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Eyeing tumorigenesis: Notch signaling and epigenetic silencing of Rb in Drosophila.

Axelson, Håkan LU (2006) In BioEssays 28(7). p.692-695
Abstract
Notch signaling plays an essential role in the processes of embryogenesis and cellular differentiation, and it is believed that the oncogenic effects of dysregulated Notch signaling are an anomalous reflection of the normal functions of this cascade. Nonetheless, the cellular events associated with oncogenic Notch signaling have thus far remained elusive. In a recent report, Ferres-Marco et al.((1)) described how they used the Drosphila eye as a model system and found that elevated Notch signaling in combination with activation of components of the Polycomb complex of transcriptional repressors led to metastatic growth of tumors through epigenetic silencing of the Rbf gene. Rbf is the Drosophila homologue of the retinoblastoma... (More)
Notch signaling plays an essential role in the processes of embryogenesis and cellular differentiation, and it is believed that the oncogenic effects of dysregulated Notch signaling are an anomalous reflection of the normal functions of this cascade. Nonetheless, the cellular events associated with oncogenic Notch signaling have thus far remained elusive. In a recent report, Ferres-Marco et al.((1)) described how they used the Drosphila eye as a model system and found that elevated Notch signaling in combination with activation of components of the Polycomb complex of transcriptional repressors led to metastatic growth of tumors through epigenetic silencing of the Rbf gene. Rbf is the Drosophila homologue of the retinoblastoma tumor-suppressor gene (Rb), thus it represents a novel link between Notch signaling, tumor growth and metastasis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BioEssays
volume
28
issue
7
pages
692 - 695
publisher
John Wiley and Sons
external identifiers
  • wos:000239322900003
  • scopus:33747505460
  • pmid:16850405
ISSN
0265-9247
DOI
10.1002/bies.20428
language
English
LU publication?
yes
id
1185ed03-5823-4f45-ac3c-4a3ec57d4bcb (old id 158889)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16850405&dopt=Abstract
date added to LUP
2016-04-01 12:13:39
date last changed
2021-01-06 06:33:57
@article{1185ed03-5823-4f45-ac3c-4a3ec57d4bcb,
  abstract     = {Notch signaling plays an essential role in the processes of embryogenesis and cellular differentiation, and it is believed that the oncogenic effects of dysregulated Notch signaling are an anomalous reflection of the normal functions of this cascade. Nonetheless, the cellular events associated with oncogenic Notch signaling have thus far remained elusive. In a recent report, Ferres-Marco et al.((1)) described how they used the Drosphila eye as a model system and found that elevated Notch signaling in combination with activation of components of the Polycomb complex of transcriptional repressors led to metastatic growth of tumors through epigenetic silencing of the Rbf gene. Rbf is the Drosophila homologue of the retinoblastoma tumor-suppressor gene (Rb), thus it represents a novel link between Notch signaling, tumor growth and metastasis.},
  author       = {Axelson, Håkan},
  issn         = {0265-9247},
  language     = {eng},
  number       = {7},
  pages        = {692--695},
  publisher    = {John Wiley and Sons},
  series       = {BioEssays},
  title        = {Eyeing tumorigenesis: Notch signaling and epigenetic silencing of Rb in Drosophila.},
  url          = {http://dx.doi.org/10.1002/bies.20428},
  doi          = {10.1002/bies.20428},
  volume       = {28},
  year         = {2006},
}