Risk of Cancer Following Hospitalization for Type 2 Diabetes
(2010) In The Oncologist 15(6). p.548-555- Abstract
- Objectives. Cancer and type 2 diabetes (T2D) are two common diseases that may share risk factors. We aimed at determining subsequent cancer risks in patients hospitalized for T2D in Sweden. Methods. T2D patients were obtained from the nationwide Hospital Discharge Register; cancers were recorded from the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancer following last hospitalization for T2D. The comparison group was the general Swedish population. Results. The number of hospitalized T2D patients from 1964 to 2007 was 125,126, of whom 26,641 had an affected family member. Altogether 24 cancers showed an elevated risk when follow-up was started after the last hospitalization. The highest SIRs were for... (More)
- Objectives. Cancer and type 2 diabetes (T2D) are two common diseases that may share risk factors. We aimed at determining subsequent cancer risks in patients hospitalized for T2D in Sweden. Methods. T2D patients were obtained from the nationwide Hospital Discharge Register; cancers were recorded from the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancer following last hospitalization for T2D. The comparison group was the general Swedish population. Results. The number of hospitalized T2D patients from 1964 to 2007 was 125,126, of whom 26,641 had an affected family member. Altogether 24 cancers showed an elevated risk when follow-up was started after the last hospitalization. The highest SIRs were for pancreatic (6.08) and liver (4.25) cancers. The incidences of these cancers were even elevated when follow-up was started 5 years after the last hospitalization for T2D, with primary liver cancer showing the highest SIR of 4.66. Also increased were the incidences of upper aerodigestive tract, esophageal, colon, rectal, pancreatic, lung, cervical, endometrial, ovarian, and kidney cancers. Prostate cancer showed a lower risk. Familial T2D patients showed no exceptional elevated cancer risks but their prostate cancer and melanoma risks were lower. Conclusions. This study, covering approximately one half of Swedish T2D patients, showed an elevated risk for several cancers after hospitalization for T2D, probably indicating the profound metabolic disturbances of the underlying disease. The highest risks were found for liver and pancreatic cancers. No excess cancer risks were observed in familial diabetics. The lower risk for prostate cancer remains intriguing. The Oncologist 2010;15:548-555 (Less)
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https://lup.lub.lu.se/record/1629956
- author
- Hemminki, Kari LU ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Liver cancer, Risk factors, Diabetes, Cancer, Prostate cancer
- in
- The Oncologist
- volume
- 15
- issue
- 6
- pages
- 548 - 555
- publisher
- AlphaMed Press
- external identifiers
-
- wos:000279113300003
- scopus:77954986682
- pmid:20479278
- ISSN
- 1083-7159
- DOI
- 10.1634/theoncologist.2009-0300
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Psychiatry/Primary Care/Public Health (013240500), Family medicine, psychiatric epidemiology and migration (013240037), Family Medicine (013241010), Family medicine, cardiovascular epidemiology and lifestyle (013240038)
- id
- 870e4a54-7a45-4838-a4be-82430b33e33b (old id 1629956)
- date added to LUP
- 2016-04-01 13:44:19
- date last changed
- 2024-02-25 03:47:57
@article{870e4a54-7a45-4838-a4be-82430b33e33b,
abstract = {{Objectives. Cancer and type 2 diabetes (T2D) are two common diseases that may share risk factors. We aimed at determining subsequent cancer risks in patients hospitalized for T2D in Sweden. Methods. T2D patients were obtained from the nationwide Hospital Discharge Register; cancers were recorded from the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancer following last hospitalization for T2D. The comparison group was the general Swedish population. Results. The number of hospitalized T2D patients from 1964 to 2007 was 125,126, of whom 26,641 had an affected family member. Altogether 24 cancers showed an elevated risk when follow-up was started after the last hospitalization. The highest SIRs were for pancreatic (6.08) and liver (4.25) cancers. The incidences of these cancers were even elevated when follow-up was started 5 years after the last hospitalization for T2D, with primary liver cancer showing the highest SIR of 4.66. Also increased were the incidences of upper aerodigestive tract, esophageal, colon, rectal, pancreatic, lung, cervical, endometrial, ovarian, and kidney cancers. Prostate cancer showed a lower risk. Familial T2D patients showed no exceptional elevated cancer risks but their prostate cancer and melanoma risks were lower. Conclusions. This study, covering approximately one half of Swedish T2D patients, showed an elevated risk for several cancers after hospitalization for T2D, probably indicating the profound metabolic disturbances of the underlying disease. The highest risks were found for liver and pancreatic cancers. No excess cancer risks were observed in familial diabetics. The lower risk for prostate cancer remains intriguing. The Oncologist 2010;15:548-555}},
author = {{Hemminki, Kari and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina}},
issn = {{1083-7159}},
keywords = {{Liver cancer; Risk factors; Diabetes; Cancer; Prostate cancer}},
language = {{eng}},
number = {{6}},
pages = {{548--555}},
publisher = {{AlphaMed Press}},
series = {{The Oncologist}},
title = {{Risk of Cancer Following Hospitalization for Type 2 Diabetes}},
url = {{http://dx.doi.org/10.1634/theoncologist.2009-0300}},
doi = {{10.1634/theoncologist.2009-0300}},
volume = {{15}},
year = {{2010}},
}