Bone Turnover Markers and Prediction of Fracture: A Prospective Follow-Up Study of 1040 Elderly Women for a Mean of 9 Years
(2010) In Journal of Bone and Mineral Research 25(2). p.393-403- Abstract
- Osteoporosis is characterized by compromised bone mass and strength, predisposing to an increased risk of fracture. Increased bone metabolism has been suggested to be a risk factor for fracture. The aim of this study was to evaluate whether baseline bone turnover markers are associated with long-term incidence of fracture in a population-based sample of 1040 women who were 75 years old (Malmo OPRA study). Seven bone markers (S-TRACP5b, S-CTX-1, S-OC[1-49], S-TotaIOC, S-cOC, S-boneALP, and urinary osteocalcin) were measured at baseline and 1-year follow-up visit. During the mean follow-up of 9.0 years (range 7.4-10.9), 363 women sustained at least one fracture of any type, including 116 hip fractures and 103 clinical vertebral fractures.... (More)
- Osteoporosis is characterized by compromised bone mass and strength, predisposing to an increased risk of fracture. Increased bone metabolism has been suggested to be a risk factor for fracture. The aim of this study was to evaluate whether baseline bone turnover markers are associated with long-term incidence of fracture in a population-based sample of 1040 women who were 75 years old (Malmo OPRA study). Seven bone markers (S-TRACP5b, S-CTX-1, S-OC[1-49], S-TotaIOC, S-cOC, S-boneALP, and urinary osteocalcin) were measured at baseline and 1-year follow-up visit. During the mean follow-up of 9.0 years (range 7.4-10.9), 363 women sustained at least one fracture of any type, including 116 hip fractures and 103 clinical vertebral fractures. High S-TRACP5b and S-CTX-1 levels were associated with increased risk of any fracture with hazard ratios [HRs (95% confidence interval)] of 1.16 (1.04-1.29) and 1.13 (1.01-1.27) per SD increase, respectively. They also were associated with increased risk of clinical vertebral fracture with HRs of 1.22 (1.01-1.48) and 1.32 (1.05-1.67), respectively. Markers were not associated with risk for hip fracture. Results were similar when we used resorption markers, including urinary osteocalcin, measured at the 1-year visit or an average of the two measurements. The HRs were highest for any fracture in the beginning of the follow-up period, 2.5 years from baseline. For vertebral fractures, the association was more pronounced and lasted for a longer period of time, at least for 5 years. In conclusion, elevated levels of S-TRACP5b, S-CTX-1, and urinary osteocalcin are associated with increased fracture risk for up to a decade in elderly women. (C) 2010 American Society for Bone and Mineral Research. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1589521
- author
- Ivaska, Kaisa LU ; Gerdhem, Paul LU ; Vaananen, H Kalervo ; Åkesson, Kristina LU and Obrant, Karl LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- PROSPECTIVE, TRACP5b, LONGITUDINAL, BONE TURNOVER MARKERS, OSTEOPOROTIC FRACTURE
- in
- Journal of Bone and Mineral Research
- volume
- 25
- issue
- 2
- pages
- 393 - 403
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000275215500024
- scopus:77953452345
- pmid:19961336
- ISSN
- 1523-4681
- DOI
- 10.1359/jbmr.091006
- language
- English
- LU publication?
- yes
- id
- 00c1d052-67af-4056-906b-7139723a7866 (old id 1589521)
- date added to LUP
- 2016-04-01 10:00:34
- date last changed
- 2024-05-05 02:24:38
@article{00c1d052-67af-4056-906b-7139723a7866, abstract = {{Osteoporosis is characterized by compromised bone mass and strength, predisposing to an increased risk of fracture. Increased bone metabolism has been suggested to be a risk factor for fracture. The aim of this study was to evaluate whether baseline bone turnover markers are associated with long-term incidence of fracture in a population-based sample of 1040 women who were 75 years old (Malmo OPRA study). Seven bone markers (S-TRACP5b, S-CTX-1, S-OC[1-49], S-TotaIOC, S-cOC, S-boneALP, and urinary osteocalcin) were measured at baseline and 1-year follow-up visit. During the mean follow-up of 9.0 years (range 7.4-10.9), 363 women sustained at least one fracture of any type, including 116 hip fractures and 103 clinical vertebral fractures. High S-TRACP5b and S-CTX-1 levels were associated with increased risk of any fracture with hazard ratios [HRs (95% confidence interval)] of 1.16 (1.04-1.29) and 1.13 (1.01-1.27) per SD increase, respectively. They also were associated with increased risk of clinical vertebral fracture with HRs of 1.22 (1.01-1.48) and 1.32 (1.05-1.67), respectively. Markers were not associated with risk for hip fracture. Results were similar when we used resorption markers, including urinary osteocalcin, measured at the 1-year visit or an average of the two measurements. The HRs were highest for any fracture in the beginning of the follow-up period, 2.5 years from baseline. For vertebral fractures, the association was more pronounced and lasted for a longer period of time, at least for 5 years. In conclusion, elevated levels of S-TRACP5b, S-CTX-1, and urinary osteocalcin are associated with increased fracture risk for up to a decade in elderly women. (C) 2010 American Society for Bone and Mineral Research.}}, author = {{Ivaska, Kaisa and Gerdhem, Paul and Vaananen, H Kalervo and Åkesson, Kristina and Obrant, Karl}}, issn = {{1523-4681}}, keywords = {{PROSPECTIVE; TRACP5b; LONGITUDINAL; BONE TURNOVER MARKERS; OSTEOPOROTIC FRACTURE}}, language = {{eng}}, number = {{2}}, pages = {{393--403}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Bone and Mineral Research}}, title = {{Bone Turnover Markers and Prediction of Fracture: A Prospective Follow-Up Study of 1040 Elderly Women for a Mean of 9 Years}}, url = {{http://dx.doi.org/10.1359/jbmr.091006}}, doi = {{10.1359/jbmr.091006}}, volume = {{25}}, year = {{2010}}, }