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Women who gave birth to girls with Turner syndrome: maternal and neonatal characteristics

Hagman, A.; Wennerholm, U. -B.; Källén, Karin LU ; Barrenas, M. -L.; Landin-Wilhelmsen, K.; Hanson, C. and Bryman, I. (2010) In Human Reproduction 25(6). p.1553-1560
Abstract
Background: The aim was to identify maternal risk factors in women giving birth to girls with Turner syndrome (TS) and to describe the characteristics of newborns with TS. Methods: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register. Between 1973 and 2005, 494 children with TS were born. Maternal age, parity, height, smoking habits and neonatal characteristics; mode of delivery, gestational age, size at birth and Apgar score, were compared with women in the general population who gave birth to girls during the same period. Results: More women with advanced maternal age (40+) delivered girls with TS, 3.2% when compared with 1.8% in the general population [OR 1.83, 95% confidence interval (CI)... (More)
Background: The aim was to identify maternal risk factors in women giving birth to girls with Turner syndrome (TS) and to describe the characteristics of newborns with TS. Methods: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register. Between 1973 and 2005, 494 children with TS were born. Maternal age, parity, height, smoking habits and neonatal characteristics; mode of delivery, gestational age, size at birth and Apgar score, were compared with women in the general population who gave birth to girls during the same period. Results: More women with advanced maternal age (40+) delivered girls with TS, 3.2% when compared with 1.8% in the general population [OR 1.83, 95% confidence interval (CI) 1.09-3.08, after adjustment for year of birth]. Maternal height was inversely associated with TS pregnancies (P = 0.005). Late preterm birth occurred in newborns with TS in 10.5% when compared with 4.8% in the general population (OR 2.23; 95% CI: 1.67-2.97, after adjustment for year of birth and maternal age). Newborns with TS had birthweight less than -2SD in 17.8% and birth length less than -2SD in 21.0% when compared with 3.5 and 3.4%, in the general population (OR 6.55; 95% CI: 5.12-8.38 and OR 8.69; 95% CI: 6.89-10.97, after adjustment for year of birth and maternal age). Conclusion: Advanced maternal age and short stature were risk factors for giving birth to a girl with TS. More TS girls were born late preterm and were smaller for gestational age than non-TS girls in the general population. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pregnancy, Turner syndrome, karyotype, maternal characteristics, neonatal
in
Human Reproduction
volume
25
issue
6
pages
1553 - 1560
publisher
Oxford University Press
external identifiers
  • wos:000277988200027
  • scopus:77952832727
ISSN
0268-1161
DOI
10.1093/humrep/deq060
language
English
LU publication?
yes
id
3fa975b0-5470-4b52-ac86-4d9f6d033f2c (old id 1616785)
date added to LUP
2010-06-22 13:31:43
date last changed
2018-05-29 09:42:23
@article{3fa975b0-5470-4b52-ac86-4d9f6d033f2c,
  abstract     = {Background: The aim was to identify maternal risk factors in women giving birth to girls with Turner syndrome (TS) and to describe the characteristics of newborns with TS. Methods: The Swedish Genetic Turner Register was cross-linked with the Swedish Medical Birth Register. Between 1973 and 2005, 494 children with TS were born. Maternal age, parity, height, smoking habits and neonatal characteristics; mode of delivery, gestational age, size at birth and Apgar score, were compared with women in the general population who gave birth to girls during the same period. Results: More women with advanced maternal age (40+) delivered girls with TS, 3.2% when compared with 1.8% in the general population [OR 1.83, 95% confidence interval (CI) 1.09-3.08, after adjustment for year of birth]. Maternal height was inversely associated with TS pregnancies (P = 0.005). Late preterm birth occurred in newborns with TS in 10.5% when compared with 4.8% in the general population (OR 2.23; 95% CI: 1.67-2.97, after adjustment for year of birth and maternal age). Newborns with TS had birthweight less than -2SD in 17.8% and birth length less than -2SD in 21.0% when compared with 3.5 and 3.4%, in the general population (OR 6.55; 95% CI: 5.12-8.38 and OR 8.69; 95% CI: 6.89-10.97, after adjustment for year of birth and maternal age). Conclusion: Advanced maternal age and short stature were risk factors for giving birth to a girl with TS. More TS girls were born late preterm and were smaller for gestational age than non-TS girls in the general population.},
  author       = {Hagman, A. and Wennerholm, U. -B. and Källén, Karin and Barrenas, M. -L. and Landin-Wilhelmsen, K. and Hanson, C. and Bryman, I.},
  issn         = {0268-1161},
  keyword      = {pregnancy,Turner syndrome,karyotype,maternal characteristics,neonatal},
  language     = {eng},
  number       = {6},
  pages        = {1553--1560},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {Women who gave birth to girls with Turner syndrome: maternal and neonatal characteristics},
  url          = {http://dx.doi.org/10.1093/humrep/deq060},
  volume       = {25},
  year         = {2010},
}