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Effects of epidural and intrathecal application of collagenase in the lumbar spine : an experimental study in rabbits

Olmarker, K; Rydevik, B; Dahlin, L B LU ; Danielsen, N LU and Nordborg, C (1987) In Spine 12(5). p.82-477
Abstract

An experimental model is described in which collagenase in different concentrations and volumes were applied epidurally or intrathecally in the rabbit lumbar spine. This made it possible to study the tissue effects in a situation similar to that of collagenase leaking from a disc or accidental epidural or intrathecal injection at chemonucleolysis. Epidurally applied collagenase, in higher concentration, caused a local thinning of the dura. This effect was reduced at lower concentrations and volumes. Intrathecally injected collagenase, even in small amounts, caused intrathecal hemorrhage and acute paraplegia in the hind limbs. Therefore, in the clinical situation, intrathecal injection of collagenase must be avoided.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Dura Mater, Female, Injections, Epidural, Injections, Spinal, Intervertebral Disc Chemolysis, Lumbar Vertebrae, Male, Microbial Collagenase, Permeability, Rabbits, Spinal Cord, Spinal Nerve Roots, Journal Article, Research Support, Non-U.S. Gov't
in
Spine
volume
12
issue
5
pages
82 - 477
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0023196325
ISSN
0362-2436
language
English
LU publication?
no
id
15da6539-358a-45bb-a7d9-7312650d8198
date added to LUP
2017-10-13 14:12:29
date last changed
2017-11-06 16:02:27
@article{15da6539-358a-45bb-a7d9-7312650d8198,
  abstract     = {<p>An experimental model is described in which collagenase in different concentrations and volumes were applied epidurally or intrathecally in the rabbit lumbar spine. This made it possible to study the tissue effects in a situation similar to that of collagenase leaking from a disc or accidental epidural or intrathecal injection at chemonucleolysis. Epidurally applied collagenase, in higher concentration, caused a local thinning of the dura. This effect was reduced at lower concentrations and volumes. Intrathecally injected collagenase, even in small amounts, caused intrathecal hemorrhage and acute paraplegia in the hind limbs. Therefore, in the clinical situation, intrathecal injection of collagenase must be avoided.</p>},
  author       = {Olmarker, K and Rydevik, B and Dahlin, L B and Danielsen, N and Nordborg, C},
  issn         = {0362-2436},
  keyword      = {Animals,Dura Mater,Female,Injections, Epidural,Injections, Spinal,Intervertebral Disc Chemolysis,Lumbar Vertebrae,Male,Microbial Collagenase,Permeability,Rabbits,Spinal Cord,Spinal Nerve Roots,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {5},
  pages        = {82--477},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Spine},
  title        = {Effects of epidural and intrathecal application of collagenase in the lumbar spine : an experimental study in rabbits},
  volume       = {12},
  year         = {1987},
}