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Antioxidant Effects of Secondary Metabolites from Geranium psilostemon

Sohretoglu, Didem ; Sabuncuoglu, Suna Atasayar ; Sakar, M. Koray ; Ozgunes, Hilal and Sterner, Olov LU (2010) In Natural Product Communications 5(6). p.899-902
Abstract
An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR)... (More)
An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT). (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pentagalloyl glucose, trigalloyl glucose, SOD, CAT, antioxidant, Geranium, Geraniaceae
in
Natural Product Communications
volume
5
issue
6
pages
899 - 902
publisher
Natural Products Inc
external identifiers
  • wos:000278891800016
  • scopus:77954107722
ISSN
1934-578X
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
fa43a726-c056-4db1-bfa0-88512c96b440 (old id 1630339)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20614819
date added to LUP
2016-04-01 10:28:11
date last changed
2022-04-27 22:25:16
@article{fa43a726-c056-4db1-bfa0-88512c96b440,
  abstract     = {{An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT).}},
  author       = {{Sohretoglu, Didem and Sabuncuoglu, Suna Atasayar and Sakar, M. Koray and Ozgunes, Hilal and Sterner, Olov}},
  issn         = {{1934-578X}},
  keywords     = {{pentagalloyl glucose; trigalloyl glucose; SOD; CAT; antioxidant; Geranium; Geraniaceae}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{899--902}},
  publisher    = {{Natural Products Inc}},
  series       = {{Natural Product Communications}},
  title        = {{Antioxidant Effects of Secondary Metabolites from Geranium psilostemon}},
  url          = {{http://www.ncbi.nlm.nih.gov/pubmed/20614819}},
  volume       = {{5}},
  year         = {{2010}},
}