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Antioxidant Effects of Secondary Metabolites from Geranium psilostemon

Sohretoglu, Didem; Sabuncuoglu, Suna Atasayar; Sakar, M. Koray; Ozgunes, Hilal and Sterner, Olov LU (2010) In Natural Product Communications 5(6). p.899-902
Abstract
An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR)... (More)
An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT). (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pentagalloyl glucose, trigalloyl glucose, SOD, CAT, antioxidant, Geranium, Geraniaceae
in
Natural Product Communications
volume
5
issue
6
pages
899 - 902
publisher
Natural Products Inc
external identifiers
  • wos:000278891800016
  • scopus:77954107722
ISSN
1934-578X
language
English
LU publication?
yes
id
fa43a726-c056-4db1-bfa0-88512c96b440 (old id 1630339)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20614819
date added to LUP
2010-07-23 14:28:50
date last changed
2018-05-29 10:57:36
@article{fa43a726-c056-4db1-bfa0-88512c96b440,
  abstract     = {An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT).},
  author       = {Sohretoglu, Didem and Sabuncuoglu, Suna Atasayar and Sakar, M. Koray and Ozgunes, Hilal and Sterner, Olov},
  issn         = {1934-578X},
  keyword      = {pentagalloyl glucose,trigalloyl glucose,SOD,CAT,antioxidant,Geranium,Geraniaceae},
  language     = {eng},
  number       = {6},
  pages        = {899--902},
  publisher    = {Natural Products Inc},
  series       = {Natural Product Communications},
  title        = {Antioxidant Effects of Secondary Metabolites from Geranium psilostemon},
  volume       = {5},
  year         = {2010},
}