Advanced

The Accuracy of Short Clinical Rating Scales in Neuropathologically Diagnosed Dementia.

Gustafson, Lars LU ; Englund, Elisabet LU ; Brunnström, Hans LU ; Brun, Arne LU ; Erikson, Catarina LU ; Warkentin, Siegbert LU and Passant, Ulla LU (2010) In The American Journal of Geriatric Psychiatry Apr 7. p.810-820
Abstract
OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hundred nine patients with dementia referred for clinical evaluation and follow-up. METHODS:: The diagnostic scores in a set of three short clinical rating scales for AD, FTD, and VaD were evaluated against NP diagnoses. RESULTS:: The sensitivity and specificity of the AD scale were 0.80 and 0.87, respectively, of the FTD scale 0.93 and 0.92,... (More)
OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hundred nine patients with dementia referred for clinical evaluation and follow-up. METHODS:: The diagnostic scores in a set of three short clinical rating scales for AD, FTD, and VaD were evaluated against NP diagnoses. RESULTS:: The sensitivity and specificity of the AD scale were 0.80 and 0.87, respectively, of the FTD scale 0.93 and 0.92, respectively, and of the Hachinski Ischemic Score (HIS, VaD diagnosis) 0.69 and 0.92, respectively. Cases with mixed AD/VaD generally presented a combination of high AD and ischemic scores. A preferred cutoff score of six was identified for both the AD and FTD scales. CONCLUSIONS:: All three clinical rating scales showed a high sensitivity and specificity, in close agreement with final NP diagnosis-for the HIS a moderate sensitivity. These scales may thus be considered good diagnostic tools and are recommended for clinical and research center settings. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The American Journal of Geriatric Psychiatry
volume
Apr 7
pages
810 - 820
publisher
Elsevier
external identifiers
  • wos:000281610000005
  • pmid:20220603
  • scopus:77956395388
ISSN
1545-7214
DOI
10.1097/JGP.0b013e3181cdef7a
language
English
LU publication?
yes
id
6f94f265-fc3d-4dbd-9625-c7da3913d620 (old id 1582314)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20220603?dopt=Abstract
date added to LUP
2010-04-07 16:00:53
date last changed
2018-05-29 10:08:33
@article{6f94f265-fc3d-4dbd-9625-c7da3913d620,
  abstract     = {OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hundred nine patients with dementia referred for clinical evaluation and follow-up. METHODS:: The diagnostic scores in a set of three short clinical rating scales for AD, FTD, and VaD were evaluated against NP diagnoses. RESULTS:: The sensitivity and specificity of the AD scale were 0.80 and 0.87, respectively, of the FTD scale 0.93 and 0.92, respectively, and of the Hachinski Ischemic Score (HIS, VaD diagnosis) 0.69 and 0.92, respectively. Cases with mixed AD/VaD generally presented a combination of high AD and ischemic scores. A preferred cutoff score of six was identified for both the AD and FTD scales. CONCLUSIONS:: All three clinical rating scales showed a high sensitivity and specificity, in close agreement with final NP diagnosis-for the HIS a moderate sensitivity. These scales may thus be considered good diagnostic tools and are recommended for clinical and research center settings.},
  author       = {Gustafson, Lars and Englund, Elisabet and Brunnström, Hans and Brun, Arne and Erikson, Catarina and Warkentin, Siegbert and Passant, Ulla},
  issn         = {1545-7214},
  language     = {eng},
  pages        = {810--820},
  publisher    = {Elsevier},
  series       = {The American Journal of Geriatric Psychiatry},
  title        = {The Accuracy of Short Clinical Rating Scales in Neuropathologically Diagnosed Dementia.},
  url          = {http://dx.doi.org/10.1097/JGP.0b013e3181cdef7a},
  volume       = {Apr 7},
  year         = {2010},
}