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Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population-based cohort study in Sweden

Shu, Xiaochen LU ; Ji, Jianguang LU ; Li, Xinjun LU ; Sundquist, Jan LU and Hemminki, Kari LU (2010) In Diabetic Medicine 27(7). p.791-797
Abstract
P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Registry. Standardized incidence ratios (SIRs) for subsequent cancers were calculated among patients with T1DM compared with those without T1DM. Results Two hundred and fifty-eight cases were ascertained with subsequent cancers during the follow-up duration from 1964 to 2006, with an increased overall SIR of 1.17 (95% CI 1.04-1.33) among 24 052... (More)
P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Registry. Standardized incidence ratios (SIRs) for subsequent cancers were calculated among patients with T1DM compared with those without T1DM. Results Two hundred and fifty-eight cases were ascertained with subsequent cancers during the follow-up duration from 1964 to 2006, with an increased overall SIR of 1.17 (95% CI 1.04-1.33) among 24 052 T1DM patients identified at baseline. Significant excess was noted for gastric and skin (squamous cell carcinoma) cancers and for leukaemia. Increased risk of acute lymphatic leukaemia accounted for most of the variation of leukaemia risk (SIR = 5.31, 95% CI 3.32-8.05). Cancer risk varied with sex, age at first hospitalization and numbers of hospitalizations. The risk was higher in women compared with men and in those hospitalized for T1DM at age over 10 years compared with the younger patients. Higher risks were also found among those with more hospital visits. Conclusion By quantifying the variations of overall and site-specific cancer risks after T1DM, the current study provides novel associations between T1DM and subsequent cancers, the mechanisms of which remain to be established. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
national registry, age at first hospitalization, cancer risk, diabetes mellitus, Type 1
in
Diabetic Medicine
volume
27
issue
7
pages
791 - 797
publisher
Wiley-Blackwell
external identifiers
  • wos:000279440600011
  • scopus:77954249988
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2010.03011.x
language
English
LU publication?
yes
id
723bf9d5-05a8-4ec8-893b-82458f1d23ab (old id 1629256)
date added to LUP
2010-07-22 10:13:57
date last changed
2018-05-29 11:08:18
@article{723bf9d5-05a8-4ec8-893b-82458f1d23ab,
  abstract     = {P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Registry. Standardized incidence ratios (SIRs) for subsequent cancers were calculated among patients with T1DM compared with those without T1DM. Results Two hundred and fifty-eight cases were ascertained with subsequent cancers during the follow-up duration from 1964 to 2006, with an increased overall SIR of 1.17 (95% CI 1.04-1.33) among 24 052 T1DM patients identified at baseline. Significant excess was noted for gastric and skin (squamous cell carcinoma) cancers and for leukaemia. Increased risk of acute lymphatic leukaemia accounted for most of the variation of leukaemia risk (SIR = 5.31, 95% CI 3.32-8.05). Cancer risk varied with sex, age at first hospitalization and numbers of hospitalizations. The risk was higher in women compared with men and in those hospitalized for T1DM at age over 10 years compared with the younger patients. Higher risks were also found among those with more hospital visits. Conclusion By quantifying the variations of overall and site-specific cancer risks after T1DM, the current study provides novel associations between T1DM and subsequent cancers, the mechanisms of which remain to be established.},
  author       = {Shu, Xiaochen and Ji, Jianguang and Li, Xinjun and Sundquist, Jan and Hemminki, Kari},
  issn         = {1464-5491},
  keyword      = {national registry,age at first hospitalization,cancer risk,diabetes mellitus,Type 1},
  language     = {eng},
  number       = {7},
  pages        = {791--797},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population-based cohort study in Sweden},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2010.03011.x},
  volume       = {27},
  year         = {2010},
}