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Physiological development of a mixed metabolic and respiratory umbilical cord blood acidemia with advancing gestational age.

Wiberg, Nana LU orcid ; Källén, Karin LU and Olofsson, Per LU (2006) In Early Human Development 82(9). p.583-589
Abstract
Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P < 0.05 being significant. Results: Gestational age correlated negatively with arterial pH and HCO3- and positively with pCO(2) and base deficit. Venous blood showed corresponding changes except for pCO(2), which was independent of gestational age. Arterial pCO(2), but not venous, correlated positively with birthweight deviation from the mean. The fractional fetal CO2 production per birthweight unit and... (More)
Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P < 0.05 being significant. Results: Gestational age correlated negatively with arterial pH and HCO3- and positively with pCO(2) and base deficit. Venous blood showed corresponding changes except for pCO(2), which was independent of gestational age. Arterial pCO(2), but not venous, correlated positively with birthweight deviation from the mean. The fractional fetal CO2 production per birthweight unit and the fractional placental CO2 clearance per placental weight unit were not correlated with gestational age. Conclusions: A mixed respiratory and metabolic cord blood acidemia develops with advancing gestational age. The respiratory component depends on an increased 'CO2 load' fetus and not on deterioration of placental gas exchange. The etiology of the metabolic component is yet unknown. (c) 2006 Published by Elsevier Ireland Ltd. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood gases, umbilical cord, acidosis, gestational age, fetal, pregnancy
in
Early Human Development
volume
82
issue
9
pages
583 - 589
publisher
Elsevier
external identifiers
  • pmid:16472947
  • wos:000241092200002
  • scopus:33747883774
ISSN
1872-6232
DOI
10.1016/j.earlhumdev.2005.12.005
language
English
LU publication?
yes
id
d86796ae-bb5c-4a58-b8f1-5544ddd54a5d (old id 153535)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16472947&dopt=Abstract
date added to LUP
2016-04-01 16:54:40
date last changed
2021-10-03 03:16:32
@article{d86796ae-bb5c-4a58-b8f1-5544ddd54a5d,
  abstract     = {Objective: To investigate respiratory and metabolic components of gestational age-dependent umbilical cord blood gas changes. Study design: Cord blood gases were determined in 1336 vigorous singletons with uncomplicated cephatic vaginal delivery at 37-43 weeks. Linear regression analysis and non-parametric statistics were used with a P &lt; 0.05 being significant. Results: Gestational age correlated negatively with arterial pH and HCO3- and positively with pCO(2) and base deficit. Venous blood showed corresponding changes except for pCO(2), which was independent of gestational age. Arterial pCO(2), but not venous, correlated positively with birthweight deviation from the mean. The fractional fetal CO2 production per birthweight unit and the fractional placental CO2 clearance per placental weight unit were not correlated with gestational age. Conclusions: A mixed respiratory and metabolic cord blood acidemia develops with advancing gestational age. The respiratory component depends on an increased 'CO2 load' fetus and not on deterioration of placental gas exchange. The etiology of the metabolic component is yet unknown. (c) 2006 Published by Elsevier Ireland Ltd.},
  author       = {Wiberg, Nana and Källén, Karin and Olofsson, Per},
  issn         = {1872-6232},
  language     = {eng},
  number       = {9},
  pages        = {583--589},
  publisher    = {Elsevier},
  series       = {Early Human Development},
  title        = {Physiological development of a mixed metabolic and respiratory umbilical cord blood acidemia with advancing gestational age.},
  url          = {https://lup.lub.lu.se/search/files/4816759/625336.pdf},
  doi          = {10.1016/j.earlhumdev.2005.12.005},
  volume       = {82},
  year         = {2006},
}