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Pharmacoeconomics of factor dosing in the haemophilia population.

Berntorp, Erik LU (2006) In Haemophilia 12 Suppl 4. p.70-73
Abstract
Treatment of haemophilia is extremely costly due to the short biological half-life of infused factor and pricing issues. This paper examines the impact of different dosing schedules on factor consumption, via a review of literature on dosing regimens used for prophylaxis with a focus on pharmacokinetics (PK). Pharmacokinetics were found to have an important role for pharmacoeconomics in factor dosing both for assessment of the treatment and for developing new treatment protocols but the clinical response to treatment must always guide the dosing schedule. In order to better understand pharmacoeconomics during prophylaxis, controlled prospective studies are needed but much can also be learned from studies of existing cohorts that have been... (More)
Treatment of haemophilia is extremely costly due to the short biological half-life of infused factor and pricing issues. This paper examines the impact of different dosing schedules on factor consumption, via a review of literature on dosing regimens used for prophylaxis with a focus on pharmacokinetics (PK). Pharmacokinetics were found to have an important role for pharmacoeconomics in factor dosing both for assessment of the treatment and for developing new treatment protocols but the clinical response to treatment must always guide the dosing schedule. In order to better understand pharmacoeconomics during prophylaxis, controlled prospective studies are needed but much can also be learned from studies of existing cohorts that have been treated for decades. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
factor dosing, pharmacoeconomics, haemophilia, pharmacokinetics
in
Haemophilia
volume
12 Suppl 4
pages
70 - 73
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000240660200013
  • scopus:33748803037
ISSN
1351-8216
DOI
10.1111/j.1365-2516.2006.01337.x
language
English
LU publication?
yes
id
5ef8cd4a-dc12-4916-aac1-4880c191ba67 (old id 160934)
alternative location
http://www.ingentaconnect.com/content/bsc/haem/2006/00000012/A00401s4/art00013
date added to LUP
2016-04-01 12:11:44
date last changed
2020-01-12 09:23:36
@article{5ef8cd4a-dc12-4916-aac1-4880c191ba67,
  abstract     = {Treatment of haemophilia is extremely costly due to the short biological half-life of infused factor and pricing issues. This paper examines the impact of different dosing schedules on factor consumption, via a review of literature on dosing regimens used for prophylaxis with a focus on pharmacokinetics (PK). Pharmacokinetics were found to have an important role for pharmacoeconomics in factor dosing both for assessment of the treatment and for developing new treatment protocols but the clinical response to treatment must always guide the dosing schedule. In order to better understand pharmacoeconomics during prophylaxis, controlled prospective studies are needed but much can also be learned from studies of existing cohorts that have been treated for decades.},
  author       = {Berntorp, Erik},
  issn         = {1351-8216},
  language     = {eng},
  pages        = {70--73},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {Pharmacoeconomics of factor dosing in the haemophilia population.},
  url          = {http://dx.doi.org/10.1111/j.1365-2516.2006.01337.x},
  doi          = {10.1111/j.1365-2516.2006.01337.x},
  volume       = {12 Suppl 4},
  year         = {2006},
}