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Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties.

Ahrén, Bo LU (2006) In Expert Opinion on Investigational Drugs 15(4). p.431-442
Abstract
Vilclagliptin is a competitive and reversible inhibitor of dipeptidyl peptidase-4. Dipeptidyl peptidase-4 inhibitors act mainly by preventing the rapid degradation of glucagon-like peptide-1. In clinical trials, vildagliptin improves glycaemic control both as monotherapy and in combination with metformin for periods of :! 52 weeks in subjects with Type 2 diabetes. This is evident by reduced fasting and prandial glucose levels, and reduced glycosylated haemoglobin levels. Vilclagliptin acts by increasing active glucagon-like peptide-1, improving p-cell function and inhibiting glucagon secretion. Furthermore, vildagliptin has proven to be safe and tolerable, with a low occurrence of hypoglycaemia. Further studies are now required to evaluate... (More)
Vilclagliptin is a competitive and reversible inhibitor of dipeptidyl peptidase-4. Dipeptidyl peptidase-4 inhibitors act mainly by preventing the rapid degradation of glucagon-like peptide-1. In clinical trials, vildagliptin improves glycaemic control both as monotherapy and in combination with metformin for periods of :! 52 weeks in subjects with Type 2 diabetes. This is evident by reduced fasting and prandial glucose levels, and reduced glycosylated haemoglobin levels. Vilclagliptin acts by increasing active glucagon-like peptide-1, improving p-cell function and inhibiting glucagon secretion. Furthermore, vildagliptin has proven to be safe and tolerable, with a low occurrence of hypoglycaemia. Further studies are now required to evaluate its long-term durability, effects, safety and tolerability in comparison with other antidiabetic agents and in different patient subgroups. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GLP-1, DPP-4, vildagliptin, Type 2 diabetes, glycaemic control
in
Expert Opinion on Investigational Drugs
volume
15
issue
4
pages
431 - 442
publisher
Ashley Publications
external identifiers
  • wos:000236651300010
  • pmid:16548792
  • scopus:33645707285
ISSN
1744-7658
DOI
10.1517/13543784.15.4.431
language
English
LU publication?
yes
id
e422269d-3cfc-4949-a86e-f2e2e927046c (old id 154511)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16548792&dopt=Abstract
date added to LUP
2016-04-01 11:40:54
date last changed
2020-12-08 05:22:22
@article{e422269d-3cfc-4949-a86e-f2e2e927046c,
  abstract     = {Vilclagliptin is a competitive and reversible inhibitor of dipeptidyl peptidase-4. Dipeptidyl peptidase-4 inhibitors act mainly by preventing the rapid degradation of glucagon-like peptide-1. In clinical trials, vildagliptin improves glycaemic control both as monotherapy and in combination with metformin for periods of :! 52 weeks in subjects with Type 2 diabetes. This is evident by reduced fasting and prandial glucose levels, and reduced glycosylated haemoglobin levels. Vilclagliptin acts by increasing active glucagon-like peptide-1, improving p-cell function and inhibiting glucagon secretion. Furthermore, vildagliptin has proven to be safe and tolerable, with a low occurrence of hypoglycaemia. Further studies are now required to evaluate its long-term durability, effects, safety and tolerability in comparison with other antidiabetic agents and in different patient subgroups.},
  author       = {Ahrén, Bo},
  issn         = {1744-7658},
  language     = {eng},
  number       = {4},
  pages        = {431--442},
  publisher    = {Ashley Publications},
  series       = {Expert Opinion on Investigational Drugs},
  title        = {Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties.},
  url          = {http://dx.doi.org/10.1517/13543784.15.4.431},
  doi          = {10.1517/13543784.15.4.431},
  volume       = {15},
  year         = {2006},
}