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A controlled study of consumption of beta-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects

Cugnet-Anceau, Christine; Nazare, Julie-Anne; Biörklund, Maria LU ; Le Coquil, Elodie; Sassolas, Agnes; Sothier, Monique; Holm, Jorgen; Landin-Olsson, Mona LU ; Önning, Gunilla LU and Laville, Martine, et al. (2010) In British Journal of Nutrition 103(3). p.422-428
Abstract
Type 2 diabetes is associated with a higher cardiovascular risk and there has been a growing interest in using dietary intervention to improve lipid profile and glucose control. The present work aims at analysing the effects of the enrichment of a normal diet with beta-glucan (3-5 g/d) in free-living type 2 diabetic subjects for 2 months, using a palatable soup. This trial was a parallel, placebo-controlled, double-blinded randomised study performed in fifty-three type 2 diabetic subjects. During a 3-week run-in period, subjects daily consumed a ready meal control soup (without beta-glucan). For the following 8 weeks, Subjects were randomly assigned to consume daily either a control soup or a beta-glucan soup. Changes in lipid profile... (More)
Type 2 diabetes is associated with a higher cardiovascular risk and there has been a growing interest in using dietary intervention to improve lipid profile and glucose control. The present work aims at analysing the effects of the enrichment of a normal diet with beta-glucan (3-5 g/d) in free-living type 2 diabetic subjects for 2 months, using a palatable soup. This trial was a parallel, placebo-controlled, double-blinded randomised study performed in fifty-three type 2 diabetic subjects. During a 3-week run-in period, subjects daily consumed a ready meal control soup (without beta-glucan). For the following 8 weeks, Subjects were randomly assigned to consume daily either a control soup or a beta-glucan soup. Changes in lipid profile (total cholesterol (TC), HDL- and LDL-cholesterol (HDLc and LDLc), apo B and TAG) and in glucose control (HbA1c and fasting glucose) were measured. There was no significant alteration in lipid profile in the two groups (TC, HDLc. LDLc and apo B). TAG decreased significantly in the beta-glucan group compared with the control group (-0.12 (SD 0.38) v. 0.12 (SD 0.44)mmol/l, P=0.03). HbA1c and fasting glucose were not reduced in any group. A single daily ingestion of 3-5 g beta-glucan, as required by official dietary recommendations for 8 weeks did not change the lipid profile and HbA1c in type 2 diabetic subjects. To improve the metabolic profile of type 2 diabetic subjects in the long term, the quantity, the food vectors and the tolerability of P-glucan products may be re-evaluated. (Less)
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Contribution to journal
publication status
published
subject
keywords
Long-term, Type 2 diabetes, HbA1c, beta-Glucan, Lipid profile, intervention
in
British Journal of Nutrition
volume
103
issue
3
pages
422 - 428
publisher
Cambridge University Press
external identifiers
  • wos:000274689400016
  • scopus:77449117330
ISSN
1475-2662
DOI
10.1017/S0007114509991875
language
English
LU publication?
yes
id
e0383c1b-c701-4f13-a9ce-01c1ca1c0a44 (old id 1568651)
date added to LUP
2010-03-23 09:07:39
date last changed
2018-05-29 12:01:10
@article{e0383c1b-c701-4f13-a9ce-01c1ca1c0a44,
  abstract     = {Type 2 diabetes is associated with a higher cardiovascular risk and there has been a growing interest in using dietary intervention to improve lipid profile and glucose control. The present work aims at analysing the effects of the enrichment of a normal diet with beta-glucan (3-5 g/d) in free-living type 2 diabetic subjects for 2 months, using a palatable soup. This trial was a parallel, placebo-controlled, double-blinded randomised study performed in fifty-three type 2 diabetic subjects. During a 3-week run-in period, subjects daily consumed a ready meal control soup (without beta-glucan). For the following 8 weeks, Subjects were randomly assigned to consume daily either a control soup or a beta-glucan soup. Changes in lipid profile (total cholesterol (TC), HDL- and LDL-cholesterol (HDLc and LDLc), apo B and TAG) and in glucose control (HbA1c and fasting glucose) were measured. There was no significant alteration in lipid profile in the two groups (TC, HDLc. LDLc and apo B). TAG decreased significantly in the beta-glucan group compared with the control group (-0.12 (SD 0.38) v. 0.12 (SD 0.44)mmol/l, P=0.03). HbA1c and fasting glucose were not reduced in any group. A single daily ingestion of 3-5 g beta-glucan, as required by official dietary recommendations for 8 weeks did not change the lipid profile and HbA1c in type 2 diabetic subjects. To improve the metabolic profile of type 2 diabetic subjects in the long term, the quantity, the food vectors and the tolerability of P-glucan products may be re-evaluated.},
  author       = {Cugnet-Anceau, Christine and Nazare, Julie-Anne and Biörklund, Maria and Le Coquil, Elodie and Sassolas, Agnes and Sothier, Monique and Holm, Jorgen and Landin-Olsson, Mona and Önning, Gunilla and Laville, Martine and Moulin, Philippe},
  issn         = {1475-2662},
  keyword      = {Long-term,Type 2 diabetes,HbA1c,beta-Glucan,Lipid profile,intervention},
  language     = {eng},
  number       = {3},
  pages        = {422--428},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {A controlled study of consumption of beta-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects},
  url          = {http://dx.doi.org/10.1017/S0007114509991875},
  volume       = {103},
  year         = {2010},
}