlorostearic acid labelled in the terminal end respired radioactive CO2 to a much lower degree than fish fed the other test compounds. As a consequence, the radioactivity bound in lipids was higher in the group of fish fed dichlorostearic acid labelled in the terminal end. It is suggested that the chlorine atoms in... (More)
In order to study the metabolic fate of chlorinated fatty acids in fish, goldfish were fed either 9,10-dichlorostearic acid or oleic acid, chosen as the unchlorinated analogue, both radiolabelled at either the carboxyl (1st) or the terminal (18th) carbon of the fatty acid chain. By keeping the fish in hermetically closed aquaria, all the respired, assimilated and excreted radioactivity could be accounted for. Fish fed 9,10-dichlorostearic acid labelled in the terminal end respired radioactive CO2 to a much lower degree than fish fed the other test compounds. As a consequence, the radioactivity bound in lipids was higher in the group of fish fed dichlorostearic acid labelled in the terminal end. It is suggested that the chlorine atoms in the middle of the carbon chain obstruct the metabolic turn-over of 9,10-dichlorostearic acid, which may have an impact on the residence time of these compounds in the ecosystem. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Fish Physiology & Biochemistry
volume
30
issue
1
pages
13 - 20
publisher
Springer
external identifiers
  • wos:000228874700002
  • scopus:19444386645
ISSN
0920-1742
DOI
10.1007/s10695-004-4153-2
language
English
LU publication?
yes
id
af56998a-dee7-440d-ae44-2d6f44878ec0 (old id 152659)
date added to LUP
2007-06-25 10:27:45
date last changed
2017-01-01 05:09:41
@article{af56998a-dee7-440d-ae44-2d6f44878ec0,
  abstract     = {In order to study the metabolic fate of chlorinated fatty acids in fish, goldfish were fed either 9,10-dichlorostearic acid or oleic acid, chosen as the unchlorinated analogue, both radiolabelled at either the carboxyl (1st) or the terminal (18th) carbon of the fatty acid chain. By keeping the fish in hermetically closed aquaria, all the respired, assimilated and excreted radioactivity could be accounted for. Fish fed 9,10-dichlorostearic acid labelled in the terminal end respired radioactive CO2 to a much lower degree than fish fed the other test compounds. As a consequence, the radioactivity bound in lipids was higher in the group of fish fed dichlorostearic acid labelled in the terminal end. It is suggested that the chlorine atoms in the middle of the carbon chain obstruct the metabolic turn-over of 9,10-dichlorostearic acid, which may have an impact on the residence time of these compounds in the ecosystem.},
  author       = {Björn van Praagh, Helena and Ewald, Göran and Sundin, P and Wesén, Clas and Skramstad, J and Froyen, P},
  issn         = {0920-1742},
  language     = {eng},
  number       = {1},
  pages        = {13--20},
  publisher    = {Springer},
  series       = {Fish Physiology & Biochemistry},
  title        = {Metabolic fate of C-14-labelled chlorinated and non-chlorinated fatty acids in goldfish (Carassius auratus)},
  url          = {http://dx.doi.org/10.1007/s10695-004-4153-2},
  volume       = {30},
  year         = {2004},
}