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Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC

Rundle, Andrew; Richie, John; Steindorf, Karen; Peluso, Marco; Overvad, Kim; Raaschou-Nielsen, Ole; Clavel-Chapelon, Francoise; Linseisen, Jacob P.; Boeing, Heiner and Trichopoulou, Antonia, et al. (2010) In Biomarkers 15(1). p.20-30
Abstract
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by <SU32</SUP-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 mu mol GSH g<SU-1</SU haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI... (More)
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by <SU32</SUP-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 mu mol GSH g<SU-1</SU haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.</. (Less)
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@article{dbd242e4-7908-42f5-9bb3-297f7065644e,
  abstract     = {The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by &lt;SU32&lt;/SUP-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 mu mol GSH g&lt;SU-1&lt;/SU haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.&lt;/.},
  author       = {Rundle, Andrew and Richie, John and Steindorf, Karen and Peluso, Marco and Overvad, Kim and Raaschou-Nielsen, Ole and Clavel-Chapelon, Francoise and Linseisen, Jacob P. and Boeing, Heiner and Trichopoulou, Antonia and Palli, Domenico and Krogh, Vittorio and Tumino, Rosario and Panico, Salvatore and Bueno-De-Mesquita, Hendrik B. and Peeters, Petra H. and Lund, Eiliv and Gonzalez, Carlos A. and Martinez, Carmen and Dorronsoro, Miren and Barricarte, Aurelio and Jose Tormo, M. and Quiros, Jose R. and Agudo, Antonio and Berglund, Göran and Jarvholm, Bengt and Bingham, Sheila and Key, Timothy J. and Gormally, Emmanuelle and Saracci, Rodolfo and Kaaks, Rudolf and Riboli, Elio and Vineis, Paolo},
  issn         = {1366-5804},
  keyword      = {biomarkers,Physical activity,lung cancer,molecular epidemiology},
  language     = {eng},
  number       = {1},
  pages        = {20--30},
  publisher    = {Taylor & Francis},
  series       = {Biomarkers},
  title        = {Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC},
  url          = {http://dx.doi.org/10.3109/13547500903186452},
  volume       = {15},
  year         = {2010},
}