The Accuracy of Short Clinical Rating Scales in Neuropathologically Diagnosed Dementia.
(2010) In The American Journal of Geriatric Psychiatry Apr 7. p.810-820- Abstract
- OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hundred nine patients with dementia referred for clinical evaluation and follow-up. METHODS:: The diagnostic scores in a set of three short clinical rating scales for AD, FTD, and VaD were evaluated against NP diagnoses. RESULTS:: The sensitivity and specificity of the AD scale were 0.80 and 0.87, respectively, of the FTD scale 0.93 and 0.92,... (More)
- OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hundred nine patients with dementia referred for clinical evaluation and follow-up. METHODS:: The diagnostic scores in a set of three short clinical rating scales for AD, FTD, and VaD were evaluated against NP diagnoses. RESULTS:: The sensitivity and specificity of the AD scale were 0.80 and 0.87, respectively, of the FTD scale 0.93 and 0.92, respectively, and of the Hachinski Ischemic Score (HIS, VaD diagnosis) 0.69 and 0.92, respectively. Cases with mixed AD/VaD generally presented a combination of high AD and ischemic scores. A preferred cutoff score of six was identified for both the AD and FTD scales. CONCLUSIONS:: All three clinical rating scales showed a high sensitivity and specificity, in close agreement with final NP diagnosis-for the HIS a moderate sensitivity. These scales may thus be considered good diagnostic tools and are recommended for clinical and research center settings. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1582314
- author
- Gustafson, Lars
LU
; Englund, Elisabet
LU
; Brunnström, Hans LU
; Brun, Arne LU ; Erikson, Catarina LU ; Warkentin, Siegbert LU and Passant, Ulla LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The American Journal of Geriatric Psychiatry
- volume
- Apr 7
- pages
- 810 - 820
- publisher
- Elsevier
- external identifiers
-
- wos:000281610000005
- pmid:20220603
- scopus:77956395388
- pmid:20220603
- ISSN
- 1545-7214
- DOI
- 10.1097/JGP.0b013e3181cdef7a
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Department of Psychogeriatrics (013304000)
- id
- 6f94f265-fc3d-4dbd-9625-c7da3913d620 (old id 1582314)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20220603?dopt=Abstract
- date added to LUP
- 2016-04-04 08:41:15
- date last changed
- 2022-01-29 03:48:24
@article{6f94f265-fc3d-4dbd-9625-c7da3913d620, abstract = {{OBJECTIVE:: The overall aim was to evaluate to what extent the diagnosis of dementia subtypes, obtained by three clinical rating scales, concurred with postmortem neuropathologic (NP) diagnosis of Alzheimer disease (AD), frontotemporal dementia (FTD), vascular dementia (VaD) and mixed AD/VaD. DESIGN:: A prospective longitudinal clinical work-up with postmortem NP examination. PARTICIPANTS:: Two hundred nine patients with dementia referred for clinical evaluation and follow-up. METHODS:: The diagnostic scores in a set of three short clinical rating scales for AD, FTD, and VaD were evaluated against NP diagnoses. RESULTS:: The sensitivity and specificity of the AD scale were 0.80 and 0.87, respectively, of the FTD scale 0.93 and 0.92, respectively, and of the Hachinski Ischemic Score (HIS, VaD diagnosis) 0.69 and 0.92, respectively. Cases with mixed AD/VaD generally presented a combination of high AD and ischemic scores. A preferred cutoff score of six was identified for both the AD and FTD scales. CONCLUSIONS:: All three clinical rating scales showed a high sensitivity and specificity, in close agreement with final NP diagnosis-for the HIS a moderate sensitivity. These scales may thus be considered good diagnostic tools and are recommended for clinical and research center settings.}}, author = {{Gustafson, Lars and Englund, Elisabet and Brunnström, Hans and Brun, Arne and Erikson, Catarina and Warkentin, Siegbert and Passant, Ulla}}, issn = {{1545-7214}}, language = {{eng}}, pages = {{810--820}}, publisher = {{Elsevier}}, series = {{The American Journal of Geriatric Psychiatry}}, title = {{The Accuracy of Short Clinical Rating Scales in Neuropathologically Diagnosed Dementia.}}, url = {{http://dx.doi.org/10.1097/JGP.0b013e3181cdef7a}}, doi = {{10.1097/JGP.0b013e3181cdef7a}}, volume = {{Apr 7}}, year = {{2010}}, }