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Levothyroxine treatment reduces thyroid size in children and adolescents with chronic autoimmune thyroiditis.

Svensson, Johan LU ; Ericsson, Ulla-Britt ; Nilsson, Paul ; Olsson, Catherine ; Jonsson, Bjorn ; Lindberg, Bengt LU and Ivarsson, Sten LU (2006) In Journal of Clinical Endocrinology and Metabolism 91(5). p.1729-1734
Abstract
Context: The use of levothyroxine to reduce thyroid size in pediatric patients with goiter due to chronic autoimmune thyroiditis (AIT) remains controversial. In overtly hypothyroid patients, reductions in thyroid volume have been reported, whereas the effect in subclinically hypothyroid and euthyroid patients is less clear.



Objective: The objective of the study was to evaluate the effect of levothyroxine treatment on thyroid size (determined with thyroid ultrasonography) in children and adolescents with AIT.



Design and Setting: This study included patients with AIT treated at a university hospital outpatient clinic between 1987 and 2004.



Patients: Ninety children with AIT (73 girls... (More)
Context: The use of levothyroxine to reduce thyroid size in pediatric patients with goiter due to chronic autoimmune thyroiditis (AIT) remains controversial. In overtly hypothyroid patients, reductions in thyroid volume have been reported, whereas the effect in subclinically hypothyroid and euthyroid patients is less clear.



Objective: The objective of the study was to evaluate the effect of levothyroxine treatment on thyroid size (determined with thyroid ultrasonography) in children and adolescents with AIT.



Design and Setting: This study included patients with AIT treated at a university hospital outpatient clinic between 1987 and 2004.



Patients: Ninety children with AIT (73 girls and 17 boys, aged 6.1–17.7 yr) were included in the study.



Intervention: Intervention was treatment with levothyroxine for a median 2.8 yr (range 0.5–10.2).



Main Outcome Measure: Change in thyroid volume SD score (SDS) during the study period was measured.



Results: Median thyroid volume SDS was reduced in patients euthyroid (–0.4 SDS, P < 0.001), subclinically hypothyroid (–1.4 SDS, P < 0.001), and overtly hypothyroid (–1.8 SDS, P < 0.002) at diagnosis of AIT. Both hypothyroid and euthyroid patients with goiter (thyroid volume > 2.0 SDS) at baseline reduced their median thyroid volume SDS (–1.6 and –0.9, respectively, P < 0.001). Hypothyroid patients without goiter also reduced median thyroid volume SDS (–1.2, P < 0.004), whereas no change was noticed in euthyroid children without goiter.



Conclusions: Levothyroxine treatment is effective in reducing thyroid volume in pediatric patients and is suggested in treatment of goiter caused by AIT, especially in cases of hypothyroid, but also in euthyroid children. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
91
issue
5
pages
1729 - 1734
publisher
Oxford University Press
external identifiers
  • wos:000237330000018
  • pmid:16507633
  • scopus:33646386154
  • pmid:16507633
ISSN
1945-7197
DOI
10.1210/jc.2005-2400
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Diabetes and Celiac Unit (013241540), Paediatric Endocrinology Research Group (013243010)
id
425878bc-996d-4466-9ef6-f27370a50ea3 (old id 154889)
date added to LUP
2016-04-01 16:29:08
date last changed
2020-12-08 03:05:02
@article{425878bc-996d-4466-9ef6-f27370a50ea3,
  abstract     = {Context: The use of levothyroxine to reduce thyroid size in pediatric patients with goiter due to chronic autoimmune thyroiditis (AIT) remains controversial. In overtly hypothyroid patients, reductions in thyroid volume have been reported, whereas the effect in subclinically hypothyroid and euthyroid patients is less clear.<br/><br>
<br/><br>
Objective: The objective of the study was to evaluate the effect of levothyroxine treatment on thyroid size (determined with thyroid ultrasonography) in children and adolescents with AIT.<br/><br>
<br/><br>
Design and Setting: This study included patients with AIT treated at a university hospital outpatient clinic between 1987 and 2004.<br/><br>
<br/><br>
Patients: Ninety children with AIT (73 girls and 17 boys, aged 6.1–17.7 yr) were included in the study.<br/><br>
<br/><br>
Intervention: Intervention was treatment with levothyroxine for a median 2.8 yr (range 0.5–10.2).<br/><br>
<br/><br>
Main Outcome Measure: Change in thyroid volume SD score (SDS) during the study period was measured.<br/><br>
<br/><br>
Results: Median thyroid volume SDS was reduced in patients euthyroid (–0.4 SDS, P &lt; 0.001), subclinically hypothyroid (–1.4 SDS, P &lt; 0.001), and overtly hypothyroid (–1.8 SDS, P &lt; 0.002) at diagnosis of AIT. Both hypothyroid and euthyroid patients with goiter (thyroid volume &gt; 2.0 SDS) at baseline reduced their median thyroid volume SDS (–1.6 and –0.9, respectively, P &lt; 0.001). Hypothyroid patients without goiter also reduced median thyroid volume SDS (–1.2, P &lt; 0.004), whereas no change was noticed in euthyroid children without goiter.<br/><br>
<br/><br>
Conclusions: Levothyroxine treatment is effective in reducing thyroid volume in pediatric patients and is suggested in treatment of goiter caused by AIT, especially in cases of hypothyroid, but also in euthyroid children.},
  author       = {Svensson, Johan and Ericsson, Ulla-Britt and Nilsson, Paul and Olsson, Catherine and Jonsson, Bjorn and Lindberg, Bengt and Ivarsson, Sten},
  issn         = {1945-7197},
  language     = {eng},
  number       = {5},
  pages        = {1729--1734},
  publisher    = {Oxford University Press},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Levothyroxine treatment reduces thyroid size in children and adolescents with chronic autoimmune thyroiditis.},
  url          = {http://dx.doi.org/10.1210/jc.2005-2400},
  doi          = {10.1210/jc.2005-2400},
  volume       = {91},
  year         = {2006},
}