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Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition

Hermann, Silke; Rohrmann, Sabine; Linseisen, Jakob; Nieters, Alexandra; Khan, Aneire; Gallo, Valentina; Overvad, Kim; Tjonneland, Anne; Raaschou-Nielsen, Ole and Bergmann, Manuela M., et al. (2010) In Journal of Cancer Research and Clinical Oncology 136(1). p.71-77
Abstract
Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of... (More)
Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02-1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27-0.79) versus lowest educational level. No association was found for HL. We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded. (Less)
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publication status
published
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keywords
Cohort study, Education, Lymphomas, SES
in
Journal of Cancer Research and Clinical Oncology
volume
136
issue
1
pages
71 - 77
publisher
Springer
external identifiers
  • wos:000271981600009
  • scopus:71449088460
ISSN
1432-1335
DOI
10.1007/s00432-009-0638-9
language
English
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yes
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1fef380a-da31-4b39-8ea1-aea3c2c1a1cf (old id 1535706)
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2010-01-27 11:21:49
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2018-05-29 10:00:33
@article{1fef380a-da31-4b39-8ea1-aea3c2c1a1cf,
  abstract     = {Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02-1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27-0.79) versus lowest educational level. No association was found for HL. We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded.},
  author       = {Hermann, Silke and Rohrmann, Sabine and Linseisen, Jakob and Nieters, Alexandra and Khan, Aneire and Gallo, Valentina and Overvad, Kim and Tjonneland, Anne and Raaschou-Nielsen, Ole and Bergmann, Manuela M. and Boeing, Heiner and Becker, Nikolaus and Kaaks, Rudolf and Bueno-de-Mesquita, H. Bas and May, Anne M. and Vermeulen, Roel C. H. and Bingham, Sheila and Khaw, Kay-Tee and Key, Timothy J. and Travis, Ruth C. and Trichopoulou, Antonia and Georgila, Christina and Triantafylou, Dimitra and Celentano, Egidio and Krogh, Vittorio and Masala, Giovanna and Tumino, Rosario and Agudo, Antonio and Altzibar, Jone M. and Ardanaz, Eva and Martinez-Garcia, Carmen and Argueelles Suarez, Marcial Vicente and Jose Tormo, Maria and Braaten, Tonje and Lund, Eiliv and Manjer, Jonas and Zackrisson, Sophia and Hallmans, Goran and Malmer, Beatrice and Boffetta, Paolo and Brennan, Paul and Slimani, Nadia and Vineis, Paolo and Riboli, Elio},
  issn         = {1432-1335},
  keyword      = {Cohort study,Education,Lymphomas,SES},
  language     = {eng},
  number       = {1},
  pages        = {71--77},
  publisher    = {Springer},
  series       = {Journal of Cancer Research and Clinical Oncology},
  title        = {Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1007/s00432-009-0638-9},
  volume       = {136},
  year         = {2010},
}