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MHC class I variation associates with parasite resistance and longevity in tropical pythons

Madsen, Thomas LU and Ujvari, Beata LU (2006) In Journal of evolutionary biology 19(6). p.1973-1978
Abstract
Using restriction fragment length polymorphism (RFLP) we identified 26 unique major histocompatibility complex (MHC) genotypes in 104 water pythons. We observed a significant independent association between reduced blood parasite load (Hepatozoon sp.) and python body length/age, presence of a specific RFLP fragment (C-fragment) and the overall number of fragments. The parasite has a negative impact on several python life-history traits such as growth, nutritional status and longevity. Thus, the C-fragment could be considered a 'good gene' (a fitness-enhancing genetic element). However, while the number of fragments affected parasite load, the association between level of parasitaemia and fragment number was not linear, and, hence, minimum... (More)
Using restriction fragment length polymorphism (RFLP) we identified 26 unique major histocompatibility complex (MHC) genotypes in 104 water pythons. We observed a significant independent association between reduced blood parasite load (Hepatozoon sp.) and python body length/age, presence of a specific RFLP fragment (C-fragment) and the overall number of fragments. The parasite has a negative impact on several python life-history traits such as growth, nutritional status and longevity. Thus, the C-fragment could be considered a 'good gene' (a fitness-enhancing genetic element). However, while the number of fragments affected parasite load, the association between level of parasitaemia and fragment number was not linear, and, hence, minimum parasite infection level was achieved at an intermediate number of fragments. Intermediate MHC fragment numbers were also observed among the largest/oldest pythons, suggesting that both a specific fragment and intermediate levels of MHC polymorphism enhanced python longevity. Thus, our results suggest python MHC is subject to both frequency-dependent and balancing selection. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of evolutionary biology
volume
19
issue
6
pages
1973 - 1978
publisher
John Wiley and Sons
external identifiers
  • wos:000241243100025
  • scopus:33750009813
ISSN
1420-9101
DOI
10.1111/j.1420-9101.2006.01158.x
language
English
LU publication?
yes
id
123b15b1-2a01-453d-b1a7-0af676b892aa (old id 162805)
date added to LUP
2016-04-01 12:29:59
date last changed
2021-09-22 02:13:29
@article{123b15b1-2a01-453d-b1a7-0af676b892aa,
  abstract     = {Using restriction fragment length polymorphism (RFLP) we identified 26 unique major histocompatibility complex (MHC) genotypes in 104 water pythons. We observed a significant independent association between reduced blood parasite load (Hepatozoon sp.) and python body length/age, presence of a specific RFLP fragment (C-fragment) and the overall number of fragments. The parasite has a negative impact on several python life-history traits such as growth, nutritional status and longevity. Thus, the C-fragment could be considered a 'good gene' (a fitness-enhancing genetic element). However, while the number of fragments affected parasite load, the association between level of parasitaemia and fragment number was not linear, and, hence, minimum parasite infection level was achieved at an intermediate number of fragments. Intermediate MHC fragment numbers were also observed among the largest/oldest pythons, suggesting that both a specific fragment and intermediate levels of MHC polymorphism enhanced python longevity. Thus, our results suggest python MHC is subject to both frequency-dependent and balancing selection.},
  author       = {Madsen, Thomas and Ujvari, Beata},
  issn         = {1420-9101},
  language     = {eng},
  number       = {6},
  pages        = {1973--1978},
  publisher    = {John Wiley and Sons},
  series       = {Journal of evolutionary biology},
  title        = {MHC class I variation associates with parasite resistance and longevity in tropical pythons},
  url          = {http://dx.doi.org/10.1111/j.1420-9101.2006.01158.x},
  doi          = {10.1111/j.1420-9101.2006.01158.x},
  volume       = {19},
  year         = {2006},
}