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Vitamins B2 and B6 and Genetic Polymorphisms Related to One-Carbon Metabolism as Risk Factors for Gastric Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

Eussen, Simone J. P. M.; Vollset, Stein Emil; Hustad, Steinar; Midttun, Oivind; Meyer, Klaus; Fredriksen, Ase; Ueland, Per Magne; Jenab, Mazda; Slimani, Nadia and Ferrari, Pietro, et al. (2010) In Cancer Epidemiology Biomarkers & Prevention 19(1). p.28-38
Abstract
B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin 132 status, whereas the sum of pyridoxal... (More)
B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin 132 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for CC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P-trend) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, <0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with CC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and CC risk, which is borderline significant, and a significant inverse association between vitamin B6 and CC risk. Cancer Epidemiol Biomarkers Prev; 19(1); 28-38. (C)2010 AACR. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
19
issue
1
pages
28 - 38
publisher
American Association for Cancer Research
external identifiers
  • wos:000273586700004
  • scopus:74549222230
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-08-1096
language
English
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73f48b94-a303-4b6b-9bf6-65051fe367c7 (old id 1547553)
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2010-02-23 14:03:46
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@article{73f48b94-a303-4b6b-9bf6-65051fe367c7,
  abstract     = {B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort, cases (n = 235) and controls (n = 601) were matched for study center, age, sex, and time of blood sampling. B2 and B6 species were measured in plasma, and the sum of riboflavin and flavin mononucleotide was used as the main exposure variable for vitamin 132 status, whereas the sum of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid was used to define vitamin B6 status. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for CC risk were calculated with conditional logistic regression, adjusted for Helicobacter pylori infection status and smoking status. Adjusted relative risks per quartile (95% confidence interval, P-trend) were 0.85 (0.72-1.01, 0.06) for vitamin B2 and 0.78 (0.65-0.93, &lt;0.01) for vitamin B6. Both relations were stronger in individuals with severe chronic atrophic gastritis. The polymorphisms were not associated with CC risk and did not modify the observed vitamin-cancer associations. In summary, results from this large European cohort study showed an inverse association between vitamin B2 and CC risk, which is borderline significant, and a significant inverse association between vitamin B6 and CC risk. Cancer Epidemiol Biomarkers Prev; 19(1); 28-38. (C)2010 AACR.},
  author       = {Eussen, Simone J. P. M. and Vollset, Stein Emil and Hustad, Steinar and Midttun, Oivind and Meyer, Klaus and Fredriksen, Ase and Ueland, Per Magne and Jenab, Mazda and Slimani, Nadia and Ferrari, Pietro and Agudo, Antonio and Sala, Nuria and Capella, Gabriel and Del Giudice, Giuseppe and Palli, Domenico and Boeing, Heiner and Weikert, Cornelia and Bueno-de-Mesquita, H. Bas and Buechner, Frederike L. and Carneiro, Fatima and Berrino, Franco and Vineis, Paolo and Tumino, Rosario and Panico, Salvatore and Berglund, Göran and Manjer, Jonas and Stenling, Roger and Hallmans, Goeran and Martinez, Carmen and Arrizola, Larraitz and Barricarte, Aurelio and Navarro, Carmen and Rodriguez, Laudina and Bingham, Sheila and Linseisen, Jakob and Kaaks, Rudolf and Overvad, Kim and Tjonneland, Anne and Peeters, Petra H. M. and Numans, Mattijs E. and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Morois, Sophie and Trichopoulou, Antonia and Lund, Eiliv and Plebani, Mario and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {1538-7755},
  language     = {eng},
  number       = {1},
  pages        = {28--38},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Vitamins B2 and B6 and Genetic Polymorphisms Related to One-Carbon Metabolism as Risk Factors for Gastric Adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-08-1096},
  volume       = {19},
  year         = {2010},
}