Glutamate decarboxylase antibody levels predict rate of β-cell decline in adult-onset diabetes
(1995) In Diabetes Research and Clinical Practice 27(2). p.133-140- Abstract
Glutamate decarboxylase autoantibodies (GAD65Ab) and β-cell function were evaluated at and 3 years after diabetes onset in consecutive subjects over 15 years of age. At onset, 21 32 (66%) insulin-treated patients (mean age 43, range 16-79 years) had GAD65Ab; all GAD65Ab persisted 3 years later. At onset, 20 82 (24%) non-insulin-treated patients (mean age 56, range 20-79 years) had GAD65Ab. Of those with persistent GAD65Ab, 8 non-insulin-treated and 11 insulin-treated patients consented to follow-up glucose and glucagon stimulation tests. For non-insulin-treated patients, quantitative GAD65Ab index at onset correlated inversely with 1+3 min C-peptide response to glucose (r = -0.68, P < 0.05) and to glucagon (r = -0.79, P < 0.05) 3... (More)
Glutamate decarboxylase autoantibodies (GAD65Ab) and β-cell function were evaluated at and 3 years after diabetes onset in consecutive subjects over 15 years of age. At onset, 21 32 (66%) insulin-treated patients (mean age 43, range 16-79 years) had GAD65Ab; all GAD65Ab persisted 3 years later. At onset, 20 82 (24%) non-insulin-treated patients (mean age 56, range 20-79 years) had GAD65Ab. Of those with persistent GAD65Ab, 8 non-insulin-treated and 11 insulin-treated patients consented to follow-up glucose and glucagon stimulation tests. For non-insulin-treated patients, quantitative GAD65Ab index at onset correlated inversely with 1+3 min C-peptide response to glucose (r = -0.68, P < 0.05) and to glucagon (r = -0.79, P < 0.05) 3 years later. Those with high (> 0.50) initial GAD65Ab index had lower C-peptide (fasting, 1+3 min after glucose and after glucagon) 3 years later, versus those with low (<0.50) initial GAD65Ab index (P < 0.05). In conclusion, not only did GAD65Ab presence predict future insulin dependence, but higher GAD65Ab levels may mark more rapid decline in β-cell function in apparent non-insulin-dependent diabetes.
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- author
- Gottsäter, A. LU ; Landin-Olsson, M. LU ; Lernmark, Å LU ; Fernlund, P. LU ; Sundkvist, G. LU and Hagopian, W. A.
- organization
- publishing date
- 1995-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autoantigen, Autoimmunity, Glutamate decarboxylase (GAD), β-Cell function
- in
- Diabetes Research and Clinical Practice
- volume
- 27
- issue
- 2
- pages
- 133 - 140
- publisher
- Elsevier
- external identifiers
-
- pmid:7607051
- scopus:0028958719
- ISSN
- 0168-8227
- DOI
- 10.1016/0168-8227(95)01026-A
- language
- English
- LU publication?
- yes
- id
- 15af2242-858c-4261-8559-623b020b8c8a
- date added to LUP
- 2019-09-11 08:54:20
- date last changed
- 2024-03-13 08:08:35
@article{15af2242-858c-4261-8559-623b020b8c8a, abstract = {{<p>Glutamate decarboxylase autoantibodies (GAD65Ab) and β-cell function were evaluated at and 3 years after diabetes onset in consecutive subjects over 15 years of age. At onset, 21 32 (66%) insulin-treated patients (mean age 43, range 16-79 years) had GAD65Ab; all GAD65Ab persisted 3 years later. At onset, 20 82 (24%) non-insulin-treated patients (mean age 56, range 20-79 years) had GAD65Ab. Of those with persistent GAD65Ab, 8 non-insulin-treated and 11 insulin-treated patients consented to follow-up glucose and glucagon stimulation tests. For non-insulin-treated patients, quantitative GAD65Ab index at onset correlated inversely with 1+3 min C-peptide response to glucose (r = -0.68, P < 0.05) and to glucagon (r = -0.79, P < 0.05) 3 years later. Those with high (> 0.50) initial GAD65Ab index had lower C-peptide (fasting, 1+3 min after glucose and after glucagon) 3 years later, versus those with low (<0.50) initial GAD65Ab index (P < 0.05). In conclusion, not only did GAD65Ab presence predict future insulin dependence, but higher GAD65Ab levels may mark more rapid decline in β-cell function in apparent non-insulin-dependent diabetes.</p>}}, author = {{Gottsäter, A. and Landin-Olsson, M. and Lernmark, Å and Fernlund, P. and Sundkvist, G. and Hagopian, W. A.}}, issn = {{0168-8227}}, keywords = {{Autoantigen; Autoimmunity; Glutamate decarboxylase (GAD); β-Cell function}}, language = {{eng}}, month = {{01}}, number = {{2}}, pages = {{133--140}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{Glutamate decarboxylase antibody levels predict rate of β-cell decline in adult-onset diabetes}}, url = {{http://dx.doi.org/10.1016/0168-8227(95)01026-A}}, doi = {{10.1016/0168-8227(95)01026-A}}, volume = {{27}}, year = {{1995}}, }