Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity.
Lindqvist, Daniel LU ; Janelidze, Shorena LU ; Hagell, Peter LU ; Erhardt, Sophie ; Samuelsson, Martin LU ; Minthon, Lennart LU ; Hansson, Oskar LU
; Björkqvist, Maria
LU
; Träskman Bendz, Lil
LU
and Brundin, Lena
LU
(2009)
In Biological Psychiatry
66.
p.287-292
- Abstract
- BACKGROUND: Depressive disorders are associated with immune system alterations that can be detected in the blood. Cytokine concentrations in cerebrospinal fluid (CSF) and their relationship to aspects of suicidality have previously not been investigated. METHODS: We measured interleukin-1beta, interleukin-6 (IL-6), interleukin-8, and tumor necrosis factor-alpha (TNF-alpha) in CSF and plasma of suicide attempters (n = 63) and healthy control subjects (n = 47). Patients were classified according to diagnosis and violent or nonviolent suicide attempt. We evaluated suicidal ideation and depressive symptoms using the Suicide Assessment Scale and the Montgomery-Asberg Depression Rating Scale (MADRS). We also analyzed the relation between... (More)
- BACKGROUND: Depressive disorders are associated with immune system alterations that can be detected in the blood. Cytokine concentrations in cerebrospinal fluid (CSF) and their relationship to aspects of suicidality have previously not been investigated. METHODS: We measured interleukin-1beta, interleukin-6 (IL-6), interleukin-8, and tumor necrosis factor-alpha (TNF-alpha) in CSF and plasma of suicide attempters (n = 63) and healthy control subjects (n = 47). Patients were classified according to diagnosis and violent or nonviolent suicide attempt. We evaluated suicidal ideation and depressive symptoms using the Suicide Assessment Scale and the Montgomery-Asberg Depression Rating Scale (MADRS). We also analyzed the relation between cytokines and monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in CSF, as well as the integrity of the blood-brain barrier as reflected by the CSF:serum albumin ratio. RESULTS: IL-6 in CSF was significantly higher in suicide attempters than in healthy control subjects. Patients who performed violent suicide attempts displayed the highest IL-6. Furthermore, there was a significant positive correlation between MADRS scores and CSF IL-6 levels in all patients. IL-6 and TNF-alpha correlated significantly with 5-HIAA and HVA in CSF, but not with MHPG. Cytokine levels in plasma and CSF were not associated, and patients with increased blood-brain barrier permeability did not exhibit elevated cytokine levels. CONCLUSIONS: We propose a role for CSF IL-6 in the symptomatology of suicidal behavior, possibly through mechanisms involving alterations of dopamine and serotonin metabolism. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367964
- author
- Lindqvist, Daniel
LU
; Janelidze, Shorena
LU
; Hagell, Peter
LU
; Erhardt, Sophie
; Samuelsson, Martin
LU
; Minthon, Lennart
LU
; Hansson, Oskar
LU
; Björkqvist, Maria
LU
; Träskman Bendz, Lil
LU
and Brundin, Lena
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biological Psychiatry
- volume
- 66
- pages
- 287 - 292
- publisher
- Elsevier
- external identifiers
-
- wos:000267961600014
- pmid:19268915
- scopus:67649406060
- pmid:19268915
- ISSN
- 0006-3223
- DOI
- 10.1016/j.biopsych.2009.01.030
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Psychiatry/Primary Care/Public Health (013240500), Translational Neuroendocrinology (013210010), Neurosurgery (013026000), Psychiatry (Lund) (013303000), Caring Sciences (Closed 2012) (016514020), Clinical Microbiology, Malmö (013011000)
- id
- 15c79755-07ca-4421-aef7-dd02494ce206 (old id 1367964)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19268915?dopt=Abstract
- date added to LUP
- 2016-04-04 08:10:29
- date last changed
- 2023-09-19 14:37:02
@article{15c79755-07ca-4421-aef7-dd02494ce206,
abstract = {{BACKGROUND: Depressive disorders are associated with immune system alterations that can be detected in the blood. Cytokine concentrations in cerebrospinal fluid (CSF) and their relationship to aspects of suicidality have previously not been investigated. METHODS: We measured interleukin-1beta, interleukin-6 (IL-6), interleukin-8, and tumor necrosis factor-alpha (TNF-alpha) in CSF and plasma of suicide attempters (n = 63) and healthy control subjects (n = 47). Patients were classified according to diagnosis and violent or nonviolent suicide attempt. We evaluated suicidal ideation and depressive symptoms using the Suicide Assessment Scale and the Montgomery-Asberg Depression Rating Scale (MADRS). We also analyzed the relation between cytokines and monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in CSF, as well as the integrity of the blood-brain barrier as reflected by the CSF:serum albumin ratio. RESULTS: IL-6 in CSF was significantly higher in suicide attempters than in healthy control subjects. Patients who performed violent suicide attempts displayed the highest IL-6. Furthermore, there was a significant positive correlation between MADRS scores and CSF IL-6 levels in all patients. IL-6 and TNF-alpha correlated significantly with 5-HIAA and HVA in CSF, but not with MHPG. Cytokine levels in plasma and CSF were not associated, and patients with increased blood-brain barrier permeability did not exhibit elevated cytokine levels. CONCLUSIONS: We propose a role for CSF IL-6 in the symptomatology of suicidal behavior, possibly through mechanisms involving alterations of dopamine and serotonin metabolism.}},
author = {{Lindqvist, Daniel and Janelidze, Shorena and Hagell, Peter and Erhardt, Sophie and Samuelsson, Martin and Minthon, Lennart and Hansson, Oskar and Björkqvist, Maria and Träskman Bendz, Lil and Brundin, Lena}},
issn = {{0006-3223}},
language = {{eng}},
pages = {{287--292}},
publisher = {{Elsevier}},
series = {{Biological Psychiatry}},
title = {{Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity.}},
url = {{http://dx.doi.org/10.1016/j.biopsych.2009.01.030}},
doi = {{10.1016/j.biopsych.2009.01.030}},
volume = {{66}},
year = {{2009}},
}