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Second cancers after testicular cancer diagnosed after 1980 in Sweden

Hemminki, Kari LU ; Liu, H. and Sundquist, Jan LU (2010) In Annals of Oncology 21(7). p.1546-1551
Abstract
Patients and methods: We conducted a study among 5533 survivors of testicular cancer on the basis of Swedish Family-Cancer Database for which the cancer data were retrieved from the nationwide Cancer Registry. Standardized incidence ratios (SIRs) of second cancer were calculated by comparing with the rates of the first cancers. The follow-up was started in 1980 and carried on through 2006. Results: A total of 370 second cancers (6.7% of all patients) were recorded, more in seminoma than in nonseminoma patients. Second testicular cancer showed an SIR of 29 after seminoma and an SIR of 13 after nonseminoma. A total of 10 discordant sites were increased after seminoma compared with seven sites after nonseminoma. Gastrointestinal tract cancers... (More)
Patients and methods: We conducted a study among 5533 survivors of testicular cancer on the basis of Swedish Family-Cancer Database for which the cancer data were retrieved from the nationwide Cancer Registry. Standardized incidence ratios (SIRs) of second cancer were calculated by comparing with the rates of the first cancers. The follow-up was started in 1980 and carried on through 2006. Results: A total of 370 second cancers (6.7% of all patients) were recorded, more in seminoma than in nonseminoma patients. Second testicular cancer showed an SIR of 29 after seminoma and an SIR of 13 after nonseminoma. A total of 10 discordant sites were increased after seminoma compared with seven sites after nonseminoma. Gastrointestinal tract cancers occurred mainly after seminoma and bladder cancers (SIR 8.6 when diagnosis before age 30) occurred after nonseminoma. Conclusions: Of the selective affected second tumors, it will be important to confirm the association of bladder cancer with nonseminoma treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
seminoma, radiotherapy, chemotherapy, multiple cancers, teratoma
in
Annals of Oncology
volume
21
issue
7
pages
1546 - 1551
publisher
Oxford University Press
external identifiers
  • wos:000279185200023
  • scopus:77951971054
ISSN
1569-8041
DOI
10.1093/annonc/mdp562
language
English
LU publication?
yes
id
f1f12304-a5e0-4cf9-bc2f-495672f2942f (old id 1630242)
date added to LUP
2010-07-22 14:35:46
date last changed
2018-05-29 11:18:59
@article{f1f12304-a5e0-4cf9-bc2f-495672f2942f,
  abstract     = {Patients and methods: We conducted a study among 5533 survivors of testicular cancer on the basis of Swedish Family-Cancer Database for which the cancer data were retrieved from the nationwide Cancer Registry. Standardized incidence ratios (SIRs) of second cancer were calculated by comparing with the rates of the first cancers. The follow-up was started in 1980 and carried on through 2006. Results: A total of 370 second cancers (6.7% of all patients) were recorded, more in seminoma than in nonseminoma patients. Second testicular cancer showed an SIR of 29 after seminoma and an SIR of 13 after nonseminoma. A total of 10 discordant sites were increased after seminoma compared with seven sites after nonseminoma. Gastrointestinal tract cancers occurred mainly after seminoma and bladder cancers (SIR 8.6 when diagnosis before age 30) occurred after nonseminoma. Conclusions: Of the selective affected second tumors, it will be important to confirm the association of bladder cancer with nonseminoma treatment.},
  author       = {Hemminki, Kari and Liu, H. and Sundquist, Jan},
  issn         = {1569-8041},
  keyword      = {seminoma,radiotherapy,chemotherapy,multiple cancers,teratoma},
  language     = {eng},
  number       = {7},
  pages        = {1546--1551},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Second cancers after testicular cancer diagnosed after 1980 in Sweden},
  url          = {http://dx.doi.org/10.1093/annonc/mdp562},
  volume       = {21},
  year         = {2010},
}