Advanced

Biokinetics Of 18F-Choline Studied In Four Prostate Cancer Patients

Uusijärvi, Helena LU ; Nilsson, L-E; Bjartell, Anders LU and Mattsson, Sören LU (2010) In Radiation Protection Dosimetry 139(1-3). p.240-244
Abstract
Biokinetic data are important when calculating the absorbed dose to the patients and can also be used to find the optimal time between injection and imaging. To the authors' knowledge, there are no published biokinetic data in humans for (18)F-choline, except some distribution data at single time points. Four patients with suspicion of metastases due to biochemical recurrence (measurable prostate-specific antigen in plasma) after radical prostatectomy were injected with (18)F-choline. Four whole-body PET/CT images were taken with 1 h interval, starting immediately after injection. Blood samples were taken and all urine was collected for 3.5 h. The corrected decay activity content in the kidneys was 22-37 % higher immediately after... (More)
Biokinetic data are important when calculating the absorbed dose to the patients and can also be used to find the optimal time between injection and imaging. To the authors' knowledge, there are no published biokinetic data in humans for (18)F-choline, except some distribution data at single time points. Four patients with suspicion of metastases due to biochemical recurrence (measurable prostate-specific antigen in plasma) after radical prostatectomy were injected with (18)F-choline. Four whole-body PET/CT images were taken with 1 h interval, starting immediately after injection. Blood samples were taken and all urine was collected for 3.5 h. The corrected decay activity content in the kidneys was 22-37 % higher immediately after injection when compared with the later time points. The highest activity concentration was found in kidneys (43 kBq ml(-1)). The organ with highest activity content was the liver (11 % of injected activity, % IA). Thirty minutes after the injection 4-16 % IA was left in the blood. Less than 9 % IA was excreted with the urine during the first 3.5 h after injection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
139
issue
1-3
pages
240 - 244
publisher
Nuclear Technology Publishing
external identifiers
  • wos:000277738200043
  • pmid:20150231
  • scopus:77953305288
ISSN
1742-3406
DOI
10.1093/rpd/ncq024
language
English
LU publication?
yes
id
b6123d29-91ab-472c-88cb-ac0d22ca7ffe (old id 1552731)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20150231?dopt=Abstract
date added to LUP
2010-03-02 22:25:37
date last changed
2018-05-29 10:23:17
@article{b6123d29-91ab-472c-88cb-ac0d22ca7ffe,
  abstract     = {Biokinetic data are important when calculating the absorbed dose to the patients and can also be used to find the optimal time between injection and imaging. To the authors' knowledge, there are no published biokinetic data in humans for (18)F-choline, except some distribution data at single time points. Four patients with suspicion of metastases due to biochemical recurrence (measurable prostate-specific antigen in plasma) after radical prostatectomy were injected with (18)F-choline. Four whole-body PET/CT images were taken with 1 h interval, starting immediately after injection. Blood samples were taken and all urine was collected for 3.5 h. The corrected decay activity content in the kidneys was 22-37 % higher immediately after injection when compared with the later time points. The highest activity concentration was found in kidneys (43 kBq ml(-1)). The organ with highest activity content was the liver (11 % of injected activity, % IA). Thirty minutes after the injection 4-16 % IA was left in the blood. Less than 9 % IA was excreted with the urine during the first 3.5 h after injection.},
  author       = {Uusijärvi, Helena and Nilsson, L-E and Bjartell, Anders and Mattsson, Sören},
  issn         = {1742-3406},
  language     = {eng},
  number       = {1-3},
  pages        = {240--244},
  publisher    = {Nuclear Technology Publishing},
  series       = {Radiation Protection Dosimetry},
  title        = {Biokinetics Of 18F-Choline Studied In Four Prostate Cancer Patients},
  url          = {http://dx.doi.org/10.1093/rpd/ncq024},
  volume       = {139},
  year         = {2010},
}